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Volumn , Issue , 2008, Pages 25-44

Clinical Relevance of Pseudomonas aeruginosa: A Master of Adaptation and Survival Strategies

Author keywords

Adaptation; Antibiotic therapy; Clinical relevance; Evolutionary implications; Lung conductive zones; Lung respiratory zones; Pseudomonas aeruginosa; Survival strategies

Indexed keywords


EID: 77950630705     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527622009.ch2     Document Type: Chapter
Times cited : (4)

References (99)
  • 1
    • 0020533146 scopus 로고
    • Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a cystic fibrosis clinic
    • Zimakoff, J., Høiby, N., Rosendal, K. and Guilbert, J.P. (1983) Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a cystic fibrosis clinic. J Hosp Infect, 4, 31-40.
    • (1983) J Hosp Infect , vol.4 , pp. 31-40
    • Zimakoff, J.1    Høiby, N.2    Rosendal, K.3    Guilbert, J.P.4
  • 2
    • 0003770442 scopus 로고
    • Pseudomonas aeruginosa as an Opportunistic Pathogen
    • Plenum Press, New York.
    • Campa, M., Bendinelli, M. and Friedman, H. (1993) Pseudomonas aeruginosa as an Opportunistic Pathogen, Plenum Press, New York.
    • (1993)
    • Campa, M.1    Bendinelli, M.2    Friedman, H.3
  • 5
    • 0347504933 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa chromosomal b-lactamase in patients with cystic fibrosis and chronic lung infection -mechanism of antibiotic resistance and target of the humoral immune response
    • Ciofu, O. (2003) Pseudomonas aeruginosa chromosomal b-lactamase in patients with cystic fibrosis and chronic lung infection -mechanism of antibiotic resistance and target of the humoral immune response. APMIS, 111, 4-47.
    • (2003) APMIS , vol.111 , pp. 4-47
    • Ciofu, O.1
  • 6
    • 9644274002 scopus 로고    scopus 로고
    • National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993-2002
    • Obritsch, M., Fish, DN., Maclaren, R. and Jung, R. (2004) National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993-2002. Antimicrob Agents Chemother, 48, 4606-4610.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4606-4610
    • Obritsch, M.1    Fish, D.N.2    Maclaren, R.3    Jung, R.4
  • 7
    • 15744366167 scopus 로고    scopus 로고
    • Management of febrile neutropenia: current strategies
    • Bodey, GP. (2005) Management of febrile neutropenia: current strategies. Clin Infect Dis, 40 (Suppl 4), s237-s358.
    • (2005) Clin Infect Dis , vol.40 , Issue.SUPPL 4
    • Bodey, G.P.1
  • 8
    • 12944295224 scopus 로고    scopus 로고
    • Bloodstream infections caused by antibiotic-resistant Gramnegative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome
    • Kang, C.-I., Kim, S.-H., Park, WB., Lee, K.-D., Kim, H.-B., Kim, E.-C., Oh, M. and Choe, K.-W. (2005) Bloodstream infections caused by antibiotic-resistant Gramnegative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother, 49, 760-766.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 760-766
    • Kang, C.-I.1    Kim, S.-H.2    Park, W.B.3    Lee, K.-D.4    Kim, H.-B.5    Kim, E.-C.6    Oh, M.7    Choe, K.-W.8
  • 9
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • Russell, JA. (2006) Management of sepsis. N Engl J Med, 355, 1699-1713.
    • (2006) N Engl J Med , vol.355 , pp. 1699-1713
    • Russell, J.A.1
  • 12
    • 0346505482 scopus 로고    scopus 로고
    • New concepts of the pathogenesis of cystic fibrosis lung disease
    • Boucher, R.C. (2004) New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J, 23, 146-158.
    • (2004) Eur Respir J , vol.23 , pp. 146-158
    • Boucher, R.C.1
  • 14
    • 0032828524 scopus 로고    scopus 로고
    • The changing epidemiology of Pseudomonas aeruginosa infection in Danish cystic fibrosis patients 1974-1995
    • Frederiksen, B., Koch, C. and Høiby, N. (1999) The changing epidemiology of Pseudomonas aeruginosa infection in Danish cystic fibrosis patients 1974-1995. Pediatr Pulmonol, 28, 159-166.
