-
1
-
-
34247249906
-
Vascular disrupting agents in clinical development
-
Hinnen P and Eskens FA: Vascular disrupting agents in clinical development. Br J Cancer 96: 1159-1165, 2007.
-
(2007)
Br J Cancer.
, vol.96
, pp. 1159-1165
-
-
Hinnen, P.1
Eskens, F.A.2
-
2
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel R and Folkman J: Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2: 727-739, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
3
-
-
60949107352
-
Phase i evaluation of vascular disrupting agent OXi4503
-
Patterson DM, Charnley N, Saleem A, et al: Phase I evaluation of vascular disrupting agent OXi4503. J Clin Oncol 26: 3551, 2008.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 3551
-
-
Patterson, D.M.1
Charnley, N.2
Saleem, A.3
-
4
-
-
33750299899
-
Phase II study of combretastatin A4 phosphate (CA 4P) in patients with advanced anaplastic thyroid carcinoma (ATC)
-
Cooney MM, Savvides P, Agarwala S, et al: Phase II study of combretastatin A4 phosphate (CA 4P) in patients with advanced anaplastic thyroid carcinoma (ATC). J Clin Oncol 24: 5580, 2006.
-
(2006)
J Clin Oncol.
, vol.24
, pp. 5580
-
-
Cooney, M.M.1
Savvides, P.2
Agarwala, S.3
-
5
-
-
40549125995
-
Phase i clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors
-
LoRusso PM, Gadgeel SM, Wozniak A, et al: Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors. Invest New Drugs 26: 159-167, 2008.
-
(2008)
Invest New Drugs
, vol.26
, pp. 159-167
-
-
Lorusso, P.M.1
Gadgeel, S.M.2
Wozniak, A.3
-
6
-
-
44649138596
-
A phase II study of ABT-751 in patients with advanced non-small cell lung cancer
-
Mauer AM, Cohen EE , Ma PC, et al: A phase II study of ABT-751 in patients with advanced non-small cell lung cancer. J Thorac Oncol 3: 631-636, 2008.
-
(2008)
J Thorac Oncol.
, vol.3
, pp. 631-636
-
-
Mauer, A.M.1
Cohen, E.E.2
Ma, P.C.3
-
7
-
-
42249093188
-
Population pharmacokinetic-pharmacodynamic model of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid in cancer patients
-
Li J, Jameson MB, Baguley BC, Pili R and Baker SD: Population pharmacokinetic-pharmacodynamic model of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid in cancer patients. Clin Cancer Res 14: 2102-2110, 2008.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 2102-2110
-
-
Li, J.1
Jameson, M.B.2
Baguley, B.C.3
Pili, R.4
Baker, S.D.5
-
8
-
-
0027537616
-
Differential effects of active isomers, segments and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity
-
Bai R, Roach MC, Jayaram SK, et al: Differential effects of active isomers, segments and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity. Biochem Pharmacol 45: 1503-1515, 1993.
-
(1993)
Biochem Pharmacol
, vol.45
, pp. 1503-1515
-
-
Bai, R.1
Roach, M.C.2
Jayaram, S.K.3
-
9
-
-
0025183762
-
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites
-
Bai RL , Pettit GR and Hamel E: Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J Biol Chem 265: 17141-17149, 1990.
-
(1990)
J Biol Chem.
, vol.265
, pp. 17141-17149
-
-
Bai, R.L.1
Pettit, G.R.2
Hamel, E.3
-
10
-
-
0023584049
-
The isolation and structure of a remarkable murine animal antineoplastic constituent: Dolastatin 10
-
Pettit GR, Kamano Y, Herald CL , et al: The isolation and structure of a remarkable murine animal antineoplastic constituent: dolastatin 10. J Am Chem Soc 109: 6883-6885, 1987.
-
(1987)
J Am Chem Soc.
, vol.109
, pp. 6883-6885
-
-
Pettit, G.R.1
Kamano, Y.2
Herald, C.L.3
-
12
-
-
0032950658
-
Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: Induction of apoptosis and bcl-2 modification
-
Kalemkerian GP, Ou X, Adil MR, et al: Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification. Cancer Chemother Pharmacol 43: 507-515, 1999.
-
(1999)
Cancer Chemother Pharmacol.
, vol.43
, pp. 507-515
-
-
Kalemkerian, G.P.1
Ou, X.2
Adil, M.R.3
-
13
-
-
0031888974
-
Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma
-
Mohammad RM, Pettit GR, Almatchy VP, Wall N, Varterasian M and Al-Katib A: Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma. Anticancer Drugs 9: 149-156, 1998.
-
(1998)
Anticancer Drugs
, vol.9
, pp. 149-156
-
-
Mohammad, R.M.1
Pettit, G.R.2
Almatchy, V.P.3
Wall, N.4
Varterasian, M.5
Al-Katib, A.6
-
14
-
-
0034093431
-
Phase II study of dolastatin-10 in patients with advanced non-small cell lung cancer
-
Krug LM, Miller VA, Kalemkerian GP, et al: Phase II study of dolastatin-10 in patients with advanced non-small cell lung cancer. Ann Oncol 11: 227-228, 2000.
