Can mutational gc-pressure create new linear B-cell epitopes in herpes simplex virus type 1 glycoprotein B

Immunological Investigations

Volumn 38, Issue 7, 2009, Pages 613-623

  Khrustalev, Vladislav Victorovich ^a  

^a BELARUSIAN STATE MEDICAL UNIVERSITY   (Belarus)

Author keywords

Acrophilicity; Acrophobicity; GC content; Glycoprotein B; HSV1; Linear B cell epitopes; Mutational pressure

Indexed keywords

EPITOPE; GLYCOPROTEIN B; ISOLEUCINE; METHIONINE; PHENYLALANINE; PROLINE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; B LYMPHOCYTE; CODON; DNA BASE COMPOSITION; HERPES SIMPLEX VIRUS 1; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; BASE COMPOSITION; CODON; COMPUTATIONAL BIOLOGY; EPITOPES; EPITOPES, B-LYMPHOCYTE; HUMANS; MUTATION; VIRAL ENVELOPE PROTEINS;

EID: 71049140106     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130903062202     Document Type: Article

References (10)

1. Eberle, R., Courtney, R. J. (1989). Topological distribution of virus-specific and cross-reactive antigenic determinants on the gB glycoprotein of the herpes simplex viruses. J. Med. Virol. 27(4):309-316.
2. Hopp, T. P. (1984). Protein antigen conformation: Folding patterns and predictive algorithms; selection of antigenic and immunogenic peptides. Ann. Sclavo. 2: 47-60.
3. Hopp, T. P., Woods, K. R. (1983). A computer program for predicting protein antigenic determinants. Mol. Immunol. 20(4):483-489.
4. Khrustalev, V. V., Barkovsky, E. V. (2008). An in-silico study of alphaherpesviruses ICP0 genes: Positive selection or strong mutational GC-pressure? IUBMB Life 60(7): 456-460.
5. Khrustalev, V. V., Barkovsky, E. V. (2008). Mutational pressure in genomes of human a-herpesviruses. Mol. Gen. Microb. Virol. 23(2): 84-100.
6. Kuhn, J. E., Dunkler, G., Munk, K., Braun, R. W. (1987). Analysis of the IgM and IgG antibody response against herpes simplex virus type 1 (HSV-1) structural and nonstructural proteins. J. Med. Virol. 23(2):135-150.
7. Larsen, J. E. P., Lund, O., Nielsen, M. (2006). Improved method for predicting linear Bcell epitopes. Immunome Res. 2: 2.
8. Rubanik, L. V., Kapitulets, N. N., Êîstyuk, S. À., Barkovsky, E. V. and Poleshchuk, N. N. (2008). Induction of antibody response in mice by different way of introduction of inactivated Chlamydia trachomatis MT-2A strain with polyoxidonium combination. Sixth Mit. Europ. Soc. For Chlamydia Res., Aarhus, Denmark, 2008:82.
9. Singer, G. A. C., Hickey, D. A. (2000). Nucleotide bias causes a genomewide bias in the amino acid composition of proteins. Mol. Biol. Evol. 17:1581-1588.
10. Sueoka, N. (1988). Directional mutation pressure and neutral molecular evolution. Proc. Natl. Acad. Sci. USA 85:2653-2657.