    • (1999) Pediatr Pulmonol , vol.28 , pp. 159-166
    • Frederiksen, B.1    Koch, C.2    Høiby, N.3
  • 15
    • 33846320868 scopus 로고    scopus 로고
    • P aeruginosa in cystic fibrosis patients resists host defenses, antibiotics
    • Høiby, N. (2006) P aeruginosa in cystic fibrosis patients resists host defenses, antibiotics. Microbe, 1, 571-577.
    • (2006) Microbe , vol.1 , pp. 571-577
    • Høiby, N.1
  • 16
    • 0031029702 scopus 로고    scopus 로고
    • Role of oxidants in microbial pathophysiology
    • Miller, R.A. and Britigan, B.E. (1997) Role of oxidants in microbial pathophysiology. Clin Microbiol Rev, 10, 1-18.
    • (1997) Clin Microbiol Rev , vol.10 , pp. 1-18
    • Miller, R.A.1    Britigan, B.E.2
  • 17
    • 0030802906 scopus 로고    scopus 로고
    • Pulmonary oxidative stress response in young children with cystic fibrosis
    • Hull, J., Vervaart, P., Grimwood, K. and Phelan, P. (1997) Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax, 52, 557-560.
    • (1997) Thorax , vol.52 , pp. 557-560
    • Hull, J.1    Vervaart, P.2    Grimwood, K.3    Phelan, P.4
  • 20
    • 0030034915 scopus 로고    scopus 로고
    • Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA
    • Boucher, J.C., Martinezsalazar, J., Schurr, M.J., Mudd, M.H., Yu, H. and Deretic, V. (1996) Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA. J Bacteriol, 178, 511-523.
    • (1996) J Bacteriol , vol.178 , pp. 511-523
    • Boucher, J.C.1    Martinezsalazar, J.2    Schurr, M.J.3    Mudd, M.H.4    Yu, H.5    Deretic, V.6
  • 21
    • 33750962335 scopus 로고    scopus 로고
    • Sequence diversity of the mucoid mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Bragonzi, A., Wiehlmann, L., Klockgether, J., Cramer, N., Worlizsch, D., Döring, G. and Tümmler,B. (2006) Sequence diversity of the mucoid mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Microbiology, 152, 3261-3269.
    • (2006) Microbiology , vol.152 , pp. 3261-3269
    • Bragonzi, A.1    Wiehlmann, L.2    Klockgether, J.3    Cramer, N.4    Worlizsch, D.5    Döring, G.6    Tümmler, B.7
  • 22
    • 0141650541 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa alginate is refractory to Th1 immune, response and impedes host immune clearance in a mouse model of acute lung infection
    • Song, Z.J., Wu, H., Ciofu, O., Kong, K.F., Høiby, N., Rygaard, J., Kharazmi, A. and Mathee, K. (2003) Pseudomonas aeruginosa alginate is refractory to Th1 immune, response and impedes host immune clearance in a mouse model of acute lung infection. J Med Microbiol, 52, 731-740.
    • (2003) J Med Microbiol , vol.52 , pp. 731-740
    • Song, Z.J.1    Wu, H.2    Ciofu, O.3    Kong, K.F.4    Høiby, N.5    Rygaard, J.6    Kharazmi, A.7    Mathee, K.8
  • 23
    • 19544386997 scopus 로고    scopus 로고
    • Occurrence of hypermutable P aeruginosa in cystic fibrosis patients is associates with the oxidative stress caused by chronic lung inflammation
    • Ciofu, O., Riis, B., Pressler, T., Poulsen, H.E. and Høiby, N. (2005) Occurrence of hypermutable P aeruginosa in cystic fibrosis patients is associates with the oxidative stress caused by chronic lung inflammation. Antimicrob Agents Chemother, 49, 2276-2282.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2276-2282
    • Ciofu, O.1    Riis, B.2    Pressler, T.3    Poulsen, H.E.4    Høiby, N.5
  • 29
    • 0001981058 scopus 로고
    • Airway biofilm disease: its clinical manifestation and therapeutic possibilities of macrolides
    • Kobayashi, H. (1995) Airway biofilm disease: its clinical manifestation and therapeutic possibilities of macrolides. J Infect Chemother, 1, 1-15.
    • (1995) J Infect Chemother , vol.1 , pp. 1-15
    • Kobayashi, H.1
  • 31
    • 3343023861 scopus 로고    scopus 로고
    • Early intervention and prevention of lung disease in cystic fibrosis: a European consensus
    • Döring, G. and Høiby, N. (2004) Early intervention and prevention of lung disease in cystic fibrosis: a European consensus. J Cystic Fibrosis, 3, 67-91.
