Benzodiazepine use and driving: A meta-analysis

Journal of Clinical Psychiatry

Volumn 70, Issue 5, 2009, Pages 663-673

  Rapoport, Mark J ^a,e   Lanctôt, Krista L ^a   Streiner, David L ^b   Bédard, Michel ^c   Vingilis, Evelyn ^d   Murray, Brian ^a   Schaffer, Ayal ^a   Shulman, Kenneth I ^a   Herrmann, Nathan ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b BAYCREST CENTRE FOR GERIATRIC CARE   (Canada)

^c LAKEHEAD UNIVERSITY   (Canada)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE;

ARTICLE; CAR DRIVING; CASE CONTROL STUDY; DRIVING ABILITY; DRUG USE; HUMAN; PRIORITY JOURNAL; SIMULATION; TRAFFIC ACCIDENT;

ACCIDENTS, TRAFFIC; AUTOMOBILE DRIVING; BENZODIAZEPINES; HUMANS; SUBSTANCE-RELATED DISORDERS;

EID: 67049136598     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.08m04325     Document Type: Article

References (56)

1. Vingilis E, MacDonald S. Review: drugs and traffic collisions. Traffic Inj Prev 2002;3(1):1-11 (Pubitemid 34847173)
2. Schwilke EW, Sampaio dos Santos MI, Logan BK. Changing patterns of drug and alcohol use in fatally injured drivers in Washington State. J Forensic Sci 2006;51(5):1191-1198
3. Stahl SM. Essential Psychopharmacology. 2nd ed. New York, NY: Cambridge University Press; 2000
4. Walsh JM, de Gier JJ, Christopherson AS, et al. Drugs and driving. Traffic Inj Prev 2004;5(3):241-253 (Pubitemid 39049928)
5. Bezchlibnyk-Butler KZ, Jeffries JJ. Clinical Handbook of Psychotropic Drugs. Toronto, Canada: Hogrefe & Huber Publishers; 2001
6. Sweetman SC. Martindale: The Complete Drug Reference. 34th ed. Chicago, Ill: Pharmaceutical Press; 2005
7. Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-129
8. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50(4):1088-1101
9. McAlister FA, Straus SE, Guyatt GH, et al. Users' guides to the medical literature, XX: integrating research evidence with the care of the individual patient. Evidence-Based Medicine Working Group. JAMA 2000;283(21):2829-2836
10. Honkanen R, Ertama L, Linnoila M, et al. Role of drugs in traffic accidents. Br Med J 1980;281(6251):1309-1312 (Pubitemid 10029852)
11. Mura P, Kintz P, Ludes B, et al. Comparison of the prevalence of alcohol, cannabis, and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Sci Int 2003;133(1-2):79-85 (Pubitemid 36555422)
12. McGwin G Jr, Sims RV, Pulley L, et al. Relations among chronic medical conditions, medications, and automobile crashes in the elderly: a population- based case-control study. Am J Epidemiol 2000;152(5):424-431 (Pubitemid 30696362)
13. Skegg DC, Richards SM, Doll R. Minor tranquillisers and road accidents. Br Med J 1979;1(6168):917-919 (Pubitemid 9148193)
14. Leveille SG, Buchner DM, Koepsell TD, et al. Psychoactive medications and injurious motor vehicle collisions involving older drivers. Epidemiology 1994;5(6):591-598 (Pubitemid 24336510)
15. Hemmelgarn B, Suissa S, Huang A, et al. Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA 1997;278(1):27-31 (Pubitemid 27274512)
16. Oster G, Russell MW, Huse DM, et al. Accident- and injury-related health-care utilization among benzodiazepine users and nonusers. J Clin Psychiatry 1987;48(12, suppl):17-21 (Pubitemid 18026880)
17. Neutel CI. Risk of traffic accident injury after a prescription for a benzodiazepine. Ann Epidemiol 1995;5(3):239-244
18. Ray WA, Fought RL, Decker MD. Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 1992;136(7):873-883
19. Lagier G. Are benzodiazepines a risk factor for road accidents. Drug Alcohol Depend 1993;33:19-22 (Pubitemid 23219905)
20. Longo MC, Hunter CE, Lokan RJ, et al. The prevalence of alcohol, cannabinoids, benzodiazepines, and stimulants amongst injured drivers and their role in driver culpability, pt 2: the relationship between drug prevalence and drug concentration, and driver culpability. Accid Anal Prev 2000;32(5):623-632
21. Dureman I, Malmgren H, Norrman B. Comparison studies of chlorazepate administered as a divided daily dose and as a single dose at night. Psychopharmacology (Berl) 1978;57(2):123-126 (Pubitemid 8330899)
22. Dureman I, Norrman B. Clinical and experimental comparison of diazepam, chlorazepate and placebo. Psychopharmacologia 1975;40(4):279-284
23. Friedel B, Joo S, Reker K, et al. Testing drivers taking diazepam in the Daimler-Benz Driving Simulator. J Traffic Med 1991;19(1):15-27
24. Linnoila M, Hakkinen S. Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving. Clin Pharmacol Ther 1974;15(4):368-373
25. Mattila M. Acute and subacute effects of diazepam on human performance: comparison of plain tablet and controlled release capsule. Pharmacol Toxicol 1988;63(5):369-374 (Pubitemid 19084056)
26. Mattila MJ, Vanakoski J, Kalska H, et al. Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory. Pharmacol Biochem Behav 1998;59(4):917-923 (Pubitemid 28237904)
27. Partinen M, Hirvonen K, Hublin C, et al. Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia. Sleep Med 2003;4(6):553-561 (Pubitemid 38145658)
