The role of alkoxy group on the A ring of isoflavones in the inhibition of interleukin-5

Archives of Pharmacal Research

Volumn 30, Issue 8, 2007, Pages 950-954

  Yang, Hyun Mo ^a   Shin, Hye Rim ^a   Bang, Seong Cheol ^a   Lee, Ki Cheol ^a   Hoang, Le Tuan Anh ^a   Lee, In Jeong ^b   Kim, Youngsoo ^b   Jung, Sang Hun ^a  

^a Chungnam National University   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Inhibitor; Interleukin 5; Isoflavones

Indexed keywords

ALCOHOL DERIVATIVE; ALKOXY RADICAL; BENZOPYRAN DERIVATIVE; INTERLEUKIN 5; ISOFLAVONE DERIVATIVE; SOPHORICOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; EOSINOPHILIA; HYPERSENSITIVITY; IC 50; IMMUNOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ALCOHOLS; BENZOPYRANS; CHROMATOGRAPHY, THIN LAYER; EOSINOPHILIA; HYPERSENSITIVITY; INHIBITORY CONCENTRATION 50; INTERLEUKIN-5; ISOFLAVONES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548756783     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02993962     Document Type: Article

References (13)

1. Allakhverdi, Z., Allam, M., and Renzi, P. M., Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. Am. J. Respir. Crit. Care Med., 165, 1015-1021 (2002).
2. Devos, R., Guisez, Y., Plaetinck, G., Cornelis, S., Traverier, J., Van der Heyden, J., Florey, C. H., and Scheffler, J. E., Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5. Eur. J. Biochem., 225, 635-640 (1994).
3. Djukanovic, R., Asthma: A disease of inflammation and repair. J. Allergy Clin. Immunol., 105, 522-526 (2000).
4. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I., and Young, I. G., Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med., 183, 195-201 (1996).
5. Hamelmann, E. and Gelfand, E. W., Role of IL-5 in the development of allergen-induced airway hyperresponsiveness. Int. Arch. Allergy Immunol., 120, 8-16 (1999).
6. Hogan, S. P., Matthaei, K. I., Young, J. M., Koskinen, A., Young, I. G., and Foster, P. S., A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol., 161, 1501-1509 (1998).
7. Jung, S. H., Cho, S. H., Dang, T. H., Lee, J. H., Ju, J. H., Kim, M. K., Lee, S. H., Ryu, J. C., and Kim, Y., Structural requirement of isoflavonones for the inhibitory activity of interleukin-5. Eur. J. Med. Chem., 38, 537 (2003).
8. Kraneveld, A. D., Folkerts, G., Van Oosterhout, A. J., and Nijkamp, F. P., Airway hyperresponsiveness: first eosinophils and then neuropeptides. Int. J. Immunopharmacol., 19, 517-527 (1997).
9. Min, B., Oh, S. H., Lee, H.-K., Takatsu, K., Chang, I.-M., Min, K. R., and Kim, Y., Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica. Planta Med., 65, 408-412 (1999).
10. Perrin, D. D., Armarego, W. L. F., and Perrin, D. R., Purification of laboratory chemicals, 2nd edition. Pergamon Press, Oxford, England, (1982).
11. Yang, H. M. Shin H. R., Cho, S. H., Song, G. Y., Lee, I. J., Kim, M. K., Lee, S. H., Ryu, J. C., Kim, Y., and Jung, S. H., The role of hydrophobic group on A ring of chalcones in the inhibition of interleukin-5, Arch. Pharm. Res., 29, 969-976 (2006)
12. Yang, H. M. Shin H. R., Cho, S. H., Song, G. Y., Lee, I. J., Kim, M. K., Lee, S. H., Ryu, J. C., Kim, Y., and Jung, S. H., Bioorg. Med. Chem., (2007)
13. Yun, J., Lee, C.-K., Chang, I.-M., Takatsu, K., Hirano, T., Min, K. R., Lee, M. K., and Kim, Y., Differential inhibitory effects of sophoricoside analogs on bioactivity of several cytokines. Life Sci., 67, 2855-2863 (2000).