    • (2004) J Cystic Fibrosis , vol.3 , pp. 67-91
    • Döring, G.1    Høiby, N.2
  • 33
    • 31344462167 scopus 로고    scopus 로고
    • Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection -a case control study
    • Pressler, T., Frederiksen, B., Skov, M., Garred, P., Koch, C. and Høiby, N. (2006) Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection -a case control study. J Cystic Fibrosis, 5, 9-15.
    • (2006) J Cystic Fibrosis , vol.5 , pp. 9-15
    • Pressler, T.1    Frederiksen, B.2    Skov, M.3    Garred, P.4    Koch, C.5    Høiby, N.6
  • 34
    • 23644439540 scopus 로고    scopus 로고
    • Eradication of early Pseudomonas aeruginosa infection
    • Høiby, N., Frederiksen, B. and Pressler, T. (2005) Eradication of early Pseudomonas aeruginosa infection. J Cystic Fibrosis, 4, 49-54.
    • (2005) J Cystic Fibrosis , vol.4 , pp. 49-54
    • Høiby, N.1    Frederiksen, B.2    Pressler, T.3
  • 36
    • 27644536101 scopus 로고    scopus 로고
    • Pulmonary Physiology and Pathophysiology
    • Lippincott Williams& Wilkins, Philadelphia, PA.
    • Westh, J.B. (2001) Pulmonary Physiology and Pathophysiology, Lippincott Williams& Wilkins, Philadelphia, PA.
    • (2001)
    • Westh, J.B.1
  • 37
    • 0020634472 scopus 로고
    • Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis
    • Permin, H., Koch, C., Høiby, N., Christensen, H.O., Møller, A.F. and Møller, S. (1983) Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis. J Antimicrob Chemother, 12 (Suppl A), 313-323.
    • (1983) J Antimicrob Chemother , vol.12 , Issue.SUPPL A , pp. 313-323
    • Permin, H.1    Koch, C.2    Høiby, N.3    Christensen, H.O.4    Møller, A.F.5    Møller, S.6
  • 38
    • 0021253893 scopus 로고
    • Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study
    • Levy, J., Smith, A.L., Koup, J.R., Williams-Warren, J. and Ramsey, B. (1984) Disposition of tobramycin in patients with cystic fibrosis: a prospective controlled study. J Pediatr, 105, 117-124.
    • (1984) J Pediatr , vol.105 , pp. 117-124
    • Levy, J.1    Smith, A.L.2    Koup, J.R.3    Williams-Warren, J.4    Ramsey, B.5
  • 41
    • 0036304163 scopus 로고    scopus 로고
    • Pharmacokinetics bioavailability of aerosolized tobramycin in cystic fibrosis
    • Geller, D.E., Pitlick, W.H., Nardella, P.A., Tracewell, W.G. and Ramsey, B.W. (2002) Pharmacokinetics bioavailability of aerosolized tobramycin in cystic fibrosis. Chest 122, 219-226.
    • (2002) Chest , vol.122 , pp. 219-226
    • Geller, D.E.1    Pitlick, W.H.2    Nardella, P.A.3    Tracewell, W.G.4    Ramsey, B.W.5
  • 42
    • 78650216875 scopus 로고    scopus 로고
    • Optimization of Antibiotic Inhalation Therapy in Cystic Fibrosis. Studies on Nebulized Tobramycin
    • Development of a Colistin Dry Powder Inhaler System. University of Groningen.
    • Le Brun, P.P.H. (2001) Optimization of Antibiotic Inhalation Therapy in Cystic Fibrosis. Studies on Nebulized Tobramycin. Development of a Colistin Dry Powder Inhaler System. University of Groningen.
    • (2001)
    • Le Brun, P.P.H.1
  • 43
    • 0023265976 scopus 로고
    • Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
    • Jensen, T., Pedersen, S.S., Garne, S., Heilmann, C., Høiby, N. and Koch, C. (1987) Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. J Antimicrob Chemother, 19, 831-838.
    • (1987) J Antimicrob Chemother , vol.19 , pp. 831-838
    • Jensen, T.1    Pedersen, S.S.2    Garne, S.3    Heilmann, C.4    Høiby, N.5    Koch, C.6
  • 44
    • 0025868478 scopus 로고
    • Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment
    • Valerius, N.H., Koch, C. and Høiby, N. (1991) Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment. Lancet, 338, 725-726.
