Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell

2nd International Conference on Biomedical and Pharmaceutical Engineering, ICBPE 2009 - Conference Proceedings

Volumn , Issue , 2009, Pages

  Li, P Y ^a   Lai, P S ^a   Lin, C C ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER CELLS; CANCER CELLS; CANCER TISSUES; CHEMOTHERAPY AGENTS; CLINICAL PROBLEMS; DOXORUBICIN; DRUG RESISTANCE; IN-VITRO; INTRACELLULAR DISTRIBUTION; MULTIDRUG RESISTANCE; NUCLEAR ACCUMULATION; PASSIVE TARGETING; POLY (L-LACTIDE); VITAMIN-E;

CELLS; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; MICELLES;

ORGANIC POLYMERS;

EID: 77950807134     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ICBPE.2009.5384064     Document Type: Conference Paper

References (21)

1. Batrakova, E.V., and Kabanov, A.V.: 'Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers', Journal of Controlled Release, 2008, 130, (2), pp. 98-106
2. Armstrong, A., Brewer, J., Newman, C., Alakhov, V., Pietrzynski, G., Campbell, S., Corrie, P., Ranson, M., and Valle, J.W.: 'SP1049C as first-line therapy in advanced (inoperable or metastatic) adenocarcinoma of the oesophagus: A phase II window study', J Clin Oncol (Meeting Abstracts), 2006, 24, (18-suppl), pp. 4080-
3. Zhang, Z., and Feng, S.-S.: 'Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: Synthesis, formulation, characterization and in vitro drug release', Biomaterials, 2006, 27, (2), pp. 262-270
4. Dintaman, J.M., and Silverman, J.A.: 'Inhibition of P-Glycoprotein by D-a-Tocopheryl Polyethylene Glycol 100 Succinate (TPGS)', Pharmaceutical Research, 1999, 16, (10), pp. 1550-1556
5. Varma, M.V.S., and Panchagnula, R.: 'Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo', European Journal of Pharmaceutical Sciences, 2005, 25, (4-5), pp. 445-453
6. Collnot, E.-M., Baldes, C., Wempe, M.F., Kappl, R., Huttermann, J., Hyatt, J.A., Edgar, K.J., Schaefer, U.F., and Lehr, C.-M.: 'Mechanism of Inhibition of P-Glycoprotein Mediated Efflux by Vitamin E TPGS: Influence on ATPase Activity and Membrane Fluidity', Molecular Pharmaceutics, 2007, 4, (3), pp. 465-474
7. Torchilin, V.P.: 'Multifunctional nanocarriers', Advanced Drug Delivery Reviews, 2006, 58, (14), pp. 1532-1555
8. Carstens, M.G., Rijcken, C.J.F., Nostrum, C.F., and Hennink, W.E.: 'Pharmaceutical Micelles: Combining Longevity, Stability, and Stimuli Sensitivity': 'Multifunctional Pharmaceutical Nanocarriers' (2008), pp. 263-308
9. Gaucher, G., Dufresne, M.-H., Sant, V.P., Kang, N., Maysinger, D., and Leroux, J.-C.: 'Block copolymer micelles: preparation, characterization and application in drug delivery', Journal of Controlled Release, 2005, 109, (1-3), pp. 169-188
10. Gottesman, M.M., and Pastan, I.: 'Biochemistry of multidrug-resistance mediated by the multidrug transporter', Annual Review of Biochemistry, 1993, 62, pp. 385-427
11. Bellamy, W.T.: 'P-glycoproteins and multidrug resistance', Annual Review of Pharmacology and Toxicology, 1996, 36, pp. 161-183
12. Kim, I.W., Booth-Genthe, C., and Ambudkar, S.V.: 'Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1)', Mini-Reviews in Medicinal Chemistry, 2008, 8, (3), pp. 193-200
13. Thomas, H., and Coley, H.M.: 'Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein', Cancer Control, 2003, 10, pp. 159-165
14. Yang, T.-F., Chen, C.-N., Chen, M.-C., Lai, C.-H., Liang, H.-F., and Sung, H.-W.: 'Shell-crosslinked Pluronic L121 micelles as a drug delivery vehicle', Biomaterials, 2007, 28, (4), pp. 725-734
15. Chavanpatil, M.D., Khdair, A., Gerard, B., Bachmeier, C., Miller, D.W., Shekhar, M.P.V., and Panyam, J.: 'Surfactant-Polymer Nanoparticles Overcome P-Glycoprotein-Mediated Drug Efflux', Molecular Pharmaceutics, 2007, 4, (5), pp. 730-738
16. Gervasoni, J.E., Jr., Fields, S.Z., Krishna, S., Baker, M.A., Rosado, M., Thuraisamy, K., Hindenburg, A.A., and Taub, R.N.: 'Subcellular Distribution of Daunorubicin in P-Glycoprotein-positive and -negative Drug-resistant Cell Lines Using Laser-assisted Confocal Microscopy', Cancer Res, 1991, 51, (18), pp. 4955-4963
17. Weaver, J.L., Pine, P.S., Aszalos, A., Schoenlein, P.V., Currier, S.J., Padmanabhan, R., and Gottesman, M.M.: 'Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells', Experimental Cell Research, 1991, 196, (2), pp. 323-329
18. Coley HM, A.W., Twentyman PR, Workman P.: 'Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.', Br J Cancer., 1993, 67, (6), pp. 1316-1323
19. Peng, C.-L., Shieh, M.-J., Tsai, M.-H., Chang, C.-C., and Lai, P.-S.: 'Self-assembled star-shaped chlorin-core poly([var epsilon]-caprolactone)- poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies', Biomaterials, 2008, 29, (26), pp. 3599-3608
20. Lu, C., Liu, L., Guo, S.-R., Zhang, Y., Li, Z., and Gu, J.: 'Micellization and gelation of aqueous solutions of star-shaped PEG-PCL block copolymers consisting of branched 4-arm poly(ethylene glycol) and polycaprolactone blocks', European Polymer Journal, 2007, 43, (5), pp. 1857-1865
21. Tiberghien, F., and Loor, F.: 'Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay', Anti-Cancer Drugs, 1996, 7, (5), pp. 568-578