-
1
-
-
0029925375
-
Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
-
Clemente CG, Mihm MC, Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996, 77:1303-10.
-
(1996)
Cancer
, vol.77
, pp. 1303-1310
-
-
Clemente, C.G.1
Mihm, M.C.2
Bufalino, R.3
Zurrida, S.4
Collini, P.5
Cascinelli, N.6
-
2
-
-
0030052833
-
Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response
-
Mihm MC, Clemente CG, Cascinelli N. Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response. Lab Invest 1996, 74:43-7.
-
(1996)
Lab Invest
, vol.74
, pp. 43-47
-
-
Mihm, M.C.1
Clemente, C.G.2
Cascinelli, N.3
-
3
-
-
36549027289
-
Anti-CTLA4 antibody clinical trials in Melanoma
-
Ribas A. Anti-CTLA4 antibody clinical trials in Melanoma. Update Cancer Ther 2007, 2:133-39.
-
(2007)
Update Cancer Ther
, vol.2
, pp. 133-139
-
-
Ribas, A.1
-
4
-
-
34848910544
-
Cytotoxic T-lymphocyte-associated antigen-4
-
Hodi FS. Cytotoxic T-lymphocyte-associated antigen-4. Clin Cancer Res 2007, 13:5238-42.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5238-5242
-
-
Hodi, F.S.1
-
6
-
-
0036301503
-
CTLA-4: new insights into its biological function and use in tumor immunotherapy
-
Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002, 3:611-18.
-
(2002)
Nat Immunol
, vol.3
, pp. 611-618
-
-
Egen, J.G.1
Kuhns, M.S.2
Allison, J.P.3
-
7
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995, 182:459-65.
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
8
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994, 1:405-13.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
Linsley, P.S.4
Freeman, G.J.5
Green, J.M.6
-
9
-
-
0036180686
-
CTLA-4 regulates cell cycle progression during a primary immune response
-
Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 2002, 32:366-73.
-
(2002)
Eur J Immunol
, vol.32
, pp. 366-373
-
-
Greenwald, R.J.1
Oosterwegel, M.A.2
van der Woude, D.3
Kubal, A.4
Mandelbrot, D.A.5
Boussiotis, V.A.6
-
10
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM. Reversal of the TCR stop signal by CTLA-4. Science 2006, 313:1972-5.
-
(2006)
Science
, vol.313
, pp. 1972-1975
-
-
Schneider, H.1
Downey, J.2
Smith, A.3
Zinselmeyer, B.H.4
Rush, C.5
Brewer, J.M.6
-
11
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995, 270:985-8.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
-
12
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3:541-7.
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
13
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996, 271:1734-6.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
14
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999, 190:355-66.
-
(1999)
J Exp Med
, vol.190
, pp. 355-366
-
-
van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
15
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy
-
van Elsas A, Sutmuller RP, Hurwitz AA, Ziskin J, Villasenor J, Medema JP. Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 2001, 194:481-9.
-
(2001)
J Exp Med
, vol.194
, pp. 481-489
-
-
van Elsas, A.1
Sutmuller, R.P.2
Hurwitz, A.A.3
Ziskin, J.4
Villasenor, J.5
Medema, J.P.6
-
16
-
-
20744432041
-
Tumor immunotherapy: preclinical and clinical activity of anti-CTLA4 antibodies
-
Korman A, Yellin M, Keler T. Tumor immunotherapy: preclinical and clinical activity of anti-CTLA4 antibodies. Curr Opin Investig Drugs 2005, 6:582-91.
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 582-591
-
-
Korman, A.1
Yellin, M.2
Keler, T.3
-
17
-
-
0344341626
-
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
-
Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A 2003, 100:4712-17.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4712-4717
-
-
Hodi, F.S.1
Mihm, M.C.2
Soiffer, R.J.3
Haluska, F.G.4
Butler, M.5
Seiden, M.V.6
-
18
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003, 100:8372-77.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8372-8377
-
-
Maker, A.V.1
Phan, G.Q.2
Attia, P.3
Yang, J.C.4
Sherry, R.M.5
Topalian, S.L.6
-
19
-
-
20044395957
-
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
-
Sanderson K, Scotland R, Lee P, Liu D, Groshen S, Snively J. Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol 2005, 23:741-50.