    • (1991) Lancet , vol.338 , pp. 725-726
    • Valerius, N.H.1    Koch, C.2    Høiby, N.3
  • 45
    • 0242330233 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (NOS II) is constitutive in human neutrophils
    • Cedergren, J., Follin, P., Forslund, T., Lindmark, M., Sundquist, T. and Skogh, T. (2003) Inducible nitric oxide synthase (NOS II) is constitutive in human neutrophils. APMIS, 111, 963-968.
    • (2003) APMIS , vol.111 , pp. 963-968
    • Cedergren, J.1    Follin, P.2    Forslund, T.3    Lindmark, M.4    Sundquist, T.5    Skogh, T.6
  • 47
    • 0025266577 scopus 로고
    • Immunoglobulin-A and immunoglobulin-G antibody responses to alginates from Pseudomonas aeruginosa in patients with cystic fibrosis
    • Pedersen, S.S., Espersen, F., Høiby, N. and Jensen, T. (1990) Immunoglobulin-A and immunoglobulin-G antibody responses to alginates from Pseudomonas aeruginosa in patients with cystic fibrosis. J Clin Microbiol, 28, 747-755.
    • (1990) J Clin Microbiol , vol.28 , pp. 747-755
    • Pedersen, S.S.1    Espersen, F.2    Høiby, N.3    Jensen, T.4
  • 48
    • 0025006851 scopus 로고
    • Pseudomonas aeruginosa alginate in cystic fibrosis sputum and the inflammatory response
    • Pedersen, S.S., Kharazmi, A., Espersen, F. and Høiby, N. (1990) Pseudomonas aeruginosa alginate in cystic fibrosis sputum and the inflammatory response. Infect Immun, 58, 3363-3368.
    • (1990) Infect Immun , vol.58 , pp. 3363-3368
    • Pedersen, S.S.1    Kharazmi, A.2    Espersen, F.3    Høiby, N.4
  • 49
    • 0022485439 scopus 로고
    • Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis
    • Goldstein, W. and Döring, G. (1986) Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis. Am Rev Respir Dis, 134, 49-56.
    • (1986) Am Rev Respir Dis , vol.134 , pp. 49-56
    • Goldstein, W.1    Döring, G.2
  • 50
    • 0021783739 scopus 로고
    • Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis
    • Bruce, M.C., Poncz, L., Klinger, J.D., Stern, R.C., Tomashefski, J.F. and Dearborn, D.G. (1985) Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis. Am Rev Respir Dis, 132, 529-535.
    • (1985) Am Rev Respir Dis , vol.132 , pp. 529-535
    • Bruce, M.C.1    Poncz, L.2    Klinger, J.D.3    Stern, R.C.4    Tomashefski, J.F.5    Dearborn, D.G.6
  • 51
    • 0024253870 scopus 로고
    • Excretion of urinary collagen metabolites correlates to severity of pulmonary disease in cystic fibrosis
    • Ammitzbøll, T., Pedersen, S.S., Espersen, F. and Schiøler, H. (1988) Excretion of urinary collagen metabolites correlates to severity of pulmonary disease in cystic fibrosis. Acta Paediatr Scand, 77, 842-846.
    • (1988) Acta Paediatr Scand , vol.77 , pp. 842-846
    • Ammitzbøll, T.1    Pedersen, S.S.2    Espersen, F.3    Schiøler, H.4
  • 52
    • 0030340458 scopus 로고    scopus 로고
    • Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
    • Johansen, H.K. (1996) Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals. APMIS, 104 (Suppl 63), 5-42.
    • (1996) APMIS , vol.104 , Issue.SUPPL 63 , pp. 5-42
    • Johansen, H.K.1
  • 53
    • 0036708198 scopus 로고    scopus 로고
    • Detecting early structural lung damage in cystic fibrosis
    • Tiddens, H.A.W.M. (2002) Detecting early structural lung damage in cystic fibrosis. Pediatr Pulmonol, 34, 228-231.
    • (2002) Pediatr Pulmonol , vol.34 , pp. 228-231
    • Tiddens, H.A.W.M.1
  • 55
    • 0017352927 scopus 로고
    • Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey
    • Høiby, N. (1977) Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey. Acta Pathol Microbiol Scand Suppl, 262(C), 3-96.
    • (1977) Acta Pathol Microbiol Scand Suppl , vol.262 , Issue.C , pp. 3-96
    • Høiby, N.1
  • 57
    • 2642572004 scopus 로고    scopus 로고
    • Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
    • Haussler, S. (2004) Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa. Environ Microbiol, 6, 546-551.
