Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 3, 2004, Pages 589-593

  Zhong, Jiaying ^a   Gan, Xiangdong ^a   Alliston, Kevin R ^a   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LEUKOCYTE ELASTASE; SERINE PROTEINASE; SULFANILAMIDE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; EVALUATION; SYNTHESIS;

EID: 0345869922     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.059     Document Type: Article

References (18)

1. Leung D., Abbenante G., Fairlie D.P. J. Med. Chem. 43:2000;305.
2. Maly D.J., Huang L., Ellman J.A. ChemBiochem. 3:2002;16.
3. Zhong, J.; Groutas, W. C. Curr. Top. Med. Chem. In press.
4. Groutas W.C., Epp J.B., Kuang R., Ruan S., Chong L.S., Venkataraman R., Tu J., He S., Yu Q., Fu, Li Y.H., Truong T.M., Vu N.T. Arch. Biochem. Biophys. 385:2001;161.
5. Groutas W.C., He S., Kuang R., Ruan S., Tu J., Chan H.-K. Bioorg. Med. Chem. 9:2002;1543.
6. Kuang R., Epp J.B., Ruan S., Chong L.S., Venkataraman R., Tu J., He S., Truong T.M., Groutas W.C. Bioorg. Med. Chem. 8:2000;1005.
7. Kuang R., Epp J.B., Ruan S., Yu H., Huang P., He S., Tu J., Schechter N.M., Turbov J., Froelich C.J., Groutas W.C. J. Am. Chem. Soc. 121:1999;8128.
8. Groutas W.C., Kuang R., Venkataraman R., Epp J.B., Ruan S., Prakash O. Biochemistry. 36:1997;4739.
9. Wei L., Gan X., Zhong J., Alliston K., Groutas W.C. Bioorg. Med. Chem. 11:2003;5149.
10. Regainia Z., Abdaoui M., Auf N.-E., Dewynter G., Montero J.-L. Tetrahedron. 56:2000;381.
11. Dixon M. Biochem. J. 55:1953;170.
12. Ohbayashi H. Expert Opin. Investig. Drugs. 11:2002;965.
13. Zeiher B.G., Matsuoka S., Kawabata K., Repine J.E. Crit. Care Med. 30:2002;S281.
14. Shamanian P., Pocock B.J.Z., Schwartz J.D., Monea S., Chuang N., Whiting D., Marcus S.G., Galloway A.C., Mignatti P. Surgery. 126:2000;142.
15. Fockens J.A., Ries C., Look M.P., Gippner-Steppert C., Klijn J.G., Jochum M. Cancer Res. 63:2003;337.
16. Metz W.A., Peet N.P. Exp. Opin. Ther. Pat. 9:1999;851.
17. Anderson G.P., Shinagawa K. Curr. Opin. Anti-inflamm. Immunom. Invest. Drugs. 1:1999;29.
18. Schechter I., Berger A. J. Biol. Chem. 12:1962;2940.