Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance

Molecular Immunology

Volumn 47, Issue 7-8, 2010, Pages 1635-1639

  Khrustalev, Vladislav Victorovich ^a  

^a BELARUSIAN STATE MEDICAL UNIVERSITY   (Belarus)

Author keywords

Acrophilicity; Acrophobicity; APOBEC1; APOBEC3; Gp120; HIV1; Linear B cell epitopes; Mutational pressure

Indexed keywords

ARGININE; ASPARTIC ACID; CYTOSINE; EPITOPE; GLUTAMIC ACID; GLYCINE; GLYCOPROTEIN GP 120; GUANINE; PROLINE; RNA DIRECTED DNA POLYMERASE; THREONINE; VIRUS DNA; VIRUS RNA;

ALGORITHM; ARTICLE; B LYMPHOCYTE; CODON; COMPUTER MODEL; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID ANALYSIS; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA EDITING; SITE DIRECTED MUTAGENESIS;

ALGORITHMS; COMPUTATIONAL BIOLOGY; EPITOPES, B-LYMPHOCYTE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; INTERNET; MUTATION; PROBABILITY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77950630474     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.01.006     Document Type: Article

References (11)

1. Berkhout B., de Ronde A. APOBEC3G versus reverse transcriptase in the generation of HIV-1 drug-resistance mutations. AIDS 2004, 18(13):1861-1863.
2. Bishop K.N., Holmes R.K., Sheehy A.M., Malim M.H. APOBEC-mediated editing of viral RNA. Science 2004, 305:645.
3. Gros L., Saparbaev M.K., Laval J. Enzymology of the repair of free radicals-induced DNA damage. Oncogene 2002, 21:8905-8925.
4. Hopp T.P., Woods K.R. A computer program for predicting protein antigenic determinants. Mol. Immunol. 1983, 20(4):483-489.
5. Izumi T., Shirakawa K., Takaori-Kondo A. Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapy. Mini Rev. Med. Chem. 2008, 8:231-238.
6. 2-dGTP by reverse transcriptases and mammalian DNA polymerases. JBC 1997, 272(9):5892-5898.
7. Khrustalev V.V. Can mutational GC-Pressure create new linear B-cell epitopes in Herpes Simplex virus type 1 glycoprotein B?. Immunol. Invest. 2009, 38(7):613-623.
8. Larsen J.E.P., Lund O., Nielsen M. Improved method for predicting linear B-cell epitopes. Immun. Res. 2006, 2:2.
9. Petit V., Guétard D., Renard M., Keriel A., Sitbon M., Wain-Hobson S., Vartanian J.P. Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo. J. Mol. Biol. 2009, 385:65-78.
10. Pillai S.K., Wong J.K., Barbour J.D. Turning up the volume on mutational pressure: is more of a good thing always better? (a case study of HIV-1 vif and APOBEC3). Retrovirology 2008, 5:N26.
11. Sueoka N. Directional mutation pressure and neutral molecular evolution. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:2653-2657.