    • (2004) Environ Microbiol , vol.6 , pp. 546-551
    • Haussler, S.1
  • 58
    • 0032474853 scopus 로고    scopus 로고
    • Adaptive radiation in a heterogenous environment
    • Rainey, P.B. and Travisano, M. (1998) Adaptive radiation in a heterogenous environment. Nature, 394, 69-72.
    • (1998) Nature , vol.394 , pp. 69-72
    • Rainey, P.B.1    Travisano, M.2
  • 59
    • 0036855625 scopus 로고    scopus 로고
    • Static growth of mucoid Pseudomonas aeruginosa selects for non-mucoid variants that have acquired flagellum-dependent motility
    • Wyckoff, T.J.O., Thomas, B., Hassett, D.J. and Wozniak, D.J. (2002) Static growth of mucoid Pseudomonas aeruginosa selects for non-mucoid variants that have acquired flagellum-dependent motility. Microbiology, 148, 3423-3430.
    • (2002) Microbiology , vol.148 , pp. 3423-3430
    • Wyckoff, T.J.O.1    Thomas, B.2    Hassett, D.J.3    Wozniak, D.J.4
  • 61
    • 0033764648 scopus 로고    scopus 로고
    • The causes of Pseudomonas diversity
    • Spiers, A.J., Buckling, A. and Rainey, P.B. (2000) The causes of Pseudomonas diversity. Microbiology, 146, 2345-2350.
    • (2000) Microbiology , vol.146 , pp. 2345-2350
    • Spiers, A.J.1    Buckling, A.2    Rainey, P.B.3
  • 62
    • 26944464962 scopus 로고    scopus 로고
    • Heterogeneity of biofilms formed by non-mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Lee, B., Haagensen, J.A.J., Ciofu, O., Andersen, J.B., Høiby, N. and Molin, S. (2005) Heterogeneity of biofilms formed by non-mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. J Clin Microbiol, 43, 5247-5255.
    • (2005) J Clin Microbiol , vol.43 , pp. 5247-5255
    • Lee, B.1    Haagensen, J.A.J.2    Ciofu, O.3    Andersen, J.B.4    Høiby, N.5    Molin, S.6
  • 63
    • 0026541092 scopus 로고
    • Role of alginate in infection with mucoid Pseudomonas aeruginosa in cystic fibrosis
    • Pedersen, S.S., Høiby, N., Espersen, F. and Koch, C. (1992) Role of alginate in infection with mucoid Pseudomonas aeruginosa in cystic fibrosis. Thorax, 47, 6-13.
    • (1992) Thorax , vol.47 , pp. 6-13
    • Pedersen, S.S.1    Høiby, N.2    Espersen, F.3    Koch, C.4
  • 65
    • 0029093124 scopus 로고
    • Two years experience with recombinant human DNase I in the treatment of pulmonary disease in cystic fibrosis
    • Shah, P.L., Scott, S.F., Geddes, D.M. and Hodson, ME. (1995) Two years experience with recombinant human DNase I in the treatment of pulmonary disease in cystic fibrosis. Respir Med, 89, 499-502.
    • (1995) Respir Med , vol.89 , pp. 499-502
    • Shah, P.L.1    Scott, S.F.2    Geddes, D.M.3    Hodson, M.E.4
  • 66
    • 0029099327 scopus 로고
    • DNA concentration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase
    • Brandt, T., Breitenstein, S., Vonderhardt, H. and Tummler, B. (1995) DNA concentration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase. Thorax, 50, 880-882.
    • (1995) Thorax , vol.50 , pp. 880-882
    • Brandt, T.1    Breitenstein, S.2    Vonderhardt, H.3    Tummler, B.4
  • 67
    • 0032949273 scopus 로고    scopus 로고
    • Comparison of the in vitro and in vivo response to inhaled DNase in patients with cystic fibrosis
    • Ratjen, F. and Tummler, B. (1999) Comparison of the in vitro and in vivo response to inhaled DNase in patients with cystic fibrosis. Thorax, 54, 91.
