Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-α

Carcinogenesis

Volumn 31, Issue 3, 2010, Pages 521-531

  Boccardo, Enrique ^a   Baldi, Carina Victoria Manzini ^a,b,d   Carvalho, Alex Fiorini ^a,e   Rabachini, Tatiana ^a   Torres, César ^c   Barreta, Luiz André ^c,f   Brentani, Helena ^c   Villa, Luisa Lina ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c A C CAMARGO CANCER CENTER   (Brazil)

^d JOHNSON AND JOHNSON   (United States)

^e Fundacxão Antônio Prudente ^*  (Brazil)

^f Secretaria de Meio Ambiente do Estado de São Paulo ^*  (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; HAPTOCORRIN; HIGH MOBILITY GROUP B2 PROTEIN; INTERFERON INDUCED PROTEIN 44; PROTEIN E7; PROTEIN FUS; RETINOBLASTOMA PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MESSENGER RNA; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSTASIS; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UTERINE CERVIX CARCINOMA IN SITU; VIRUS CARCINOGENESIS; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE S PHASE; CELL DIVISION; COMPARATIVE STUDY; CULTURE TECHNIQUE; DNA REPLICATION; DRUG EFFECT; DRUG RESISTANCE; GENE; GENE EXPRESSION; GENETICS; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; VIROLOGY; VIRUS CELL TRANSFORMATION;

CELL CULTURE TECHNIQUES; CELL DIVISION; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; DNA DAMAGE; DNA REPLICATION; DRUG RESISTANCE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; GENES, CDC; HUMAN PAPILLOMAVIRUS 16; HUMANS; KERATINOCYTES; MALE; MOLECULAR SEQUENCE DATA; PAPILLOMAVIRUS E7 PROTEINS; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; S PHASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77950895158     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp333     Document Type: Article

References (50)

