Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol effl ux ability of apolipoprotein A-I Nichinan

Journal of Lipid Research

Volumn 51, Issue 4, 2010, Pages 809-818

  Kono, Momoe ^a   Tanaka, Toshitaka ^a   Tanaka, Masafumi ^a   Vedhachalam, Charulatha ^b   Chetty, Palaniappan S ^b   Nguyen, David ^b   Dhanasekaran, Padmaja ^b   Lund Katz, Sissel ^b   Phillips, Michael C ^b   Saito, Hiroyuki ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

High density lipoprotein; Lipid binding; Natural mutation; Peptide; Tertiary structure

Indexed keywords

ABC TRANSPORTER A1; AMINO ACID; APOLIPOPROTEIN A1; APOLIPOPROTEIN A1 NICHINAN; HIGH DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCA1 PROTEIN, HUMAN; CHOLESTEROL; LIPOSOME; MUTANT PROTEIN; PEPTIDE FRAGMENT; PROTEIN BINDING;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL TRANSPORT; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GENE DELETION; LIPOPROTEIN BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN LIPID INTERACTION; PROTEIN TERTIARY STRUCTURE; PROTEIN VARIANT; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULAR DICHROISM; COMPARATIVE STUDY; GENETICS; HAMSTER; HEAT; HUMAN; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; TIME;

AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEIN A-I; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; CIRCULAR DICHROISM; CRICETINAE; HOT TEMPERATURE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; UNILAMELLAR LIPOSOMES;

EID: 77950610534     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M002113     Document Type: Article

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