Platinum(II) and palladium(II) complexes with 2-acetyl pyridine 4N-ethyl thiosemicarbazone able to overcome the cis-platin resistance. Structure, antibacterial activity and DNA strand breakage

BioMetals

Volumn 16, Issue 3, 2003, Pages 411-418

  Kovala Demertzi, Dimitra ^a   Demertzis, Mavroudis A ^a   Filiou, Eleni ^b   Pantazaki, Anastasia A ^b   Yadav, Paras N ^a   Miller, John R ^a   Zheng, Yifan ^c   Kyriakidis, Dimitrios A ^b  

^a UNIVERSITY OF IOANNINA   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Crystal structure; In vitro antibacterial study; In vitro DNA alterations; Palladium(II) complexes; Platinum(II); Thiosemicarbazonato complexes

Indexed keywords

2 ACETYLPYRIDINE 4 N ETHYLTHIOSEMICARBAZONE; 2 ACETYLPYRIDINE THIOSEMICARBAZONE; CISPLATIN; PALLADIUM COMPLEX; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; DRUG POTENCY; DRUG RESISTANCE; ELECTRON TRANSPORT; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR STABILITY; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; CELL DIVISION; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DNA DAMAGE; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, AGAR GEL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HYDROGEN BONDING; LIGANDS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS; PALLADIUM; PLATINUM; THIOSEMICARBAZONES;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0037412037     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022543718598     Document Type: Article

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