α-Actinin 1 and α-actinin 4: Contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells

Experimental Cell Research

Volumn 316, Issue 7, 2010, Pages 1137-1147

  Quick, Quincy ^a   Skalli, Omar ^b  

^a GRAMBLING STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Actin; Cytoskeleton; Glioma

Indexed keywords

ACTIN; ALPHA ACTININ 1; ALPHA ACTININ 4; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; ASTROCYTOMA; ASTROCYTOMA CELL; BIOCHEMISTRY; BRAIN TISSUE; CANCER GRADING; CANCER GROWTH; CARCINOGENESIS; CELL ADHESION; CELL EXPANSION; CELL MOTILITY; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 77950629163     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.02.011     Document Type: Article

References (30)

1. 2+)-binding domain. Eur. J. Biochem. 1992, 210:801-809.
2. Dixson J.D., Forstner M.J., Garcia D.M. The alpha-actinin gene family: a revised classification. J. Mol. Evol. 2003, 56:1-10.
3. Wyszynski M., Kharazia V., Shanghvi R., Rao A., Beggs A.H., Craig A.M., Weinberg R., Sheng M. Differential regional expression and ultrastructural localization of alpha-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain. J. Neurosci. 1998, 18:1383-1392.
4. Honda K., Yamada T., Endo R., Ino Y., Gotoh M., Tsuda H., Yamada Y., Chiba H., Hirohashi S. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J. Cell Biol. 1998, 140:1383-1393.
5. Honda K., Yamada T., Hayashida Y., Idogawa M., Sato S., Hasegawa F., Ino Y., Ono M., Hirohashi S. Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology 2005, 128:51-62.
6. Kikuchi S., Honda K., Tsuda H., Hiraoka N., Imoto I., Kosuge T., Umaki T., Onozato K., Shitashige M., Yamaguchi U., Ono M., Tsuchida A., Aoki T., Inazawa J., Hirohashi S., Yamada T. Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin. Cancer Res. 2008, 14:5348-5356.
7. Yamamoto S., Tsuda H., Honda K., Kita T., Takano M., Tamai S., Inazawa J., Yamada T., Matsubara O. Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod. Pathol. 2007, 20:1278-1285.
8. Barbolina M.V., Adley B.P., Kelly D.L., Fought A.J., Scholtens D.M., Shea L.D., Stack M.S. Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. Lab. Invest. 2008, 88:602-614.
9. Yamamoto S., Tsuda H., Honda K., Onozato K., Takano M., Tamai S., Imoto I., Inazawa J., Yamada T., Matsubara O. Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod. Pathol. 2009, 22:499-507.
10. Craig D.H., Downey C., Basson M.D. SiRNA-mediated reduction of alpha-actinin-1 inhibits pressure-induced murine tumor cell wound implantation and enhances tumor-free survival. Neoplasia 2008, 10:217-222.
11. Edlund M., Lotano M.A., Otey C.A. Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein. Cell Motil. Cytoskelet. 2001, 48:190-200.
12. Jing R., Pizzolato G., Robson R.M., Gabbiani G., Skalli O. Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells. Glia 2005, 50:107-120.
13. Pitre A., Pan Y., Pruett S., Skalli O. On the use of ratio standard curves to accurately quantitate relative changes in protein levels by Western blot. Anal. Biochem. 2007, 361:305-307.
14. Tu Y., Wu S., Shi X., Chen K., Wu C. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 2003, 113:37-47.
15. Pan Y., Jing R., Pitre A., Williams B.J., Skalli O. Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton. FASEB J. 2008, 22:3196-3206.
16. Otey C.A., Carpen O. α-Actinin revisited: a fresh look at an old player. Cell Motil. Cytoskelet. 2004, 58:104-111.
17. Zaoui K., Honoré S., Isnardon D., Braguer D., Badache A. Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J. Cell Biol. 2008, 183:401-408.
18. Glück U., Ben-Ze'ev A. Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells. J. Cell. Sci. 1994, 107:1773-1782.
19. Glück U., Kwiatkowski D.J., Ben-Ze'ev A. Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:383-387.
20. Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.C., Van Meir E.G. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol. 1999, 9:469-479.
21. Badie B., Goh C.S., Klaver J., Herweijer H., Boothman D.A Combined radiation and p53 gene therapy of malignant glioma cells. Cancer Gene Ther. 1999, 6:155-162.
22. He J., Olson J.J., James C.D. Lack of pl6INK4or Retinoblastoma Protein (pRb), or Amplification-associated Overexpression of cdk4 Is Observed in Distinct Subsets of Malignant Glial Tumors and Cell Lines1. Cancer Res. 1995, 55:4833-4836.
23. Wheeler A.P., Ridley A.J. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp. Cell Res. 2004, 301:43-49.
24. Janmey P.A., Hvidt S., Lamb J., Stossel TP Resemblance of actin-binding protein/actin gels to covalently crosslinked networks. Nature 1990, 345:89-92.
25. Ding Z., Liang J., Lu Y., Yu Q., Songyang Z., Lin S.Y., Mills G.B. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:15014-15019.
26. Craig D.H., Haimovich B., Basson M.D. Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction. Am. J. Physiol. Cell Physiol. 2007, 293:C1862-C1874.
27. Zhang Z., Lin S.Y., Neel B.G., Haimovich B. Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase×Src complex and promote cell migration. J. Biol. Chem. 2006, 281:1746-1754.
28. Kos C.H., Le T.C., Sinha S., Henderson J.M., Kim S.H., Sugimoto H., Kalluri R., Gerszten R.E., Pollak M.R. Mice deficient in alpha-actinin-4 have severe glomerular disease. J. Clin. Invest. 2003, 111:1683-1690.
29. Stanley P., Smith A., McDowall A., Nicol A., Zicha D., Hogg N. Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. EMBO J. 2008, 27:62-75.
30. Hara T., Honda K., Shitashige M., Ono M., Matsuyama H., Naito K., Hirohashi S., Yamada T. Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells. Mol. Cell. Proteomics 2007, 6:479-491.