-
(2005)
J Clin Oncol
, vol.23
, pp. 741-750
-
-
Sanderson, K.1
Scotland, R.2
Lee, P.3
Liu, D.4
Groshen, S.5
Snively, J.6
-
20
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005, 23:6043-53.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
Phan, G.Q.2
Maker, A.V.3
Robinson, M.R.4
Quezado, M.M.5
Yang, J.C.6
-
21
-
-
28244492012
-
Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
-
Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol 2005, 175:7746-54.
-
(2005)
J Immunol
, vol.175
, pp. 7746-7754
-
-
Maker, A.V.1
Attia, P.2
Rosenberg, S.A.3
-
22
-
-
27844458057
-
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study
-
Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005, 12:1005-16.
-
(2005)
Ann Surg Oncol
, vol.12
, pp. 1005-1016
-
-
Maker, A.V.1
Phan, G.Q.2
Attia, P.3
Yang, J.C.4
Sherry, R.M.5
Topalian, S.L.6
-
23
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 2005, 23:8968-77.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8968-8977
-
-
Ribas, A.1
Camacho, L.H.2
Lopez-Berestein, G.3
Pavlov, D.4
Bulanhagui, C.A.5
Millham, R.6
-
24
-
-
34249017886
-
Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multi-peptide vaccine for resected stages IIIC and IV melanoma
-
Weber JS, Targan S, Scotland R, Snively J, Garcia M, Yellin M. Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multi-peptide vaccine for resected stages IIIC and IV melanoma. J Clin Oncol 2006, 24:Abstract 2510.
-
(2006)
J Clin Oncol
, vol.24
-
-
Weber, J.S.1
Targan, S.2
Scotland, R.3
Snively, J.4
Garcia, M.5
Yellin, M.6
-
25
-
-
41149164223
-
The efficacy and safety of ipilimumab (MDX-010) in patients with unresectable stage III or stage IV malignant melanoma
-
Weber JS, Hersh EM, Yellin M, Nichol GM, Urba W, Powderly JD. The efficacy and safety of ipilimumab (MDX-010) in patients with unresectable stage III or stage IV malignant melanoma. J Clin Oncol 2007, 25:Abstract 8523.
-
(2007)
J Clin Oncol
, vol.25
-
-
Weber, J.S.1
Hersh, E.M.2
Yellin, M.3
Nichol, G.M.4
Urba, W.5
Powderly, J.D.6
-
26
-
-
37049011353
-
Results of a phase II clinical trial of 2 doses and schedules of CP-675,206, an anti-CTLA4 monoclonal antibody, in patients (pts) with advanced melanoma
-
Ribas A, Antonia S, Sosman J, Kirkwood JM, Redman B, Gajewski TF. Results of a phase II clinical trial of 2 doses and schedules of CP-675,206, an anti-CTLA4 monoclonal antibody, in patients (pts) with advanced melanoma. J Clin Oncol 2007, 25:Abstract 3000.
-
(2007)
J Clin Oncol
, vol.25
-
-
Ribas, A.1
Antonia, S.2
Sosman, J.3
Kirkwood, J.M.4
Redman, B.5
Gajewski, T.F.6
-
27
-
-
55949137090
-
Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma
-
Ribas A, Hauschild A, Kefford R, Gomez-Navarro J, Pavlov D, Marshall MA. Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma. J Clin Oncol 2008, 26:Abstract LBA9011.
-
(2008)
J Clin Oncol
, vol.26
-
-
Ribas, A.1
Hauschild, A.2
Kefford, R.3
Gomez-Navarro, J.4
Pavlov, D.5
Marshall, M.A.6
-
28
-
-
36849035139
-
Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies
-
O'Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer 2007, 110:2614-27.
-
(2007)
Cancer
, vol.110
, pp. 2614-2627
-
-
O'Day, S.J.1
Hamid, O.2
Urba, W.J.3
-
29
-
-
33646886997
-
Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma
-
Reuben JM, Lee BN, Li C, Gomez-Navarro J, Bozon VA, Parker CA. Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma. Cancer 2006, 106:2437-44.
