Rapid development and optimization of cell culture media

BioPharm International

Volumn 21, Issue 1, 2008, Pages 60-68

  Zhang, Min ^a   Lawshé, Avril ^a   Koskie, Kerry ^a   Johnson, Terrell ^a   Caple, Matthew V ^a   Ross, James S ^a  

^a Cell Sciences and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; IMMUNOGLOBULIN G;

ANIMAL CELL; ARTICLE; BIOENGINEERING; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG INDUSTRY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; NONHUMAN; NUTRITIONAL REQUIREMENT; PROTEIN PROCESSING;

EID: 39149124854     PISSN: 1542166X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. McKeehan W, McKeehan K, Ham R. The relationship between defined low-molecular-weight substances and undefined serum-derived factors in the multiplication of untransformed fibroblasts. The Growth Requirements of Vertebrate Cells In Vitro, Chapter 15 (Waymouth C, Ham R, Chapple P eds.), Cambridge Univ Press (New York). 1981:223-243.
2. Cassulis P, Magasic MV, DeBari VA. Ligand affinity chromatographic separation of serum IgG on recombinant protein G-silica Clin Chem. 1991;37:882-886.
3. Montgomery D. Design and analysis of experiments. Fourth Edition. John Wiley and Sons, New York; 1997.
4. Cornell J. How to run mixture experiments for product quality. The ASQC basic references in quality control: statistical techniques (Shapiro S, Mykytka E eds.) Vol. 5. Quality Press, Milwaukee, WI; 1990.
5. Castro P, Hayter PM, Ison AP, Bull AT. Application of statistical design to the optimization of culture medium for recombinant interferon-gamma production by Chinese Hamster Ovary cells. Appl Microbiol Biotechnol. 1992(38):84-90.
6. Moran EB, et al. A systematic approach to the validation of process control parameters for monoclonal antibody production in fed-batch culture of a murine myeloma. Biotechnol Bioeng. 2000(69):242-255.