Synthesis, characterization and antihypertensive activity of pyridazinone derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2283-2290

  Siddiqui, Anees A ^a   Mishra, Ravinesh ^a   Shaharyar, Mohammad ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Aroyl propionic acid; Antihypertensive activity; Non invasive method; Pyridazinone

Indexed keywords

6 (4 ETHYLPHENYL) 2 (MORPHOLIN 4 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 ETHYLPHENYL) 2 (PYRROLIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 ETHYLPHENYL) 2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 (1,2 DIHYDRO 10H PHENOTHIAZIN 10 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 (1H INDOL 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 (MORPHOLIN 4 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 (PIPERAZIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 (PIPERIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHOXYLPHENYL) 2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (1,2 DIHYDRO 10H PHENOTHIAZIN 10 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (1H INDOL 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (2,3 DIHYDRO 1H 1,2,4 TRIAZOL 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (MORPHOLIN 4 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (PIPERAZIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (PIPERIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 (PYRROLIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 (4 METHYLPHENYL) 2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (1,2 DIHYDRO 10H PHENOTHIAZIN 10 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (1,2,4 TRIAZOLIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (1H INDOL 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (MORPHOLIN 4 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (PIPERAZIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (PIPERIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 (PYRROLIDIN 1 YLMETHYL) 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; 6 PHENYL 2 [(4 METHYLPIPERAZIN 1 YL)METHYL] 4,5 DIHYDROPYRIDAZIN 3(2H)ONE; AMINE; HYDRALAZINE; PHENYL 4,5 DIHYDROPYRIDAZIN 3(2H)ONE DERIVATIVE; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; CUFF; DRUG SYNTHESIS; MANNICH REACTION; MEAN ARTERIAL PRESSURE; NON INVASIVE PROCEDURE; NONHUMAN; RAT; TAIL;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; PYRIDAZINES; RATS;

EID: 77950858856     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.003     Document Type: Article

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