-
(2006)
Cancer
, vol.106
, pp. 2437-2444
-
-
Reuben, J.M.1
Lee, B.N.2
Li, C.3
Gomez-Navarro, J.4
Bozon, V.A.5
Parker, C.A.6
-
30
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 2006, 24:2283-9.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2283-2289
-
-
Beck, K.E.1
Blansfield, J.A.2
Tran, K.Q.3
Feldman, A.L.4
Hughes, M.S.5
Royal, R.E.6
-
31
-
-
37049014844
-
Natural history of diarrhea associated with the anti-CTLA4 monoclonal antibody CP-675,206
-
Antonia S, Sosman J, Kirkwood JM, Redman B, Gajewski TF, Pavlov D. Natural history of diarrhea associated with the anti-CTLA4 monoclonal antibody CP-675,206. J Clin Oncol 2007, 25:Abstract 3038.
-
(2007)
J Clin Oncol
, vol.25
-
-
Antonia, S.1
Sosman, J.2
Kirkwood, J.M.3
Redman, B.4
Gajewski, T.F.5
Pavlov, D.6
-
32
-
-
27444440093
-
Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
-
Blansfield JA, Beck KE, Tran K, Yang JC, Hughes MS, Kammula US. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 2005, 28:593-8.
-
(2005)
J Immunother
, vol.28
, pp. 593-598
-
-
Blansfield, J.A.1
Beck, K.E.2
Tran, K.3
Yang, J.C.4
Hughes, M.S.5
Kammula, U.S.6
-
33
-
-
55949122351
-
Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody
-
Hodi FS, Hoos A, Ibrahim R, Chin K, Pehamberger H, Harmankaya K. Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody. J Clin Oncol 2008, 26:Abstract 3008.
-
(2008)
J Clin Oncol
, vol.26
-
-
Hodi, F.S.1
Hoos, A.2
Ibrahim, R.3
Chin, K.4
Pehamberger, H.5
Harmankaya, K.6
-
34
-
-
55949094210
-
Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma
-
Weber JS, Berman D, Siegel J, Minor D, Amin A, Thompson JA. Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma. J Clin Oncol 2008, 26:Abstract 9010.
-
(2008)
J Clin Oncol
, vol.26
-
-
Weber, J.S.1
Berman, D.2
Siegel, J.3
Minor, D.4
Amin, A.5
Thompson, J.A.6
-
35
-
-
55949092508
-
Efficacy and safety of ipilimumab induction and maintenance dosing in patients with advanced melanoma who progressed on one or more prior therapies
-
O'Day SJ, Ibrahim R, DePril V, Maio M, Chiarion-Sileni V, Gajewski TF. Efficacy and safety of ipilimumab induction and maintenance dosing in patients with advanced melanoma who progressed on one or more prior therapies. J Clin Oncol 2008, 26:Abstract 9021.
-
(2008)
J Clin Oncol
, vol.26
-
-
O'Day, S.J.1
Ibrahim, R.2
DePril, V.3
Maio, M.4
Chiarion-Sileni, V.5
Gajewski, T.F.6
-
36
-
-
59149090272
-
Antitumor response and new lesions in advanced melanoma patients on ipilimumab treatment
-
Wolchok JD, Ibrahim R, DePril V, Maio M, Queirolo P, Harmankaya K. Antitumor response and new lesions in advanced melanoma patients on ipilimumab treatment. J Clin Oncol 2008, 26:Abstract 3020.
-
(2008)
J Clin Oncol
, vol.26
-
-
Wolchok, J.D.1
Ibrahim, R.2
DePril, V.3
Maio, M.4
Queirolo, P.5
Harmankaya, K.6
-
37
-
-
55949133643
-
Dose effect of ipilimumab in patients with advanced melanoma: results from a phase II, randomized, dose-ranging study
-
Hamid O, Chin K, Li J, Neyns B, Linette G, Negrier S. Dose effect of ipilimumab in patients with advanced melanoma: results from a phase II, randomized, dose-ranging study. J Clin Oncol 2008, 26:Abstract 9025.
-
(2008)
J Clin Oncol
, vol.26
-
-
Hamid, O.1
Chin, K.2
Li, J.3
Neyns, B.4
Linette, G.5
Negrier, S.6
-
38
-
-
42949105127
-
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
-
Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008, 105:3005-10.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3005-3010
-
-
Hodi, F.S.1
Butler, M.2
Oble, D.A.3
Seiden, M.V.4
Haluska, F.G.5
Kruse, A.6
|