-
(2000)
Ann Oncol.
, vol.11
, pp. 227-228
-
-
Krug, L.M.1
Miller, V.A.2
Kalemkerian, G.P.3
-
15
-
-
0033739893
-
Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma
-
Vaishampayan U, Glode M, Du W, et al: Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma. Clin Cancer Res 6: 4205-4208, 2000.
-
(2000)
Clin Cancer Res.
, vol.6
, pp. 4205-4208
-
-
Vaishampayan, U.1
Glode, M.2
Du, W.3
-
16
-
-
0034851434
-
Dolastatin-10 in metastatic melanoma: A phase II and pharmokinetic trial of the California Cancer Consortium
-
Margolin K, Longmate J, Synold TW, et al: Dolastatin-10 in metastatic melanoma: a phase II and pharmokinetic trial of the California Cancer Consortium. Invest New Drugs 19: 335-340, 2001.
-
(2001)
Invest New Drugs
, vol.19
, pp. 335-340
-
-
Margolin, K.1
Longmate, J.2
Synold, T.W.3
-
17
-
-
0036795186
-
Phase II study of dolastatin-10 as first-line treatment for advanced colorectal cancer
-
Saad ED , Kraut EH, Hoff PM, et al: Phase II study of dolastatin-10 as first-line treatment for advanced colorectal cancer. Am J Clin Oncol 25: 451-453, 2002.
-
(2002)
Am J Clin Oncol.
, vol.25
, pp. 451-453
-
-
Saad, E.D.1
Kraut, E.H.2
Hoff, P.M.3
-
18
-
-
0037384048
-
A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: A Gynecologic Oncology Group Study
-
Hoffman MA, Blessing JA and Lentz SS: A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group Study. Gynecol Oncol 89: 95-98, 2003.
-
(2003)
Gynecol Oncol.
, vol.89
, pp. 95-98
-
-
Hoffman, M.A.1
Blessing, J.A.2
Lentz, S.S.3
-
19
-
-
18844461704
-
Phase II trial of dolastatin-10 in patients with advanced breast cancer
-
Perez EA, Hillman DW, Fishkin PA, et al: Phase II trial of dolastatin-10 in patients with advanced breast cancer. Invest New Drugs 23: 257-261, 2005.
-
(2005)
Invest New Drugs
, vol.23
, pp. 257-261
-
-
Perez, E.A.1
Hillman, D.W.2
Fishkin, P.A.3
-
20
-
-
23844535643
-
Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers
-
Kindler HL, Tothy PK, Wolff R, et al: Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers. Invest New Drugs 23: 489-493, 2005.
-
(2005)
Invest New Drugs
, vol.23
, pp. 489-493
-
-
Kindler, H.L.1
Tothy, P.K.2
Wolff, R.3
-
21
-
-
0028826495
-
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications
-
Pettit GR, Srirangam JK, Barkoczy J, et al: Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications. Anticancer Drug Des 10: 529-544, 1995.
-
(1995)
Anticancer Drug des
, vol.10
, pp. 529-544
-
-
Pettit, G.R.1
Srirangam, J.K.2
Barkoczy, J.3
-
22
-
-
0028842473
-
Synthesis and antitumor activity of novel dolastatin 10 analogs
-
Miyazaki K, Kobayashi M, Natsume T, et al: Synthesis and antitumor activity of novel dolastatin 10 analogs. Chem Pharm Bull 43: 1706-1718, 1995.
-
(1995)
Chem Pharm Bull
, vol.43
, pp. 1706-1718
-
-
Miyazaki, K.1
Kobayashi, M.2
Natsume, T.3
-
23
-
-
0031668094
-
Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides
-
Harrigan GG, Luesch H, Yoshida WY, et al: Symplostatin 1: a dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. J Nat Prod 61: 1075-1077, 1998.
-
(1998)
J Nat Prod.
, vol.61
, pp. 1075-1077
-
-
Harrigan, G.G.1
Luesch, H.2
Yoshida, W.Y.3
-
24
-
-
33846041131
-
A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy
-
Riely GJ, Gadgeel S, Rothman I, et al: A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy. Lung Cancer 55: 181-185, 2007.
-
(2007)
Lung Cancer
, vol.55
, pp. 181-185
-
-
Riely, G.J.1
Gadgeel, S.2
Rothman, I.3
-
25
-
-
0037392709
-
Effects of the antimitotic natural product dolastatin 10 and related peptides on the human malarial parasite Plasmodium falciparum
-
Fennell BJ, Carolan S, Pettit GR and Bell A: Effects of the antimitotic natural product dolastatin 10 and related peptides on the human malarial parasite Plasmodium falciparum. J Antimicrob Chemother 51: 833-841, 2003.
