The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers

Human Psychopharmacology

Volumn 25, Issue 3, 2010, Pages 260-267

  Takahashi, Masahiro ^a   Iwamoto, Kunihiro ^a   Kawamura, Yukiko ^b   Nakamura, Yukako ^a   Ishihara, Ryoko ^a   Uchiyama, Yuji ^c   Ebe, Kazutoshi ^c   Noda, Akiko ^d   Noda, Yukihiro ^b   Yoshida, Keizo ^e   Iidaka, Tetsuya ^a   Ozaki, Norio ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c Rd Management Section   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

^e DENSO CORPORATION   (Japan)

Author keywords

Anxiolytics; Cognitive function; Diazepam; Driving performance; Tandospirone

Indexed keywords

DIAZEPAM; PLACEBO; TANDOSPIRONE; ISOINDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRIVING ABILITY; EXPERIMENTAL TEST; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIMULATOR; CAR DRIVING; COMPARATIVE STUDY; DRUG EFFECTS; PHYSIOLOGY; PSYCHOLOGY; PSYCHOMOTOR PERFORMANCE; REACTION TIME; TIME;

ADULT; AUTOMOBILE DRIVING; COGNITION; CROSS-OVER STUDIES; DIAZEPAM; DOUBLE-BLIND METHOD; HUMANS; ISOINDOLES; MALE; PIPERAZINES; PSYCHOMOTOR PERFORMANCE; PYRIMIDINES; REACTION TIME; TIME FACTORS;

EID: 77950894509     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.1105     Document Type: Article

References (47)

