Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemic preconditioning

Cardiovascular Research

Volumn 74, Issue 3, 2007, Pages 396-405

  Papp, Rita ^a   Gönczi, Márton ^a   Kovács, Mária ^a   Seprényi, György ^a   Végh, Ágnes ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Connexin 43; Electrical impedance; Gap junctions; Preconditioning; Ventricular arrhythmias

Indexed keywords

CARBENOXOLONE; CHLORALOSE; CONNEXIN 43; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISEASE SEVERITY; DOG; DRUG EFFECT; EPICARDIUM; FEMALE; GAP JUNCTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; IMPEDANCE; INTRACORONARY INFUSION; ISCHEMIC PRECONDITIONING; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; ST SEGMENT; THORACOTOMY;

ANIMALS; ARRHYTHMIA; BLOTTING, WESTERN; CARBENOXOLONE; CELL COMMUNICATION; CONNEXIN 43; DOGS; ELECTRIC IMPEDANCE; FEMALE; GAP JUNCTIONS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; UNCOUPLING AGENTS;

EID: 34247850423     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2007.02.021     Document Type: Article

References (47)

1. Kaplinsky E., Ogawa S., Balke C.W., and Dreifus L.S. Two periods of early ventricular arrhythmias in the canine acute myocardial infarction model. Circulation 60 (1979) 397-403
2. Janse M.J., and Kléber A.G. Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia. Circ Res 49 (1981) 1069-1081
3. Kléber A.G., and Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Phys Rev 81 (2004) 431-488
4. Kléber A.G., Janse M.J., Wilms-Schopman F.J.G., Wilde A.A.M., and Coronel R. Changes in conduction velocity during acute ischaemia in ventricular myocardium of the isolated porcine heart. Circ Res 73 (1986) 189-198
5. Wilde A.A.M., and Asknes G. Myocardial potassium loss and cell depolarisation in ischemia and hypoxia. Cardiovasc Res 29 (1995) 1-15
6. Janse M.J., and Kléber A.G. Propagation of electrical activity in ischemic and infarcted myocardium as the basis of ventricular arrhythmias. J Cardiovasc Electrophysiol 3 (1992) 77-87
7. Russell D.C., Lawrie J.S., Riemersma R.A., and Oliver M.F. Mechanisms of phase 1a and 1b early ventricular arrhythmias during acute myocardial ischemia in the dog. Am J Cardiol 53 (1984) 307-312
8. Végh Á., Komori S., Szekeres L., and Parratt J.R. Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats. Cardiovasc Res 26 (1992) 487-495
9. Kléber A.G., Riegger C.B., and Janse M.J. Electrical uncoupling and increase in extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. Circ Res 61 (1987) 271-279
10. Smith W.T., Fleet W.F., Johnson T.A., Engle C.L., and Cascio W.E. The 1b phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Circulation 92 (1995) 3051-3060
11. Scherlag B.J., El-Sherif N., Hope R.R., and Lazzara R. Characterization and localization of ventricular arrhythmias resulting from myocardial ischemia and infarction. Circ Res 35 (1974) 372-383
12. Cinca J., Warren M., Careno A., Tresanchez M., Armadans L., Gomez P., et al. Changes in myocardial electrical impedance induced by coronary artery occlusion in pigs with and without preconditioning. Circulation 96 (1997) 3079-3086
13. DeGroot J.R., and Coronel R. Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis. Cardiovasc Res 62 (2004) 323-334
14. Saltman A.E., Aksehirli T.O., Valiunas V., Gaudette G.R., Matsuyama N., Brink P., et al. Gap junction uncoupling protects the heart against ischemia. J Thorac Cardiovasc Surg 124 (2002) 371-376
15. Rodriguez-Sinovas A., Gardia-Dorado D., Ruiz-Meana M., and Soler-Soler J. Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts. Am J Physiol 290 (2005) H648-H656
16. Li G., Whittaker P., Yao M., Kloner R.A., and Przyklenk K. The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc Pathol 11 (2002) 158-165
17. Christ G.J., Spektor M., Brink P.R., and Barr L. Further evidence for the selective disruption of intercellular communication by heptanol. Am J Physiol 276 (1999) H1911-H1917
18. DeGroot J., Veenstra T., Verkerk A.O., Wilders R., Smits J.P.P., Wilms-Schopman F.J.G., et al. Conduction slowing by the gap junction uncoupler carbenoxolone. Cardiovasc Res 60 (2003) 288-297
19. Nagayama S., Jono H., Suzaki H., Sakai K., Tsuruya E., Yamatsu I., et al. Carbenoxolone, a new inducer of heat shock protein 70. Life Sci 69 (2001) 2867-2873
20. Takeda Y., Ward S.M., Sanders K.M., and Koh S.D. Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells. Am J Physiol 288 (2005) G832-G841
21. Guo Y., Martinez-Williams C., Gilbert K.A., and Rannels D.E. Inhibition of gap junction communication in alveolar epithel cells by 18α-glycyrrhetinic acid. Am J Physiol 276 (1999) L1018-L1026
