-
1
-
-
77950943253
-
-
note
-
2NHCONHR.
-
-
-
-
2
-
-
77950954691
-
-
Knieps, S.; Englert, H. C.; Gerlach, U.; Goegelein, H.; Heitsch, H. 'Piperidinesulfonylureas and Thioureas, Their Preparation, Their Use and Pharmaceutical Compositions Comprising Them' WO 2006/063722 A1.
-
Piperidinesulfonylureas and Thioureas, Their Preparation, Their Use and Pharmaceutical Compositions Comprising Them' WO 2006/063722
-
-
Knieps, S.1
Englert, H.C.2
Gerlach, U.3
Goegelein, H.4
Heitsch, H.5
-
3
-
-
0037430430
-
-
10.1016/S0960-894X(03)00028-3
-
Casini A., Winum J.-Y., Montero J.-L., Scozzafava A., and Supuran C.T. Bioorg. Med. Chem. Lett. 13 (2003) 837-840 10.1016/S0960-894X(03)00028-3
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 837-840
-
-
Casini, A.1
Winum, J.-Y.2
Montero, J.-L.3
Scozzafava, A.4
Supuran, C.T.5
-
5
-
-
23944522336
-
-
10.1016/j.bmcl.2005.06.084
-
Sparey T., Beher D., Best J., Biba M., Castro J.L., Clarke E., Hannam J., Harrison T., Lewis H., Madin A., Shearman M., Sohal B., Tsou N., Welch C., and Wrigley J. Bioorg. Med. Chem. Lett. 15 (2005) 4212-4216 10.1016/j.bmcl.2005.06.084
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 4212-4216
-
-
Sparey, T.1
Beher, D.2
Best, J.3
Biba, M.4
Castro, J.L.5
Clarke, E.6
Hannam, J.7
Harrison, T.8
Lewis, H.9
Madin, A.10
Shearman, M.11
Sohal, B.12
Tsou, N.13
Welch, C.14
Wrigley, J.15
-
6
-
-
42949106147
-
-
10.1016/j.bmcl.2008.04.004
-
Benltifa M., Garcia Moreno M.I., Ortiz Mellet C., Garcia Fernandez J.M., and Wadouachi A. Bioorg. Med. Chem. Lett. 18 (2008) 2805 10.1016/j.bmcl.2008.04.004
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 2805
-
-
Benltifa, M.1
Garcia Moreno, M.I.2
Ortiz Mellet, C.3
Garcia Fernandez, J.M.4
Wadouachi, A.5
-
7
-
-
77950943887
-
-
Bender, J. A.; Ding, M.; Gentles, R. G.; Hewawasam, P. 'Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors', WO2009/067108 A1.
-
Bender, J. A.; Ding, M.; Gentles, R. G.; Hewawasam, P. 'Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors', WO2009/067108 A1.
-
-
-
-
8
-
-
39749089270
-
-
10.1021/jm701164t
-
Muraglia E., Kinzel O., Gardelli C., Crescenzi B., Donghi M., Ferrara M., Nizi E., Orvieto F., Pescatore G., Laufer R., Gonzalez-Paz O., Di Marco A., Fiore F., Monteagudo E., Fonsi M., Felock P.J., Rowley M., and Summa V. J. Med. Chem. 51 (2008) 861 10.1021/jm701164t
-
(2008)
