High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity

Nutrition and Metabolism

Volumn 7, Issue , 2010, Pages

  Van Den Berg, Sjord A A ^a   Guigas, Bruno ^a   Bijland, Silvia ^a   Ouwens, Margriet ^a   Voshol, Peter J ^a   Frants, Rune R ^a   Havekes, Louis M ^a,b   Romijn, Johannes A ^a   Van Dijk, Ko Willems ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LARD; PALM OIL; PROTEIN KINASE B; STEARIC ACID; TRISTEARIN;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY MASS; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY METABOLISM; ENZYME PHOSPHORYLATION; FAT INTAKE; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; SKELETAL MUSCLE; WESTERN BLOTTING;

MUS;

EID: 77950972184     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-7-24     Document Type: Article

References (30)

1. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. R Buettner KG Parhofer M Woenckhaus CE Wrede LA Kunz-Schughart J Scholmerich LC Bollheimer, J Mol Endocrinol 2006 36 485 501 10.1677/jme.1.01909 16720718 (Pubitemid 43904942)
2. Differential effects of fatty acids and exercise on body weight regulation and metabolism in female Wistar rats. KL Jen A Buison M Pellizzon F Ordiz Jr AL Santa J Brown, Exp Biol Med (Maywood) 2003 228 843 849 12876304 (Pubitemid 37169270)
3. A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes. JJ Wilkes A Bonen RC Bell, Am J Physiol 1998 275 679 E686 9755088
4. Specific fatty acid intake and the risk of pancreatic cancer in Canada. A Nkondjock D Krewski KC Johnson P Ghadirian, Br J Cancer 2005 92 971 977 10.1038/sj.bjc.6602380 15685231 (Pubitemid 40462648)
5. Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. J Leyton PJ Drury MA Crawford, Br J Nutr 1987 57 383 393 10.1079/BJN19870046 3109464 (Pubitemid 17081575)
6. Differential oxidation of individual dietary fatty acids in humans. JP DeLany MM Windhauser CM Champagne GA Bray, Am J Clin Nutr 2000 72 905 911 11010930
7. Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylglycerol synthesis and beta-oxidation in cultured rat hepatocytes. T Pai YY Yeh, Lipids 1996 31 159 164 10.1007/BF02522615 8835403 (Pubitemid 26066084)
8. TLR4 links innate immunity and fatty acid-induced insulin resistance. H Shi MV Kokoeva K Inouye I Tzameli H Yin JS Flier, J Clin Invest 2006 116 3015 3025 10.1172/JCI28898 17053832 (Pubitemid 44684486)
9. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. PP Hommelberg J Plat RC Langen AM Schols RP Mensink, Am J Physiol Endocrinol Metab 2009 296 114 E120 10.1152/ajpendo.00436.2007 18957619
10. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. D Cai M Yuan DF Frantz PA Melendez L Hansen J Lee SE Shoelson, Nat Med 2005 11 183 190 10.1038/nm1166 15685173 (Pubitemid 40321354)
11. Table of nonprotein respiratory quotient: an update. F Peronnet D Massicotte, Can J Sport Sci 1991 16 23 29 1645211
12. Leptin deficiency per se dictates body composition and insulin action in ob/ob mice. AM van den Hoek B Teusink PJ Voshol LM Havekes JA Romijn H Pijl, J Neuroendocrinol 2008 20 120 127 18081560 (Pubitemid 350239156)
13. Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production. MA den Boer PJ Voshol F Kuipers JA Romijn LM Havekes, Am J Physiol Endocrinol Metab 2006 291 1360 E1364 10.1152/ajpendo.00188.2006 16849628 (Pubitemid 44904045)
14. Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice. I Duivenvoorden B Teusink PC Rensen JA Romijn LM Havekes PJ Voshol, Diabetes 2005 54 664 671 10.2337/diabetes.54.3.664 15734841 (Pubitemid 40322068)
15. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. JR Goudriaan VE Dahlmans B Teusink DM Ouwens M Febbraio JA Maassen JA Romijn LM Havekes PJ Voshol, J Lipid Res 2003 44 2270 2277 10.1194/jlr.M300143-JLR200 12923231 (Pubitemid 38082485)
16. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. PJ Voshol MC Jong VE Dahlmans D Kratky S Levak-Frank R Zechner JA Romijn LM Havekes, Diabetes 2001 50 2585 2590 10.2337/diabetes.50.11.2585 11679438 (Pubitemid 33642778)
17. Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. EB Nascimento M Fodor GC van der Zon IM Jazet AE Meinders PJ Voshol R Vlasblom B Baan J Eckel JA Maassen, et al. Diabetes 2006 55 3221 3228 10.2337/db05-1390 17130464 (Pubitemid 44923577)
18. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. E Korsheninnikova GC van der Zon PJ Voshol GM Janssen LM Havekes A Grefhorst F Kuipers DJ Reijngoud JA Romijn DM Ouwens, et al. Diabetologia 2006 49 3049 3057 10.1007/s00125-006-0439-5 17006666 (Pubitemid 44730309)
19. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. T Matsuzaka H Shimano N Yahagi T Kato A Atsumi T Yamamoto N Inoue M Ishikawa S Okada N Ishigaki, et al. Nat Med 2007 13 1193 1202 10.1038/nm1662 17906635 (Pubitemid 47530641)
20. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. JA Chavez SA Summers, Arch Biochem Biophys 2003 419 101 109 10.1016/j.abb.2003.08.020 14592453
21. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. A Schaeffler P Gross R Buettner C Bollheimer C Buechler M Neumeier A Kopp J Schoelmerich W Falk, Immunology 2009 126 233 245 10.1111/j.1365-2567. 2008.02892.x 18624726
22. TLR4 links innate immunity and fatty acid-induced insulin resistance. H Shi MV Kokoeva K Inouye I Tzameli H Yin JS Flier, J Clin Invest 2006 116 3015 3025 10.1172/JCI28898 17053832 (Pubitemid 44684486)
23. Nutrient sensing and inflammation in metabolic diseases. GS Hotamisligil E Erbay, Nat Rev Immunol 2008 8 923 934 10.1038/nri2449 19029988
24. Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylglycerol synthesis and beta-oxidation in cultured rat hepatocytes. T Pai YY Yeh, Lipids 1996 31 159 164 10.1007/BF02522615 8835403 (Pubitemid 26066084)
25. Stearic acid modifies very low density lipoprotein lipid composition and particle size differently from shorter-chain saturated fatty acids in cultured rat hepatocytes. T Pai YY Yeh, Lipids 1997 32 143 149 10.1007/s11745-997-0018-z 9075203 (Pubitemid 27093185)
26. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. S Neschen I Moore W Regittnig CL Yu Y Wang M Pypaert KF Petersen GI Shulman, Am J Physiol Endocrinol Metab 2002 282 395 E401 11788372
27. Lipid accumulation in non-adipose tissue and lipotoxicity. NA van Herpen VB Schrauwen-Hinderling, Physiol Behav 2008 94 231 241 10.1016/j.physbeh.2007. 11.049 18222498
28. Role of cholesterol and lipid organization in disease. FR Maxfield I Tabas, Nature 2005 438 612 621 10.1038/nature04399 16319881 (Pubitemid 41740565)
29. Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes. SS Funari F Barcelo PV Escriba, J Lipid Res 2003 44 567 575 10.1194/jlr.M200356-JLR200 12562874 (Pubitemid 37279706)
30. The influence of fatty acids on model cholesterol/phospholipid membranes. K Hac-Wydro P Wydro, Chem Phys Lipids 2007 150 66 81 10.1016/j.chemphyslip. 2007.06.213 17651712 (Pubitemid 47538550)