Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice

Virology

Volumn 401, Issue 1, 2010, Pages 1-5

  Zhu, Huachen ^a,b   Wang, Jia ^a,b   Wang, Pui ^a,b   Song, Wenjun ^a,b   Zheng, Zuoyi ^a   Chen, Rirong ^a   Guo, Kunyuan ^a   Zhang, Taixing ^a   Peiris, Joseph S M ^b   Chen, Honglin ^a,b   Guan, Yi ^a,b  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Influenza virus; Pathogenicity; PB2 627 residue; Temperature sensitivity; Virulence

Indexed keywords

GLUTAMIC ACID; LYSINE; POLYMERASE BASIC PROTEIN 2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL GROWTH; CELL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; INFLUENZA A (H1N1); INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; MOUSE; NONHUMAN; PANDEMIC; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; TEMPERATURE; VIRAL GENETICS; VIROGENESIS; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DISEASE OUTBREAKS; DOGS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; LYSINE; MICE; MICE, INBRED BALB C; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

MUS; ORTHOMYXOVIRIDAE;

EID: 77950949967     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.02.024     Document Type: Article

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