28. Staner L, Ertle S, Boeijinga P, et al. Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring. Psychopharmacology (Berl) 2005;181(4):790-798 (Pubitemid 41400765)
29. Volkerts ER, van Laar MW, Van Willigenburg APP, et al. A comparative study of on-the-road and simulated driving performance after nocturnal treatment with lormetazepam 1 mg and oxazepam 50 mg. Hum Psychopharmacol 1992;7:297-309 (Pubitemid 23076873)
30. Harrison C, Subhan Z, Hindmarch I. Residual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving. Drugs Exp Clin Res 1985;11(12):823-829 (Pubitemid 16179818)
31. Hindmarch I, Subhan Z. The effects of midazolam in conjunction with alcohol on sleep, psychomotor performance and car driving ability. Int J Clin Pharmacol Res 1983;3(5):323-329 (Pubitemid 14158802)
32. Moore NC. Medazepam and the driving ability of anxious patients. Psychopharmacology (Berl) 1977;52(1):103-106 (Pubitemid 8072160)
33. O'Hanlon JF. Driving performance under the influence of drugs: rationale for, and application of, a new test. Br J Clin Pharmacol 1984;18(suppl 1):121S-129S (Pubitemid 15184113)
34. O'Hanlon JF, Vermeeren A, Uiterwijk MM, et al. Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardized test: an integration of three studies. Neuropsychobiology 1995;31(2):81-88
35. van Laar MW, Volkerts ER, van Willigenburg AP. Therapeutic effects and effects on actual driving performance of chronically administered buspirone and diazepam in anxious outpatients. J Clin Psychopharmacol 1992;12(2):86-95
36. Verster JC, Volkerts ER, Verbaten MN. Effects of alprazolam on driving ability, memory functioning, and psychomotor performance: a randomized, placebo-controlled study. Neuropsychopharmacology 2002;27(2):260-269 (Pubitemid 34686976)
37. Neutel I. Benzodiazepine-related traffic accidents in young and elderly drivers. Hum Psychopharmacol 1998;13:S115-S123 (Pubitemid 28512916)
38. Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ 2000;162(2):225-233 (Pubitemid 30073249)
39. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis, pt 1: psychotropic drugs. J Am Geriatr Soc 1999;47(1):30-39 (Pubitemid 29044264)
40. Magrini N, Vaccheri A, Parma E, et al. Use of benzodiazepines in the Italian general population: prevalence, pattern of use, and risk factors for use. Eur J Clin Pharmacol 1996;50(1-2):19-25 (Pubitemid 26141503)
41. Mamdani M, Rapoport M, Shulman KI, et al. Mental health-related drug utilization among older adults: prevalence, trends, and costs. Am J Geriatr Psychiatry 2005;13(10):892-900 (Pubitemid 46638678)
42. Glass J, Lanctot KL, Herrmann N, et al. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ 2005;331(7526):1169 (Pubitemid 41689427)
43. Thomas RE. Benzodiazepine use and motor vehicle accidents: systematic review of reported association. Can Fam Physician 1998;44:799-808 (Pubitemid 28248522)
44. Friedel B, Staak M. Benzodiazepines and driving performance. In: Utzelmann HD, Berghaus G, Kroj G, eds. Alcohol, Drugs, and Traffic Safety. Kohn, Germany: Verlag TUV Rheinland GmbH; 1993:539-545
45. Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23(3):260-268 (Pubitemid 36807793)
46. Hobi V, Dubach U, Skreta M, et al. The effect of bromazepam on psychomotor activity and subjective mood. J Int Med Res 1981;9(2):89-97 (Pubitemid 11153963)
47. Sakol MS, Power KG. The effects of long-term benzodiazepine treatment and graded withdrawal on psychometric performance. Psychopharmacology (Berl) 1988;95(1):135-138 (Pubitemid 18111718)
48. Rapoport MJ, Banina MC. Impact of psychotropic medications on simulated driving: a critical review. CNS Drugs 2007;21(6):503-519 (Pubitemid 46849185)
49. Molnar FJ, Patel A, Marshall SC, et al. Clinical utility of office-based cognitive predictors of fitness to drive in persons with dementia: a systematic review. J Am Geriatr Soc 2006;54(12):1809-1824 (Pubitemid 44915823)
50. Verster JC, Veldhuijzen DS, Patat A, et al. Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test. Curr Drug Safety 2006;1(1):63-71
51. McAuley L, Pham B, Tugwell P, et al. Does the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses? Lancet 2000;356(9237):1228-1231
52. Ellen RL, Marshall SC, Palayew M, et al. Systematic review of motor vehicle crash risk in persons with sleep apnea. J Clin Sleep Med 2006;2(2):193-200 (Pubitemid 43893272)
53. Powell NB, Schechtman KB, Riley RW, et al. Sleepy driver near-misses may predict accident risks. Sleep 2007;30(3):331-342 (Pubitemid 46494409)
54. Peden M, Scurfield R, Sleet D, et al., eds. World report on road traffic injury prevention. Geneva, Switzerland: World Health Organization; 2004. Available at: http://whqlibdoc.who.int/publications/2004/9241562609.pdf. Accessibility verified Feb 25, 2009
55. Rxlist. The Top 300 Prescriptions for 2005 by Number of US Prescriptions Dispensed. Available at: http://www.rxlist.com/script/main/art.asp?articlekey= 79509. Accessibility verified Dec 15, 2008
56. McCabe SE. Correlates of nonmedical use of prescription benzodiazepine anxiolytics: results from a national survey of U.S. college students. Drug Alcohol Depend 2005;79(1):53-62 (Pubitemid 41557124)