    • (1999) Thorax , vol.54 , pp. 91
    • Ratjen, F.1    Tummler, B.2
  • 68
    • 0026638418 scopus 로고
    • Establishment of aging biofilms: possible mechanism of bacterial resistance to antimicrobial therapy
    • Anwar, H., Strap, J.L. and Costerton, J.W. (1992) Establishment of aging biofilms: possible mechanism of bacterial resistance to antimicrobial therapy. Antimicrob Agents Chemother, 36, 1347-1351.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1347-1351
    • Anwar, H.1    Strap, J.L.2    Costerton, J.W.3
  • 69
    • 0026682935 scopus 로고
    • Dynamic interactions of biofilms of mucoid Pseudomonas aeruginosa with tobramycin and piperacillin
    • Anwar, H., Strap, J.L., Chen, K. and Costerton, J.W. (1992) Dynamic interactions of biofilms of mucoid Pseudomonas aeruginosa with tobramycin and piperacillin. Antimicrob Agents Chemother, 36, 1208-1214.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1208-1214
    • Anwar, H.1    Strap, J.L.2    Chen, K.3    Costerton, J.W.4
  • 70
    • 0037541096 scopus 로고    scopus 로고
    • Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration -lack of association in cystic fibrosis
    • Smith, A.L., Fiel, S.B.,MayerHamblett, N., Ramsey, B. and Burns, J.L. (2003) Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration -lack of association in cystic fibrosis. Chest, 123, 1495-1502.
    • (2003) Chest , vol.123 , pp. 1495-1502
    • Smith, A.L.1    Fiel, S.B.2    MayerHamblett, N.3    Ramsey, B.4    Burns, J.L.5
  • 73
    • 2442526705 scopus 로고    scopus 로고
    • Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis
    • Moskowitz, S.M., Foster, J.M., Emerson, J. and Burns, J.L. (2004) Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis. J Clin Microbiol, 42, 1915-1922.
    • (2004) J Clin Microbiol , vol.42 , pp. 1915-1922
    • Moskowitz, S.M.1    Foster, J.M.2    Emerson, J.3    Burns, J.L.4
  • 74
    • 33845938063 scopus 로고    scopus 로고
    • Differentiation and distribution of colistin-and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms
    • Haagensen, J., Klausen, M., Ernst, R.K., Miller, S.I., Folkesson, A., Tolker-Nielsen, T. and Molin, S. (2007) Differentiation and distribution of colistin-and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms. J Bacteriol, 189, 28-37.
    • (2007) J Bacteriol , vol.189 , pp. 28-37
    • Haagensen, J.1    Klausen, M.2    Ernst, R.K.3    Miller, S.I.4    Folkesson, A.5    Tolker-Nielsen, T.6    Molin, S.7
  • 75
    • 0034807455 scopus 로고    scopus 로고
    • Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, b-lactamase activity and RiboPrinting
    • Ciofu, O., Fussing, V., Bagge, N., Koch, C. and Hoiby, N. (2001) Characterization of paired mucoid/non-mucoid Pseudomonas aeruginosa isolates from Danish cystic fibrosis patients: antibiotic resistance, b-lactamase activity and RiboPrinting. J Antimicrob Chemother, 48, 391-396.
    • (2001) J Antimicrob Chemother , vol.48 , pp. 391-396
    • Ciofu, O.1    Fussing, V.2    Bagge, N.3    Koch, C.4    Hoiby, N.5
  • 76
    • 0025061590 scopus 로고
    • Rapid emergence of resistance in Pseudomonas aeruginosa in cystic fibrosis patients due to in vivo selection of stable partially derepressed b-lactamase producing strains
    • Giwercman, B., Lambert, P.A., Rosdahl, V.T., Shand, G.H. and Høiby, N. (1990) Rapid emergence of resistance in Pseudomonas aeruginosa in cystic fibrosis patients due to in vivo selection of stable partially derepressed b-lactamase producing strains. J Antimicrob Chemother, 26, 247-259.
    • (1990) J Antimicrob Chemother , vol.26 , pp. 247-259
    • Giwercman, B.1    Lambert, P.A.2    Rosdahl, V.T.3    Shand, G.H.4    Høiby, N.5
  • 77
    • 0026501586 scopus 로고
    • High-level b-lactamase activity in sputum samples from cystic fibrosis patients during antipseudomonal treatment
    • Giwercman, B., Meyer, C., Lambert, P.A., Reinert, C. and Høiby,N. (1992)High-level b-lactamase activity in sputum samples from cystic fibrosis patients during antipseudomonal treatment. Antimicrob Agents Chemother, 36, 71-76.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 71-76
    • Giwercman, B.1    Meyer, C.2    Lambert, P.A.3    Reinert, C.4    Høiby, N.5
  • 78
    • 0029849055 scopus 로고    scopus 로고
    • Mathematical model of b-lactam penetration into a biofilm of Pseudomonas aeruginosa while undergoing simultaneous inactivation by released b-lactamases
    • Dibdin, G.H., Assinder, S.J., Nichols,W.W. and Lambert, P.A. (1996) Mathematical model of b-lactam penetration into a biofilm of Pseudomonas aeruginosa while undergoing simultaneous inactivation by released b-lactamases. J Antimicrob Chemother, 38, 757-769.
