Protective effects of estrogen against reperfusion arrhythmias following severe myocardial ischemia in rats

Circulation Journal

Volumn 74, Issue 4, 2010, Pages 634-643

  Wang, Yan ^a   Wang, Qi ^a   Zhao, Yingnan ^b   Gong, Dezheng ^a   Wang, Dongmei ^a   Li, Cong ^a   Zhao, Henan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Center for Disease Control of Heilongjiang Province   (China)

Author keywords

Estrogen; Gap junction; Reperfusion arrhythmia

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; CALCIUM ION; CONNEXIN 43; DIARYLPROPIONITRILE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; VINCULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GAP JUNCTION; GENE EXPRESSION; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RHYTHM; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MALE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; RAT; REPERFUSION; REPERFUSION INJURY; SUPPLEMENTATION; UPREGULATION;

ANIMALS; APOPTOSIS; ARRHYTHMIAS, CARDIAC; CARDIAC COMPLEXES, PREMATURE; CONNEXIN 43; ELECTROCARDIOGRAPHY; ESTROGEN RECEPTOR BETA; ESTROGENS; GAP JUNCTIONS; INCIDENCE; MALE; MODELS, ANIMAL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TACHYCARDIA, VENTRICULAR; UP-REGULATION; VINCULIN;

EID: 77950663045     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.cj-09-0223     Document Type: Article

References (44)