J. Med. Chem.
, vol.51
, pp. 861
-
-
Muraglia, E.1
Kinzel, O.2
Gardelli, C.3
Crescenzi, B.4
Donghi, M.5
Ferrara, M.6
Nizi, E.7
Orvieto, F.8
Pescatore, G.9
Laufer, R.10
Gonzalez-Paz, O.11
Di Marco, A.12
Fiore, F.13
Monteagudo, E.14
Fonsi, M.15
Felock, P.J.16
Rowley, M.17
Summa, V.18
-
9
-
-
0033533880
-
-
10.1021/jm991054q
-
Hulten J., Andersson H.O., Schaal W., Danielson H.U., Classon B., Kvarnstrom I., Karlen A., Unge T., Samulesson B., and Hallberg A. J. Med. Chem. 42 (1999) 4054-4061 10.1021/jm991054q
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4054-4061
-
-
Hulten, J.1
Andersson, H.O.2
Schaal, W.3
Danielson, H.U.4
Classon, B.5
Kvarnstrom, I.6
Karlen, A.7
Unge, T.8
Samulesson, B.9
Hallberg, A.10
-
10
-
-
61849122972
-
-
10.1016/j.bmcl.2009.02.075
-
Manku S., Allan M., Nguyen N., Ajamian A., Rodrigue J., Therrien E., Wang J., Guo T., Rahil J., Petschner A.J., Nicolescu A., Lefebvre S., Li Z., Fournel M., Besterman J.M., Deziel R., and Wahhab A. Bioorg. Med. Chem. Lett. 19 (2009) 1866-1870 10.1016/j.bmcl.2009.02.075
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 1866-1870
-
-
Manku, S.1
Allan, M.2
Nguyen, N.3
Ajamian, A.4
Rodrigue, J.5
Therrien, E.6
Wang, J.7
Guo, T.8
Rahil, J.9
Petschner, A.J.10
Nicolescu, A.11
Lefebvre, S.12
Li, Z.13
Fournel, M.14
Besterman, J.M.15
Deziel, R.16
Wahhab, A.17
-
11
-
-
0033517091
-
-
10.1016/S0960-894X(99)00377-7
-
Groutas W.C., Schechter N.M., He S., Yu H., Huan P., and Tu J. Bioorg. Med. Chem. Lett. 9 (1999) 2199-2204 10.1016/S0960-894X(99)00377-7
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 2199-2204
-
-
Groutas, W.C.1
Schechter, N.M.2
He, S.3
Yu, H.4
Huan, P.5
Tu, J.6
-
13
-
-
34948846564
-
-
10.1021/jm070435y
-
Parrish C.A., et al. J. Med. Chem. 50 (2007) 4939 10.1021/jm070435y
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4939
-
-
Parrish, C.A.1
-
15
-
-
65749097887
-
-
10.1016/j.bmcl.2009.04.006
-
Patel S.D., Habeski W.M., Cheng A.C., de la Cruz E., Loh C., and Kablaoui N.M. Bioorg. Med. Chem. Lett. 19 (2009) 3339 10.1016/j.bmcl.2009.04.006
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 3339
-
-
Patel, S.D.1
Habeski, W.M.2
Cheng, A.C.3
de la Cruz, E.4
Loh, C.5
Kablaoui, N.M.6
-
16
-
-
0041731604
-
-
10.1021/jm030025j
-
Lee K., Park C.W., Jung W.-H., Park H.D., Lee S.H., Chung K.H., Park S.K., Kwon O.H., Kang M., Park D.-H., Lee S.K., Kim E.E., Yoon S.K., and Kim A. J. Med. Chem. 46 (2003) 3612-3622 10.1021/jm030025j
-
(2003)
J. Med. Chem.
, vol.46
, pp. 3612-3622
-
-
Lee, K.1
Park, C.W.2
Jung, W.-H.3
Park, H.D.4
Lee, S.H.5
Chung, K.H.6
Park, S.K.7
Kwon, O.H.8
Kang, M.9
Park, D.-H.10
Lee, S.K.11
Kim, E.E.12
Yoon, S.K.13
Kim, A.14
-
17
-
-
34447318072
-
-
10.1016/j.bmcl.2007.06.007
-
Manfredi M.C., Bi Y., Nirschl A.A., Sutton J.C., Seethala R., Golla R., Beehler B.C., Sleph P.G., Grover G.J., Ostrowski J., and Hamann L.G. Bioorg. Med. Chem. Lett. 17 (2007) 4487 10.1016/j.bmcl.2007.06.007
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4487
-
-
Manfredi, M.C.1
Bi, Y.2
Nirschl, A.A.3
Sutton, J.C.4
Seethala, R.5
Golla, R.6
Beehler, B.C.7
Sleph, P.G.8
Grover, G.J.9
Ostrowski, J.10
Hamann, L.G.11
-
18
-
-
2442462015
-
-
10.1016/j.bmcl.2004.03.089
-
Dow R.L., Paight E.S., Schneider S.R., Hadcock J.R., Hargrove D.M., Martin K.A., Maurer T.S., Mardone N.A., Tess D.A., and DaSilva-Jardine P. Bioorg. Med. Chem. Lett. 14 (2004) 3235 10.1016/j.bmcl.2004.03.089
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3235
-
-
Dow, R.L.1
Paight, E.S.2
Schneider, S.R.3
Hadcock, J.R.4
Hargrove, D.M.5
Martin, K.A.6
Maurer, T.S.7
Mardone, N.A.8
Tess, D.A.9
DaSilva-Jardine, P.10
-
21
-
-
72249089530
-
-
doi:10.1021%2Fjm801432r
-