    • (1996) J Antimicrob Chemother , vol.38 , pp. 757-769
    • Dibdin, G.H.1    Assinder, S.J.2    Nichols, W.W.3    Lambert, P.A.4
  • 79
    • 0029796771 scopus 로고    scopus 로고
    • Spread of b-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis unit
    • Denton, M., Littlewood, J.M., Brownlee, K.G., Conway, S.P. and Todd, N.J. (1996) Spread of b-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis unit. Lancet, 348, 1596-1597.
    • (1996) Lancet , vol.348 , pp. 1596-1597
    • Denton, M.1    Littlewood, J.M.2    Brownlee, K.G.3    Conway, S.P.4    Todd, N.J.5
  • 80
    • 0036841078 scopus 로고    scopus 로고
    • Constitutive high expression of chromosomal b-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD
    • Bagge, N., Ciofu, O., Hentzer, M., Campbell, J.I.A.,Givskov,M. and Høiby,N. (2002) Constitutive high expression of chromosomal b-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD. Antimicrob Agents Chemother, 46, 3406-3411.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3406-3411
    • Bagge, N.1    Ciofu, O.2    Hentzer, M.3    Campbell, J.I.A.4    Givskov, M.5    Høiby, N.6
  • 81
    • 0033999155 scopus 로고    scopus 로고
    • Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    • Jalal, S., Ciofu, O., Høiby, N., Gotoh, N. and Wretlind, B. (2000) Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother, 44, 710-712.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 710-712
    • Jalal, S.1    Ciofu, O.2    Høiby, N.3    Gotoh, N.4    Wretlind, B.5
  • 82
    • 0029808250 scopus 로고    scopus 로고
    • Antibiotic susceptibility of multiply resistant Pseudomonas aeruginosa isolated from patients with cystic fibrosis, including candidates for transplantation
    • Saiman, L., Mehar, F., Niu, W.W., Neu, H.C., Shaw, K.J., Miller, G. and Prince, A. (1996) Antibiotic susceptibility of multiply resistant Pseudomonas aeruginosa isolated from patients with cystic fibrosis, including candidates for transplantation. Clin Infect Dis, 23, 532-537.
    • (1996) Clin Infect Dis , vol.23 , pp. 532-537
    • Saiman, L.1    Mehar, F.2    Niu, W.W.3    Neu, H.C.4    Shaw, K.J.5    Miller, G.6    Prince, A.7
  • 85
    • 0034031728 scopus 로고    scopus 로고
    • Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment
    • MacLeod, D.L., Nelson, L.E., Shawar, R.M., Lin, B.B., Lockwood, L.G., Dirks, J.E., Miller, G.H., Burns, J.L. and Garber, R.L. (2000) Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment. J Infect Dis, 181, 1180-1184.
    • (2000) J Infect Dis , vol.181 , pp. 1180-1184
    • MacLeod, D.L.1    Nelson, L.E.2    Shawar, R.M.3    Lin, B.B.4    Lockwood, L.G.5    Dirks, J.E.6    Miller, G.H.7    Burns, J.L.8    Garber, R.L.9
  • 86
    • 0036785981 scopus 로고    scopus 로고
    • Transmission of Colistin-resistant Pseudomonas aeruginosa between patients attending a pediatric cystic fibrosis center
    • Denton, M., Kerr, K., Mooney, L., Keer, V., Raijgoppaal, A., Browniee, K., Arundel, P. and Conway, S. (2002) Transmission of Colistin-resistant Pseudomonas aeruginosa between patients attending a pediatric cystic fibrosis center. Pediatr Pulmonol, 34, 257-261.
    • (2002) Pediatr Pulmonol , vol.34 , pp. 257-261
    • Denton, M.1    Kerr, K.2    Mooney, L.3    Keer, V.4    Raijgoppaal, A.5    Browniee, K.6    Arundel, P.7    Conway, S.8
  • 87
    • 0346655236 scopus 로고    scopus 로고
    • PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A
    • Moskowitz, S.M., Ernst, R.K. and Miller, S.I. (2004) PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol, 186, 575-579.
