Identification of activated Tnk1 kinase in Hodgkin's lymphoma

Leukemia

Volumn 24, Issue 4, 2010, Pages 861-865

  Gu, T L ^a   Cherry, J ^a   Tucker, M ^a   Wu, J ^a   Reeves, C ^a   Polakiewicz, R D ^a  

^a CELL SIGNALING TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; STAT5 PROTEIN; TNK1 KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LETTER; LIQUID CHROMATOGRAPHY; LYMPHOMA CELL LINE; MALIGNANT TRANSFORMATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

EID: 77950919666     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.293     Document Type: Letter

References (8)

1. Schmitz R, Stanelle J, Hansmann ML, Kuppers R. Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma. Annu Rev Pathol 2009; 4: 151-174.
2. Diehl V, Kirchner HH, Schaadt M, Fonatsch C, Stein H, Gerdes J et al. Hodgkin's disease: establishment and characterization of four in vitro cell lies. J Cancer Res Clin Oncol 1981; 101: 111-124.
3. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ et al. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol 2005; 23: 94-101.
4. Hoehn GT, Stokland T, Amin S, Ramirez M, Hawkins AL, Griffin CA et al. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin\/CD38\stem/progenitor cells. Oncogene 1996; 12: 903-913.
5. Hoare S, Hoare K, Reinhard MK, Lee YJ, Oh SP, May Jr WS. Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res 2008; 68: 8723-8732.
6. Azoitei N, Brey A, Busch T, Fulda S, Adler G, Seufferlein T. Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apop-tosis by blocking NF-kappaB activation. Oncogene 2007; 26: 6536-6545.
7. Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG et al. A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 2007; 110: 323-333.
8. Lierman E, Van Miegroet H, Beullens E, Cools J. Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen. Haematologica 2009; 94: 1440-1444.