Parker M.H., Smith-Swintosky V.L., McComsey D.F., Huang Y., Brenneman D., Klein B., Malatynska E., White H.S., Milewski M., Herb M., Finley M.F.A., Liu Y., Lubin M.L., Qin N., Iannucci R., Leclercq L., Cuyckens F., Reitz A.B., and Maryanoff B.E. J. Med. Chem. 52 (2009) 7528-7536 doi:10.1021%2Fjm801432r
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7528-7536
-
-
Parker, M.H.1
Smith-Swintosky, V.L.2
McComsey, D.F.3
Huang, Y.4
Brenneman, D.5
Klein, B.6
Malatynska, E.7
White, H.S.8
Milewski, M.9
Herb, M.10
Finley, M.F.A.11
Liu, Y.12
Lubin, M.L.13
Qin, N.14
Iannucci, R.15
Leclercq, L.16
Cuyckens, F.17
Reitz, A.B.18
Maryanoff, B.E.19
-
23
-
-
70449642441
-
-
10.1016/j.ejmech.2009.08.003
-
Cano C., Paez J.A., Goya P., Serrano A., Pavon J., Rodriguez de Fonseca F., Suardiaz M., and Martin M.I. Eur. J. Med. Chem. (2009) 4889 10.1016/j.ejmech.2009.08.003
-
(2009)
Eur. J. Med. Chem.
, pp. 4889
-
-
Cano, C.1
Paez, J.A.2
Goya, P.3
Serrano, A.4
Pavon, J.5
Rodriguez de Fonseca, F.6
Suardiaz, M.7
Martin, M.I.8
-
24
-
-
0035850282
-
-
10.1021/ol0161312
-
Winum J.-Y., Toupet L., Barragan V., Dewynter G., and Montero J.-L. Org. Lett. 3 (2001) 2241 10.1021/ol0161312
-
(2001)
Org. Lett.
, vol.3
, pp. 2241
-
-
Winum, J.-Y.1
Toupet, L.2
Barragan, V.3
Dewynter, G.4
Montero, J.-L.5
-
25
-
-
0033403666
-
-
doi:10.1002/(SICI)1522-2675(19991215)82:12<2432::AID-HLCA2432>3.0.CO;2-H
-
Ducry L., Reinelt S., Seiler P., Diederich F., Bolin D.R., Campbell R.M., and Olson G.L. Helv. Chim. Acta 82 (1999) 2432 doi:10.1002/(SICI)1522-2675(19991215)82:12<2432::AID-HLCA2432>3.0.CO;2-H
-
(1999)
Helv. Chim. Acta
, vol.82
, pp. 2432
-
-
Ducry, L.1
Reinelt, S.2
Seiler, P.3
Diederich, F.4
Bolin, D.R.5
Campbell, R.M.6
Olson, G.L.7
-
27
-
-
77950932393
-
-
Preparation of various sulfamoyl chlorides have been previously reported in following patent publication. Guo, C, Dong, L, Hou, X, Vanderpool, D. L, Villafranca, J. E. PCT Int. Appl. WO 01/40185 A1, 2001
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Preparation of various sulfamoyl chlorides have been previously reported in following patent publication. Guo, C.; Dong, L.; Hou, X.; Vanderpool, D. L.; Villafranca, J. E. PCT Int. Appl. WO 01/40185 A1, 2001.
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77950949571
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note
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2 in deuterated DMSO) consistent with unlabeled product.
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29
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77950949798
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note
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15N-labeled product.
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30
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77950946757
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note
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Nucleophilic addition to either ortho or para position of the pyridinium ring can lead to the same terminal sulfamide side product (21). Ortho addition is shown as an example in the proposed mechanism.
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31
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77950958056
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Synthetic procedure and analytical data of all compounds listed herein have been previously reported in following patent publication. Guo, C, Dong, L, Hou, X, Vanderpool, D. L, Villafranca, J. E. PCT Int. Appl. WO 01/40185 A1, 2001
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Synthetic procedure and analytical data of all compounds listed herein have been previously reported in following patent publication. Guo, C.; Dong, L.; Hou, X.; Vanderpool, D. L.; Villafranca, J. E. PCT Int. Appl. WO 01/40185 A1, 2001.
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