Metabolism of 17α-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes

Drug Metabolism and Disposition

Volumn 38, Issue 5, 2010, Pages 723-727

  Shringi, Sharma ^a   Ellis, Ewa C S ^d   Dorko, Kenneth ^d   Zhang, Shimin ^a   Mattison, Donald R ^b   Caritis, Steve N ^c   Venkataramanan, Raman ^a,d   Strom, Stephen C ^d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A7; DRUG METABOLITE; HYDROXYPROGESTERONE CAPROATE; 17-ALPHA-HYDROXY-PROGESTERONE CAPROATE; ANTIESTROGEN; CYP3A4 PROTEIN, HUMAN; CYP3A7 PROTEIN, HUMAN; PROGESTERONE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ADULT; ARTICLE; CELL ISOLATION; DRUG CLEARANCE; DRUG METABOLISM; FEMALE; FETUS; FETUS LIVER; GESTATIONAL AGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RISK PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER CELL; MASS SPECTROMETRY; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK REDUCTION; ANIMAL; BIOCATALYSIS; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; INSECT; KINETICS; METABOLISM; MICROSOME; PREGNANCY; PREMATURITY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOCATALYSIS; CYTOCHROME P-450 CYP3A; ESTRADIOL ANTAGONISTS; FEMALE; FETUS; HEPATOCYTES; HUMANS; HYDROXYPROGESTERONES; INSECTS; KINETICS; MICROSOMES; PREGNANCY; PREMATURE BIRTH; TRANSFECTION;

EID: 77950957597     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029918     Document Type: Article

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