    • (2004) J Bacteriol , vol.186 , pp. 575-579
    • Moskowitz, S.M.1    Ernst, R.K.2    Miller, S.I.3
  • 88
  • 89
    • 1642543160 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and b-lactamase and alginate production
    • Bagge, N., Schuster, M., Hentzer, M., Ciofu, O., Givskov, M., Greenberg, E.P. and Høiby, N. (2004) Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and b-lactamase and alginate production. Antimicrob Agents Chemother, 48, 1175-1187.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1175-1187
    • Bagge, N.1    Schuster, M.2    Hentzer, M.3    Ciofu, O.4    Givskov, M.5    Greenberg, E.P.6    Høiby, N.7
  • 90
    • 0034685940 scopus 로고    scopus 로고
    • High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
    • Oliver, A.,Canton, R., Campo, P., Baquero, F. and Blazquez, J. (2000) High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science, 288, 1251-1253.
    • (2000) Science , vol.288 , pp. 1251-1253
    • Oliver, A.1    Canton, R.2    Campo, P.3    Baquero, F.4    Blazquez, J.5
  • 91
    • 0036274037 scopus 로고    scopus 로고
    • The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants
    • Oliver, A., Baquero, F. and Blazquez, J. (2002) The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol Microbiol, 43, 1641-1650.
    • (2002) Mol Microbiol , vol.43 , pp. 1641-1650
    • Oliver, A.1    Baquero, F.2    Blazquez, J.3
  • 92
    • 3042673108 scopus 로고    scopus 로고
    • Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusion
    • Macia, M.D., Borrell, N., Perez, J.L. and Oliver, A. (2004) Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusion. Antimicrob Agents Chemother, 48, 2665-2672.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2665-2672
    • Macia, M.D.1    Borrell, N.2    Perez, J.L.3    Oliver, A.4
  • 93
    • 23044473638 scopus 로고    scopus 로고
    • Hypermutation is a key factor in development of multiple-antimicrobial resistanceinPseudomonasaeruginosastrains causing chronic lung infections
    • Macia, M.D., Blanquer, D., Togores, B., Sauleda, J., Perez, J.L. and Oliver, A. (2005) Hypermutation is a key factor in development of multiple-antimicrobial resistanceinPseudomonasaeruginosastrains causing chronic lung infections. Antimicrob Agents Chemother, 49, 3382-3386.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3382-3386
    • Macia, M.D.1    Blanquer, D.2    Togores, B.3    Sauleda, J.4    Perez, J.L.5    Oliver, A.6
  • 95
    • 0036988924 scopus 로고    scopus 로고
    • Antibodies against b-lactamase can improve ceftazidime treatment of lung infection with b-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection
    • Ciofu, O., Bagge, N. and Høiby, N. (2002) Antibodies against b-lactamase can improve ceftazidime treatment of lung infection with b-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection. APMIS, 110, 881-891.
    • (2002) APMIS , vol.110 , pp. 881-891
    • Ciofu, O.1    Bagge, N.2    Høiby, N.3
  • 96
    • 0347504933 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa chromosomal b-lactamase in patients with cystic fibrosis and chronic lung infection -mechanism of antibiotic resistance and target of the humoral immune response
    • Ciofu, O. (2003) Pseudomonas aeruginosa chromosomal b-lactamase in patients with cystic fibrosis and chronic lung infection -mechanism of antibiotic resistance and target of the humoral immune response. APMIS, 111, 4-47.
    • (2003) APMIS , vol.111 , pp. 4-47
    • Ciofu, O.1
  • 97
    • 40649083637 scopus 로고    scopus 로고
    • In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections
    • Epub.
    • Yang, L., Haagensen, J.A.J., Jelsbak, L., Johansen, H.K., Sternberg, C., Høiby, N. and Molin, S. (2007) In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections. J Bacteriol, Epub.
    • (2007) J Bacteriol
    • Yang, L.1    Haagensen, J.A.J.2    Jelsbak, L.3    Johansen, H.K.4    Sternberg, C.5    Høiby, N.6    Molin, S.7
  • 98
    • 84890577775 scopus 로고    scopus 로고
    • Phenotypic and biofilm forming differences of mucoid and non-mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Lee, B., Ciofu, O., Wu, H., Hoffmann, N., Høiby, N. and Molin, S. (2007) Phenotypic and biofilm forming differences of mucoid and non-mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. J.Clin. Microbiol.
    • (2007) J.Clin. Microbiol.
    • Lee, B.1    Ciofu, O.2    Wu, H.3    Hoffmann, N.4    Høiby, N.5    Molin, S.6


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