Prednisolone alone, or in combination with estrogen or dietary calcium deficiency or immobilization, inhibits bone formation but does not induce bone loss in mature rats

Bone

Volumn 21, Issue 4, 1997, Pages 345-351

  Shen, V ^a,b   Birchman, R ^a   Liang, X G ^a   Wu, D D ^a   Lindsay, R ^a,b   Dempster, D W ^a,b  

^a HELEN HAYES HOSPITAL   (United States)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

Dietary calcium deficiency; Glucocorticoid; Immobilization; Osteoporosis; Ovariectomy

Indexed keywords

CALCIUM; ESTROGEN; GLUCOCORTICOID; PREDNISOLONE; PYRIDINOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE ATROPHY; BONE DENSITY; BONE GROWTH; BONE MINERAL; BONE STRENGTH; CALCIUM DEFICIENCY; CALCIUM INTAKE; CANCELLOUS BONE; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN DEFICIENCY; FEMALE; FEMUR; IMMOBILIZATION; MORPHOMETRICS; NONHUMAN; ORAL DRUG ADMINISTRATION; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; RAT; RISK FACTOR; TIBIA; TRABECULAR BONE; URINE LEVEL;

AMINO ACIDS; ANIMALS; BODY WEIGHT; BONE DENSITY; BONE DEVELOPMENT; BONE RESORPTION; CALCIUM, DIETARY; DISEASE MODELS, ANIMAL; ESTROGENS; FEMALE; FEMUR; HUMANS; IMMOBILIZATION; PREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 0030724957     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00153-1     Document Type: Article

References (28)

1. Baylink, D. J. Glucocorticoid-induced osteoporosis. New Engl J Med 309:306-308; 1983.
2. Conaway, H. H., Grigore, D., and Lerner, U. H. Stimulation of neonatal calvarial bone resorption by glucocorticoids, hydrocortisone and dexamethasone. J Bone Miner Res 11:1419-1429; 1996.
3. Dempster, D. W. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 4:137-141; 1989.
4. Dempster, D. W., Moonga, B. S., Stein, L., Horbert, W., and Antakly, T. Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis. J Endocrinol. In press.
5. Dempster, D. W., Stein, L., and Antakly, T. Glucocorticoid receptors in rat osteoclasts mediate cell death by apoptosis. Bone 16 (Suppl. 1 ): 170S (abstract); 1995.
6. Dempster, D. W., Stein, L., Horbert, W., Chowdhury, M., Hamada, C., and Murrills, R. Contrasting effects of glucocorticoids on rat and chick osteoclasts. J Bone Miner Res 5 (Suppl 2):S94; 1990.
7. Goulding, A. and Gold, E. Effects of chronic prednisolone treatment on bone resorption and bone composition in intact and ovariectomized rats and in ovariectomized rats receiving beta-estradiol. Endocrinol 122:482-487; 1988.
8. Gronowicz, G., McCarthy, M. B., and Raisz, L. G. Glucocorticoids stimulate resorption in fetal rat parietal bone in vitro. J Bone Miner Res 5:1223-1230; 1990.
9. Hahn, T. J., Halstead, L. R., and Baran, D. T. Effects of short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol 52:111-115; 1981.
10. 3 modulates glucocorticoid-induced alteration in serum bone gla protein and bone histomorphometry. Endocrinol 120:531-536; 1987.
11. King, C. S., Weir, E. C., Gundberg, C. W., Fox, J., and Insogna, K. Effects of continuous glucocorticoid infusion on bone metabolism in the rat. Calcif Tissue Int 69:184-191; 1996.
12. Li, M., Shen, Y., Halloran, B. P., Baumann, B. D., Miller, K., and Wronski, T. J. Skeletal response to corticosteroid deficiency and excess in growing male rats. Bone 19:81-89; 1996.
13. 3: An effective prophylactic treatment for glucocorticoid osteopenia in rats. Calcif Tissue Int 35:107-110; 1983.
14. 2D. Clin Orthop Relat Res 181:264-268; 1983.
15. Lowe, C., Gray, D. H., and Reid, I. R. Serum blocks the osteolytic effect of cortisol in neonatal mouse calvaria. Calcif Tissue Int 50:189-192; 1992.
16. Lukert, B. P. and Raisz, L. G. Glucocorticoid-induced osteoporosis: Pathogenesis and management. Ann Intern Med 112:352-364; 1990.
17. Meng, X. W., Liang, X. G., Birchman, R., Wu, D. D., Dempster, D. W., Lindsay, R., and Shen, V. Temporal expression of the anabolic action of PTH in cancellous bone of ovariectomized rats. J Bone Miner Res 11:421-429; 1996.
18. Ortoft, G., Bruel, A., Andreassen, T. T., and Oxlund, H. Growth hormone is not able to counteract osteopenia of rat cortical bone induced by glucocorticoid with protracted effect. Bone 17:543-548; 1995.
19. Ortoft, G. and Oxlund, H. Reduced strength of rat cortical bone after glucocorticoid treatment. Calcif Tissue Int 43:376-382; 1988.
20. Raisz, L. G., Trummel, C. L., Wener, J. A., and Simmons, H. Effect of glucocorticoids on bone resorption in tissue culture. Endocrinol 90:961-967; 1972.
21. Reid, I. R. Pathogenesis and treatment of steroid osteoporosis. Clin Endocrinol 30:83-103; 1989.
22. Reid, I. R., Katz, J. M., Ibbertson, H. K., and Gray, D. H. The effects of hydrocortisone, PTH and the bisphosphonate, APD, on bone resorption in neonatal mouse calvaria. Calcif Tissue Int 38:38-43; 1986.
23. Shuto, T., Kukita, T., Hirata, M., and Jimi, E. Dexamethasone stimulate osteoclast-like cell formation by inhibiting granulocyte-macrophage colonystimulating factor production in mouse bone marrow cultures. Endocrinol 134:1121-1126; 1994.
24. Stern, P. H. Inhibition by steroids of PTH induced calcium-45 release from embryonic rat bone in vitro. J Pharmacol Exp Ther 168:211-216; 1969.
25. Storey, E. Bone changes associated with cortisone administration in the rat: Effect of variation in dietary calcium and phosphorus. Br J Exp Pathol 2:207-213; 1960.
26. Tobias, J. and Chambers, T. J. Glucocorticoids impair bone resorptive activity and viability of osteoclasts disaggregated from neonatal rat long bones. Endocrinol 125:1290-1295; 1989.
27. Turner, R. T., Hannon, K. S., Greene, V. S., and Bell, N. H. Prednisone inhibits formation of cortical bone in sham-operated and ovariectomized rats. Calcif Tissue Int 56:311-315; 1995.
28. Udagawa, N., Takahashi, N., Akatsu, T., Sasaki, T., Yamaguchi, A., Kodama, H., Martin, T. J., and Suda, T. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in coculture with mouse spleen cells. Endocrinol 125:1805-1813; 1989.