Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2851-2854

  Sandanayaka, Vincent ^a   Mamat, Bjorn ^b   Bhagat, Nikhil ^a   Bedell, Louis ^a   Halldorsdottir, Gudrun ^b   Sigthorsdottir, Heida ^b   Andrésson, Thorkell ^b   Kiselyov, Alex ^a   Gurney, Mark ^a,b   Singh, Jasbir ^a  

^a DeCODE Chemistry & Biostructures   (United States)

^b DECODE GENETICS   (Iceland)

Author keywords

Human LTA4H Inhibitors; LTA4 hydrolase inhibitors; Piperidine and piperazine derivatives; Structure based design

Indexed keywords

HYDROLASE INHIBITOR; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE A4 HYDROLASE INHIBITOR; MOLECULAR SCAFFOLD; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; PIPERAZINES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950923265     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.047     Document Type: Article

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