Synthesis, X-ray structures and cytotoxic activity of platinum(II), palladium(II) and copper(II) complexes with chelating ligands

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2613-2621

  Budzisz, Elzbieta ^a   Miernicka, Magdalena ^a   Lorenz, Ingo Peter ^b   Mayer, Peter ^b   Balcerczak, Ewa ^a   Krajewska, Urszula ^a   Rozalski, Marek ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cytotoxic effect; Expression of BAX P53; Metal(II) complexes; Pyrazole ligands; Synthesis; X ray structure

Indexed keywords

1 (6 CHLOROPYRIDAZIN 3 YL) 3 METHYL 1H CHROMENO[4,3 C]PYRAZOL 4 ONE; 1 (6 CHLOROPYRIDAZIN 3 YL) 5 (2 HYDROXYPHENYL) 3 METHYL 1H PYRAZOLE 4 CARBOXYLIC ACID METHYL ESTER; 1 BENZOTHIAZOL 2 YL 3 METHYL 1H CHROMENO[4,3 C]PYRAZOL 4 ONE; 1 BENZOTHIAZOL 2 YL 5 (2 HYDROXYPHENYL) 3 METHYL 1H PYRAZOLE 4 CARBOXYLIC ACID METHYL ESTER; 2 METHYL 4 OXO 4H CHROMENE 3 CARBOXYLIC ACID METHYL ESTER; ANTINEOPLASTIC AGENT; CARBOPLATIN; CHELATING AGENT; CISPLATIN; COPPER COMPLEX; HYDRAZINE DERIVATIVE; PALLADIUM COMPLEX; PLATINUM COMPLEX; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MELANOMA CELL; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL LINE, TUMOR; CHELATING AGENTS; COPPER; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGANDS; ORGANOMETALLIC COMPOUNDS; PALLADIUM; PLATINUM; SPECTRUM ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950813609     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.050     Document Type: Article

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