1. Barbee JG. 1993. Memory, benzodiazepines, and anxiety: integration of theoretical and clinical perspectives. J Clin Psychiatry 54 (Suppl): 86-97.
2. Barbee JG, Black FW, Kehoe CE, Todorov AA. 1991. A comparison of the single-dose effects of alprazolam, buspirone, and placebo upon memory function. J Clin Psychopharmacol 11: 351-356.
3. Barbone F, McMahon AD, Davey PG, et al. 1998. Association of road-traffic accidents with benzodiazepine use. Lancet 352: 1331-1336. (Pubitemid 28510912)
4. Boulenger JP, Squillace K, Simon P, Herrou M, Leymarie P, Zarifian E. 1989. Buspirone and diazepam: comparison of subjective, psychomotor and biological effects. Neuropsychobiology 22: 83-89. (Pubitemid 20222994)
5. Bramness JG, Skurtveit S, Morland J. 2002. Clinical impairment of benzodiazepines-relation between benzodiazepine concentrations and impairment in apprehended drivers. Drug Alcohol Depend 68: 131-141. (Pubitemid 35251884)
6. Brookhuis K, de Waard D, Mulder B. 1994. Measuring driving performance by car-following in traffic. Ergonomics 37: 427-434.
7. Callicott JH, Bertolino A, Mattay VS, et al. 2000. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 10: 1078-1092.
8. Callicott JH, Egan MF, Mattay VS, et al. 2003. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry 160: 709-719. (Pubitemid 41079604)
9. Chamberlain SR, Muller U, Deakin JB, et al. 2007. Lack of deleterious effects of buspirone on cognition in healthy male volunteers. J Psychopharmacol 21: 210-215. (Pubitemid 46280474)
10. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. 1988. The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 26: 223-238.
11. Coull JT, Middleton HC, Robbins TW, Sahakian BJ. 1995a. Clonidine and diazepam have differential effects on tests of attention and learning. Psychopharmacology (Berl) 120: 322-332.
12. Coull JT, Middleton HC, Robbins TW, Sahakian BJ. 1995b. Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology (Berl) 120: 311-321.
13. de Visser SJ, van der Post JP, de Waal PP, Cornet F, Cohen AF, van Gerven JM. 2003. Biomarkers for the effects of benzodiazepines in healthy volunteers. Br J Clin Pharmacol 55: 39-50. (Pubitemid 36110838)
14. Dimitriou EC, Dimitriou CE. 1998. Buspirone augmentation of antidepressant therapy. J Clin Psychopharmacol 18: 465-469.
15. Evans SM, Troisi JR, II, Griffiths RR. 1994. Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans. J Pharmacol Exp Ther 271: 683-694. (Pubitemid 24377751)
16. Feighner JP, Merideth CH, Hendrickson GA. 1982. A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder. J Clin Psychiatry 43: 103-108. (Pubitemid 13221556)
17. Hart RP, Colenda CC, Hamer RM. 1991. Effects of buspirone and alprazolam on the cognitive performance of normal elderly subjects. Am J Psychiatry 148: 73-77.
18. Heaton RK. 1981. The Wisconsin Card Sorting Test (Manual). Psychological Assessment Resources: Odessa, FL.
19. Hoddes E, Zarcone V, Smythe H, Phillips R, Dement WC. 1973. Quantification of sleepiness: a new approach. Psychophysiology 10: 431-436.
20. Iwamoto K, Takahashi M, Nakamura Y, et al. 2008. The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: a double-blind crossover trial. Hum Psychopharmacol 23: 399-407.
21. Jacobson AF, Dominguez RA, Goldstein BJ, Steinbook RM. 1985. Comparison of buspirone and diazepam in generalized anxiety disorder. Pharmacotherapy 5: 290-296.
22. Kashima H, Honda T, Kato M, et al. 1987. Neuropsychological investigation on chronic schizophrenia-aspect of its frontal functions. In Takahashi R, Flor-Henry P, Gruzelier J, Niwa S (eds). Cerebral Dynamics, Laterality and Psychopathology. Elsevier: Amsterdam.
23. Kozena L, Frantik E, Horvath M. 1995. Vigilance impairment after a single dose of benzodiazepines. Psychopharmacology (Berl) 119: 39-45.
24. Mohler H, Fritschy JM, Rudolph U. 2002. A new benzodiazepine pharmacology. J Pharmacol Exp Ther 300: 2-8.
25. Moskowitz H, Smiley A. 1982. Effects of chronically administered buspirone and diazepam on driving-related skills performance. J Clin Psychiatry 43: 45-55. (Pubitemid 13221546)
26. Neutel CI. 1995. Risk of traffic accident injury after a prescription for a benzodiazepine. Ann Epidemiol 5: 239-244.
27. Neutel I. 1998. Benzodiazepine-related traffic accidents in young and elderly drivers. Hum Psychopharmacol 13: S115-S123.
28. National Highway Traffic Safety Administration, U.S. Department of Transportation. 2008. Traffic Safety Facts 2007, Washinton, DC.
29. National Police Agency Transportation Authority. 2009. Generation status of traffic accidents during the 20 year of the Heisei era. Tokyo.
30. O'Hanlon JF. 1984. Driving performance under the influence of drugs: rationale for, and application of, a new test. Br J Clin Pharmacol 18 (Suppl 1): 121S-129S.
31. O'Hanlon JF, Haak TW, Blaauw GJ, Riemersma JB. 1982. Diazepam impairs lateral position control in highway driving. Science 217: 79-81.
32. O'Hanlon JF, Vermeeren A, Uiterwijk MM, van Veggel LM, Swijgman HF. 1995. Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies. Neuropsychobiology 31: 81-88.
33. Oster G, Huse DM, Adams SF, Imbimbo J, Russell MW. 1990. Benzodiazepine tranquilizers and the risk of accidental injury. Am J Public Health 80: 1467-1470.
34. Ramaekers JG. 2003. Antidepressants and driver impairment: empirical evidence from a standard on-the-road test. J Clin Psychiatry 64: 20-29.
35. Rapoport MJ, Lanctot KL, Streiner DL, et al. 2009. Benzodiazepine use and driving: a meta-analysis. J Clin Psychiatry 70: 663-673.
36. Ray WA, Fought RL, Decker MD. 1992. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 136: 873-883.
37. Schaffler K, Klausnitzer W. 1989. Placebo-controlled study on acute and subchronic effects of buspirone vs bromazepam utilizing psychomotor and cognitive assessments in healthy volunteers. Pharmacopsychiatry 22: 26-33.
38. Shimizu H, Hirose A, Tatsuno T, Nakamura M, Katsube J. 1987. Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate. Jpn J Pharmacol 45: 493-500.
39. Smiley A, Moskowitz H. 1986. Effects of long-term administration of buspirone and diazepam on driver steering control. Am J Med 80: 22-29.
40. Snyder PJ, Werth J, Giordani B, Caveney AF, Feltner D, Maruff P. 2005. A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam. Hum Psychopharmacol 20: 263-273.
41. Stewart SA. 2005. The effects of benzodiazepines on cognition. J Clin Psychiatry 66 (Suppl 2): 9-13.
42. Suzuki M, Uchiumi M, Murasaki M. 1993. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam. Yakubutsu Seishin Kodo 13: 213-224.
43. Uchiyama Y, Ebe K, Kozato A, Okada T, Sadato N. 2003. The neural substrates of driving at a safe distance: a functional MRI study. Neurosci Lett 352: 199-202. (Pubitemid 38367602)
44. van Laar MW, Volkerts ER, van Willigenburg AP. 1992. Therapeutic effects and effects on actual driving performance of chronically administered buspirone and diazepam in anxious outpatients. J Clin Psychopharmacol 12: 86-95.
45. Verster JC, Veldhuijzen DS, Volkerts ER. 2005. Is it safe to drive a car when treated with anxiolytics? Evidence from on-the-road driving studies during normal traffic. Curr Psychiatry Rev 1: 215-225.
46. Whiting PJ. 2006. GABA-A receptors: a viable target for novel anxiolytics? Curr Opin Pharmacol 6: 24-29.
47. Wieland S, Lucki I. 1990. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test. Psychopharmacology (Berl) 101: 497-504. (Pubitemid 20220042)