1. Schlecht, N.F. et al. (2001) Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA, 286, 3106-3114.
2. Stanley, M. (2006) Immune responses to human papillomavirus. Vaccine, 24 (suppl. 1), S16-S22.
3. Kyo, S. et al. (1994) Regulation of early gene expression of human papillomavirus type 16 by inflammatory cytokines. Virology, 200, 130-139.
4. Rösl, F. et al. (1994) Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids. J. Virol., 68, 2142-2150.
5. Soto, U. et al. (1999) Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-alpha mediated repression of viral transcription and modification of the AP-1 transcription complex. Oncogene, 18, 3187-3198.
6. Villa, L.L. et al. (1992) Differential effect of tumor necrosis factor on proliferation of primary human keratinocytes and cell lines containing human papillomavirus types 16 and 18. Mol. Carcinog., 6, 5-9.
7. Vieira, K.B. et al. (1996) Tumor necrosis factor alpha interferes with the cell cycle of normal and papillomavirus-immortalized human keratinocytes. Cancer Res., 56, 2452-2457.
8. Termini, L. et al. (2008) Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment. BMC Med. Genomics, 1, 29.
9. Basile, J.R. et al. (2001) The cytokines tumor necrosis factor-alpha (TNFalpha) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein. J. Biol. Chem., 276, 22522-22528
10. Boccardo, E. et al. (2004) HPV-18 confers resistance to TNF-alpha in organotypic cultures of human keratinocytes. Virology, 328, 233-243.
11. Chow, L.T. et al. (1997) In vitro experimental systems for HPV: epithelial raft cultures for investigations of viral reproduction and pathogenesis and for genetic analyses of viral proteins and regulatory sequences. Clin. Dermatol., 15, 217-227.
12. Helt, A.M. et al. (2001) Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes. J. Virol., 75, 6737-6747.
13. Gomes, L.I. et al. (2003) Comparative analysis of amplified and nonamplified RNA for hybridization in cDNA microarray. Anal. Biochem., 321, 244-251.
14. Brentani, R.R. et al. (2005) Gene expression arrays in cancer research: methods and applications. Crit. Rev. Oncol. Hematol., 54, 95-105.
15. Gene Expression Omnibus-NCBI http://www.ncbi.nlm.nih.gov/geo Under acc numbers GPL1930 and GSE17892 (14 December 2009, date last accessed).
16. Zhang, B. et al. (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res., 33, W741-W748.
17. Saeed, A.I. et al. (2003) TM4: a free, open source system for microarray data management and analysis. Biotechniques, 34, 374-378.
18. Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, e45.
19. McLaughlin-Drubin, M.E. et al. (2009) The human papillomavirus E7 oncoprotein. Virology., 384, 335-344.
20. Banerjee, N.S. et al. (2006) Conditionally activated E7 proteins of high-risk and low-risk human papillomaviruses induce S phase in postmitotic, differentiated human keratinocytes. J. Virol., 80, 6517-6524.
21. Cheng, S. et al. (1995) Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev., 9, 2335-2349.
22. Flores, E.R. et al. (2000) The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J. Virol., 74, 6622-6631.
23. Jones, D.L. et al. (1997) The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev., 11, 2101-2111.
24. Ruesch, M.N. et al. (1997) Initiation of DNA synthesis by human papillo- mavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity. J. Virol., 71, 5570-5578.
25. Sherr, C.J. et al. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev., 13, 1501-1512.
26. Demers, G.W. et al. (1996) Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation. J. Virol., 70, 6862-6869.
27. Thierry, F. et al. (2004) A genomic approach reveals a novel mitotic path- way in papillomavirus carcinogenesis. Cancer Res., 64, 895-903.
28. Garner-Hamrick, P.A. et al. (2004) Global effects of human papillomavirus type 18 E6/E7 in an organotypic keratinocyte culture system. J. Virol., 78, 9041-9050.
29. Nees, M. et al. (2001) Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes. J. Virol., 75, 4283-4296.
30. Wan, F. et al. (2008) Gene expression changes during HPV-mediated car-cinogenesis: a comparison between an in vitro cell model and cervical cancer. Int. J. Cancer, 123, 32-40.
31. Chertov, O. et al. (1996) Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from inter-leukin-8-stimulated neutrophils. J. Biol. Chem., 271, 2935-2940.
32. Dorschner, R.A. et al. (2001) Cutaneous injury induces the release of cath- elicidin anti-microbial peptides active against group A Streptococcus. J. Invest. Dermatol., 117, 91-97.
33. Conner, K. et al. (2002) The antimicrobial peptide LL-37 is expressed by keratinocytes in condyloma acuminatum and verruca vulgaris. J. Am. Acad. Dermatol., 47, 347-350.
34. Valore, E.V. et al. (2002) Antimicrobial components of vaginal fluid. Am. J. Obstet. Gynecol., 187, 561-568.
35. Buck, C.B. et al. (2006) Human alpha-defensins block papillomavirus in- fection. Proc. Natl Acad. Sci. USA, 103, 1516-1521.
36. Chatterjee, M. et al. (2004) Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood, 104, 3712-3721.
37. Yuan, H. et al. (2004) IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Carcinogenesis, 25, 2247-2255.
38. Barnard, P. et al. (1999) The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha. Virology, 259, 305-313.
39. Barnard, P. et al. (2000) The human papillomavirus E7 protein is able to inhibit the antiviral and anti-growth functions of interferon-alpha. Virology, 277, 411-419.
40. Chang, Y.E. et al. (2000) Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J. Virol., 74, 4174-4182.
41. Hallen, L.C. et al. (2007) Antiproliferative activity of the human IFN-alpha- inducible protein IFI44. J. Interferon Cytokine Res., 27, 675-680.
42. Andersson, M.K. et al. (2008) The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell. Biol., 9, 37.
43. Gregory, R.I. et al. (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature, 432, 235-240.
44. Shiohama, A. et al. (2007) Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp. Cell Res., 313, 4196-4207.
45. Law, W.J. et al. (2006) TLS, EWS and TAF15: a model for transcriptional integration of gene expression. Brief Funct. Genomic Proteomic., 5, 8-14.
46. Riggi, N. et al. (2007) Sarcomas: genetics, signaling, and cellular origins. Part 1: the fellowship of TET. J. Pathol., 213, 4-20.
47. Davidson, E.J. et al. (2003) Minichromosome maintenance (Mcm) proteins, cyclin B1 and D1, phosphohistone H3 and in situ DNA replication for functional analysis of vulval intraepithelial neoplasia. Br. J. Cancer, 88, 257-262.
48. Fay, J. et al. (2009) Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer. J. Med. Virol., 81, 897-907.
49. Murphy, N. et al. (2005) p16INK4A, CDC6, and MCM5: predictive bio- markers in cervical preinvasive neoplasia and cervical cancer. J. Clin. Pathol., 58, 525-534.
50. Wentzensen, N. et al. (2007) Biomarkers in cervical cancer screening. Dis. Markers, 23, 315-330.