TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement

Rheumatology International

Volumn 30, Issue 5, 2010, Pages 667-670

  Soylu, Alper ^a,b   Kızıldağ, Sefa ^a   Kavukçu, Salih ^a   Cingöz, Sultan ^a   Türkmen, Mehmet ^a   Demir, Belde Kasap ^a   Sakızlı, Meral ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Glomerulonephritis; Henoch Schonlein purpura; Toll like receptors

Indexed keywords

ARGININE; ASPARTIC ACID; CYCLOPHOSPHAMIDE; GLUTAMINE; GLYCINE; ISOLEUCINE; STEROID; THREONINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ADOLESCENT; ADULT; ANAPHYLACTOID PURPURA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE SEQUENCE; HUMAN; INCIDENCE; MALE; NEPHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; SCHOOL CHILD; SEQUENCE ANALYSIS;

EID: 77951023389     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-009-1052-y     Document Type: Article

References (15)

1. Anders HJ, Banas B, Detlef S (2004) Signaling danger: Toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15:854-867
2. Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-14
3. Schroder NWJ, Schumann RR (2005) Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 5:156-164
4. Cook DN, Pisetsky DS, Schwartz DA (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5:975-979
5. Berdeli A, Celik HA, Ozyurek R, Dogrusoz B, Aydin HH (2005) TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. J Mol Med 83:535-541
6. Montes AH, Asensi V, Alvarez V, Valle E, Ocaña MG, Meana A et al (2006) The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis. Clin Exp Immunol 143:404-413
7. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M et al (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187-191
8. Coppo R, Amore A (2004) Henoch-Schönlein purpura. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 851-863
9. Ozdofan H, Arisoy N, Kasapcapur O, Sever L, Caliskan S, Tuzuner N et al (1997) Vasculitis in familial Mediterranean fever. J Rheumatol 24:323-327
10. Ozen S, Berdeli A, Türel B, Kutlay S, Yalcinkaya F, Arici M et al (2006) Arg753Gln TLR-2 polymorphism in familial Mediterranean fever: linking the environment to the phenotype in a monogenic inXammatory disease. J Rheumatol 33:2498-2500
11. Schroder NW, Hermann C, Hamann L, Gobel UB, Hartung T, Schumann RR (2003) High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-speciWc PCR. J Mol Med 81:368-372
12. Lorenz E, Frees KL, Schwartz DA (2001) Determination of the TLR4 genotype using allele-speciWc PCR. Biotechniques 31:22-24
13. Emingil G, Berdeli A, Baylas H, Saygan BH, Gürkan A, Köse T et al (2007) Toll-like receptor 2 and 4 gene polymorphisms in generalized aggressive periodontitis. J Periodontol 78:1968-1977
14. Lorenz E, Mira JP, Cornish KI, Arbour NC, Schwartz DA (2000) A novel polymorphism in the TLR-2 gene and its potential association with staphylococcal infection. Infect Immun 68:6398-6401
15. Snelgrove T, Lim S, Greenwood C et al (2007) Association of tolllike receptor 4 variants and ankylosing spondylitis: a case-control study. J Rheumatol 34:368-370