-
(2003)
J Antimicrob Chemother
, vol.51
, pp. 833-841
-
-
Fennell, B.J.1
Carolan, S.2
Pettit, G.R.3
Bell, A.4
-
26
-
-
35148827486
-
Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models
-
Shnyder SD, Cooper PA, Millington NJ, Pettit GR and Bibby MC: Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models. Int J Oncol 31: 353-360, 2007.
-
(2007)
Int J Oncol.
, vol.31
, pp. 353-360
-
-
Shnyder, S.D.1
Cooper, P.A.2
Millington, N.J.3
Pettit, G.R.4
Bibby, M.C.5
-
27
-
-
0842311660
-
Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in a transplantable murine adenocarcinoma model
-
Shnyder SD, Cooper PA, Gyselinck N, Hill BT, Double JA and Bibby MC: Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in a transplantable murine adenocarcinoma model. Anticancer Res 23: 4815-4820, 2003.
-
(2003)
Anticancer Res
, vol.23
, pp. 4815-4820
-
-
Shnyder, S.D.1
Cooper, P.A.2
Gyselinck, N.3
Hill, B.T.4
Double, J.A.5
Bibby, M.C.6
-
28
-
-
0037562506
-
Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model
-
Shnyder SD, Cooper PA, Pettit GR, Lippert JW III and Bibby MC: Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model. Anticancer Res 23: 1619-1623, 2003.
-
(2003)
Anticancer Res.
, vol.23
, pp. 1619-1623
-
-
Shnyder, S.D.1
Cooper, P.A.2
Pettit, G.R.3
Lippert Iii, J.W.4
Bibby, M.C.5
-
29
-
-
16744368637
-
United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR ) Guidelines for the Welfare of Animals in Experimental Neoplasia (2nd edition)
-
Workman P, Twentyman P, Balkwill F, et al: United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR ) Guidelines for the Welfare of Animals in Experimental Neoplasia (2nd edition). Br J Cancer 77: 1-10, 1998.
-
(1998)
Br J Cancer
, vol.77
, pp. 1-10
-
-
Workman, P.1
Twentyman, P.2
Balkwill, F.3
-
30
-
-
0026742089
-
The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours
-
Quinn PK, Bibby MC, Cox JA and Crawford SM: The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours. Br J Cancer 66: 323-330, 1992.
-
(1992)
Br J Cancer
, vol.66
, pp. 323-330
-
-
Quinn, P.K.1
Bibby, M.C.2
Cox, J.A.3
Crawford, S.M.4
-
31
-
-
0023935131
-
Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours
-
Smith KA, Hill SA, Begg AC and Denekamp J: Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours. Br J Cancer 57: 247-253, 1988.
-
(1988)
Br J Cancer
, vol.57
, pp. 247-253
-
-
Smith, K.A.1
Hill, S.A.2
Begg, A.C.3
Denekamp, J.4
-
32
-
-
65549164757
-
Microtubule depolymerizing vascular disrupting agents: Novel therapeutic agents for oncology and other pathologies
-
Kanthou C and Tozer GM: Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies. Int J Exp Pathol 90: 284-294, 2009.
-
(2009)
Int J Exp Pathol.
, vol.90
, pp. 284-294
-
-
Kanthou, C.1
Tozer, G.M.2
-
33
-
-
33748869678
-
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
-
Horsman MR and Siemann DW : Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res 66: 11520-11539, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 11520-11539
-
-
Horsman, M.R.1
Siemann, D.W.2
-
34
-
-
76449086344
-
Combretastatin A-4 phosphate (CA 4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: Final phase II trial results
-
Zweifel M, Jayson G, Reed N, et al: Combretastatin A-4 phosphate (CA 4P) carboplatin and paclitaxel in patients with platinum-resistant ovarian cancer: Final phase II trial results. J Clin Oncol 27: 5502, 2009.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 5502
-
-
Zweifel, M.1
Jayson, G.2
Reed, N.3
-
35
-
-
0344082608
-
Progress in the development and acquisition of anticancer agents from marine sources
-
Amador ML, Jimeno J, Paz-Ares L, Cortes-Funes H and Hidalgo M: Progress in the development and acquisition of anticancer agents from marine sources. Ann Oncol 14: 1607-1615, 2003.
-
(2003)
Ann Oncol.
, vol.14
, pp. 1607-1615
-
-
Amador, M.L.1
Jimeno, J.2
Paz-Ares, L.3
Cortes-Funes, H.4
Hidalgo, M.5
-
36
-
-
57749202046
-
Vascular targeted therapies in oncology
-
Siemann DW and Horsman MR: Vascular targeted therapies in oncology. Cell Tissue Res 335: 241-248, 2009.
-
(2009)
Cell Tissue Res.
, vol.335
, pp. 241-248
-
-
Siemann, D.W.1
Horsman, M.R.2
|