22. Papp R., Gönczi M., and Végh Á. Carbenoxolone attenuates the antiarrhythmic effect of preconditioning. Further evidence from in vivo measurements of gap junctional uncoupling. J Mol Cell Cardiol 40 979 (2006) A161 [abstract]
23. Papp R., Gönczi M., and Végh Á. Carbenoxolone, a gap junction uncoupler, mimics the antiarrhythmic effects of ischaemic preconditioning. Eur Heart J 27 306 (2006) A1819 [abstract]
24. Williams D.O., Scherlag B.J., Hope R.R., El-Sherif N., and Lazzara R. The pathophysiology of malignant ventricular arrhythmias during acute myocardial ischemia. Circulation 50 (1974) 1163-1172
25. Padilla F., Garcia-Dorado D., Rodriguez-Sinovas A., Ruiz-Meana M., Inserte J., and Soler-Soler J. Protection afforded by ischemic preconditioning is not mediated by effects on cell-to-cell electrical coupling during myocardial ischemia-reperfusion. Am J Physiol 285 (2003) H1909-H1916
26. Ruiz-Meana M., Garcia-Dorado D., Lane S., Pina P., Inserte J., Mirabet M., et al. Persistence of gap junction communication during myocardial ischemia. Am J Physiol 280 (2001) H2563-H2571
27. ATP channels in the antiarrhythmic effects of ischaemic preconditioning in dogs. Br J Pharmacol 137 (2002) 107-115
28. Schulz R., Gres P., Skyschally A., Duschin A., Belosjorow S., Konietzka I., et al. Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo. FASEB J 17 (2003) 1355-1357
29. Garcia-Dorado D., Ruiz-Meana M., Padilla F., Rodriguez-Sinovas A., and Mirabet M. Gap junction-mediated intercellular communication in ischemic preconditioning. Cardiovasc Res 55 (2002) 456-465
30. Kaszala K., Végh Á., Papp J.G.Y., and Parratt J.R. Time course of the protection against ischaemia and reperfusion induced ventricular arrhythmias resulting from brief periods of cardiac pacing. J Mol Cell Cardiol 28 (1996) 2085-2095
31. Babai L., Szigeti Z.S., Parratt J.R., and Végh Á. Delayed cardioprotective effects of exercise in dogs are aminoguanidine sensitive: possible involvement of nitric oxide. Clin Sci 102 (2002) 435-445
32. Kléber A.G. Conduction of the impulse in the ischemic myocardium: implications for malignant ventricular arrhythmias. Experimentia 43 (1987) 1056-1061
33. Rohr S., Kucera J.P., and Kléber A.G. Slow conduction in cardiac tissue: I. Effects on a reduction of excitability versus a reduction of electrical coupling on microconduction. Circ Res 83 (1998) 781-794
34. Jongsma H.J., and Wilders R. Gap junctions in cardiovascular disease. Circ Res 86 (2000) 1193-1197
35. Daleau P., Boudriau S., Michaud M., Jolicoeur C., and Kingma J.G. Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution. Can J Physiol Pharm 79 (2001) 371-378
36. Vetterlein F., Mühlfeld C., Cetegen C., Volkmann R., Schrader C., and Hellige G. Redistribution of connexin 43 in regional acute ischemic myocardium: influence of ischemic preconditioning. Am J Physiol 291 (2006) H813-H819
37. Jain S.K., Schuessler R.B., and Saffitz J.E. Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning. Circ Res 92 (2003) 1138-1144
38. De Groot J.R., and Coronel R. Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis. Cardiovasc Res 62 (2004) 323-334
39. Lazzara R., El-Sherif N., Hope R.R., and Scherlag B.J. Ventricular arrhythmias and electrophysiological consequences of myocardial ischemia and infarction. Circ Res 42 (1978) 740-749
40. Plotkin L.I., Manolagas S.C., and Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277 (2002) 8648-8657
41. Lampe P.D., and Lau A.F. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol (2004) 1171-1186
42. Beardslee M.A., Lerner D.L., Tadros P.N., Laing J.G., Beyer E.C., Yamada K.A., et al. Dephosphorylation and intracellular redistribution of ventricular connexin 43 during electrical uncoupling induced by ischemia. Circ Res 87 (2000) 656-662
43. 2 receptors. Br J Pharmacol 113 (1994) 1167-1172
44. Végh Á., Szekeres L., and Parratt J.R. Preconditioning of the ischaemic myocardium; involvement of the l-arginine-nitric oxide pathway. Br J Pharmacol 107 (1992) 648-652
45. Ping P., Zhang J., Pierce Jr. W.M., and Bolli R. Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardiopotection. Circ Res 88 (2001) 59-62
46. Li G.C., Vasquez J.A., Gallagher K.P., and Lucchesi B.R. Myocardial protection with preconditioning. Circulation 82 (1990) 609-619
47. Pomar F., Cosin J., Portoles M., Faura M., Renau-Piqueras J., Hernandiz A., et al. Functional and ultrastructural alterations of canine myocardium subjected to very brief coronary occlusions. Eur Heart J 60 (1995) 1482-1490