1. Sezai A, Hata M, Wakui S, Niino T, Takayama T, Hirayama A, et al. Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Circ J 2007; 71: 1401-1407.
2. Goldberg S, Greenspon AJ, Urban PL, Muza B, Berger B, Walinsky P, et al. Reperfusion arrhythmia: A marker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction. Am Heart J 1983; 105: 26-32.
3. Ilia R, Zahger D, Cafri C, Abu-Ful A, Weinstein JM, Yaroslavtsev S, et al. Predicting survival with reperfusion arrhythmias during primary percutaneous coronary intervention for acute myocardial infarction. Isr Med Assoc J 2007; 9: 21-23.
4. Goldstein S, Landis JR, Leighton R, Ritter G, Vasu CM, Lantis A, et al. Characteristics of the resuscitated out-of-hospital cardiac arrest victim with coronary heart disease. Circulation 1981; 64: 977-984.
5. Sourander L, Rajala T, Räihä I, Mäkinen J, Erkkola R, Helenius H. Cardiovascular and cancer morbidity and mortality and sudden cardiac death in postmenopausal women on oestrogen replacement therapy (ERT). Lancet 1998; 352: 1965-1969.
6. Kim YD, Chen B, Beauregard J, Kouretas P, Thomas G, Farhat MY, et al. 17 beta-estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias after brief ischemia/reperfusion. Circulation 1996; 94: 2901-2908.
7. Blumenthal RS, Heldman AW, Brinker JA, Resar JR, Coombs VJ, Gloth ST, et al. Acute effects of conjugated estrogens on coronary blood flow response to acetylcholine in men. Am J Cardiol 1997; 80: 1021-1024.
8. Arnlov J, Pencina MJ, Amin S, Nam BH, Benjamin EJ, Murabito JM, et al. Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med 2006; 145: 176-184.
9. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, et al. The nuclear receptor superfamily: The second decade. Cell 1995; 83: 835-839.
10. Nikolic I, Liu D, Bell JA, Collins J, Steenbergen C, Murphy E. Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol 2007; 42: 769-780.
11. Yu HP, Shimizu T, Choudhry MA, Hsieh YC, Suzuki T, Bland KI, et al. Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteins. J Mol Cell Cardiol 2006; 40: 185-194.
12. Müge Tecder-ünal, Ýlker Kanzýkb. Peroxynitrite in reperfusion arrhythmias and its whole blood chemiluminescence results. Pharmacol Res 2004; 49: 7-16.
13. Wit AL, Janse MJ. Reperfusion arrhythmias and sudden cardiac death: A century of progress toward an understanding of the mechanisms. CircRes 2001; 89: 741-743.
14. Opitz CF, Finn PV, Pfeffer MA, Mitchell GF, Pfeffer JM. Effects of reperfusion on arrhythmias and death after coronary artery occlusion in the rat: Increased electrical stability independent of myocardial salvage. J Am Coll Cardiol 1998; 32: 261-267.
15. Stentz FB, Umpierrez GE, Cuervo R, Kitabchi AE. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 2004; 53: 2079-2086.
16. Rakotovao A, Tanguy S, Toufektsian MC, Berthonneche C, Ducros V, Tosaki A, et al. Selenium status as determinant of connexin-43 dephosphorylation in ex vivo ischemic/reperfused rat myocardium. J Trace Elem Med Biol 2005; 19: 43-47.
17. -1) and cardiac transcription factor GATA4 expression in rat's cardiac myocytes hypertrophy and apoptosis. Pathol Res Pract 2009; 205: 615-625.
18. Li J, Xing M, Zhu M, Wang X, Wang M, Zhou S, et al. Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization. CancerLett 2008; 272: 91-101.
19. Cascio WE, Yang H, Johnson TA, Muller-Borer BJ, Lemasters JJ. Electrical properties and conduction in reperfused papillary muscle. CircRes 2001; 89: 807-814.
20. Kato M, Dote K, Sasaki S, Ueda K, Nakano Y, Naganuma T, et al. Impact of metabolic syndrome on coronary plaque vulnerability in Japanese women with acute coronary syndrome. CircJ 2008; 72: 940-945.
21. Ueyama T, Ishikura F, Matsuda A, Asanuma T, Ueda K, Ichinose M, et al. Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart. CircJ 2007; 71: 565-573.
22. Papp R, Gönczi M, Kovács M, Seprényi G, Végh A. Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemic preconditioning. CardiovascRes 2007; 74: 396-405.
23. Chung TH, Wang SM, Wu JC. 17beta-estradiol reduces the effect of metabolic inhibition on gap junction intercellular communication in rat cardiomyocytes via the estrogen receptor. J Mol Cell Cardiol 2004; 37: 1013-1022.
24. Kanno S, Saffitz JE. The role of myocardial gap junctions in electrical conduction and arrhythmogenesis. CardiovascPathol 2001; 10: 169-177.
25. Liu BL, McGrath JJ. Effects of freezing on the cytoskeleton, focal adhesions and gap-junctions in murine osteoblast cultures. Conf Proc IEEEEng Med Biol Soc 2005; 5: 4896-4899.
26. Subauste MC, Nalbant P, Adamson ED, Hahn KM. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. JBiolChem 2005; 280: 5676-5681.
27. Bakolitsa C, Cohen DM, Bankston LA, Bobkov AA, Cadwell GW, Jennings L, et al. Structural basis for vinculin activation at sites of cell adhesion. Nature 2004; 430: 583-586.
28. Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, et al. Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res 2000; 87: 656-662.
29. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, et al. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol 2007; 27: 7522-7537.
30. Goubaeva F, Mikami M, Giardina S, Ding B, Abe J, Yang J. Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys ResCommun 2007; 352: 97-103.
31. Nakajima T, Iwasawa K, Oonuma H, Morita T, Goto A, Wang Y, et al. Antiarrhythmic effect and its underlying ionic mechanism of 17beta-estradiol in cardiac myocytes. Br J Pharmacol 1999; 127: 429-440.
32. Nakajima T, Ma J, Iida H, Iwasawa K, Jo T, Omata M, et al. Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Jpn Heart J 2003; 44: 963-978.
33. Goldhaber JI, Weiss JN. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 1992; 20: 118-127.
34. Cross HR, Kranias EG, Murphy E, Steenbergen C. Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: Protective role of NO. Am J Physiol Heart Circ Physiol 2003; 284: H683-H690.
35. Kim KH, Moriarty K, Bender JR. Vascular cell signaling by membrane estrogen receptors. Steroids 2008; 73: 864-869.
36. Kim KH, Bender JR. Membrane-initiated actions of estrogen on the endothelium. Mol Cell Endocrinol 2009; 308: 3-8.
37. Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 2009; 308: 32-38.
38. Bai CX, Kurokawa J, Tamagawa M, Nakaya H, Furukawa T. Nontranscriptional regulation of cardiac repolarization currents by testosterone. Circulation 2005; 112: 1701-1710.
39. Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, et al. Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization. JPhysiol 2008; 586: 2961-2973.
40. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. JMedChem 2000; 43: 4934-4947.
41. Förster C, Kietz S, Hultenby K, Warner M, Gustafsson JA. Characterization of the ERbeta-/-mouse heart. Proc Natl Acad Sci USA 2004; 101: 14234-14239.
42. Zhai P, Eurell TE, Cooke PS, Lubahn DB, Gross DR. Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice. Am J Physiol Heart Circ Physiol 2000; 278: H1640-H1647.
43. Ha JW, Lee HC, Park S, Choi EY, Seo HS, Shim CY, et al. Genderrelated difference in left ventricular diastolic elastance during exercise in patients with diabetes mellitus. CircJ 2008; 72: 1443-1448.
44. Wang M, Crisostomo P, Wairiuko GM, Meldrum DR. Estrogen receptor-alpha mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol 2006; 290: H2204-H2209