Indomethacin sustained release pellets prepared by extrusion-spheronization

Journal of Drug Delivery Science and Technology

Volumn 20, Issue 2, 2010, Pages 119-125

  Mahrous, G M ^a   Ibarhim, M A ^a   El Badry, M ^a   Al Anazi, F K ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Extrusion spheronization; Hydrophilic polymers; Indomethacin; Kinetics; Pellets

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; MACROGOL; MICROCRYSTALLINE CELLULOSE; POLYMER; POVIDONE;

ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PELLET; DRUG RELEASE; FLOW KINETICS; FLOW MEASUREMENT; HYDROPHILICITY; IN VITRO STUDY; MOISTURE; PARTICLE SIZE; PELLET EXTRUSION; QUANTITATIVE ANALYSIS; SPHERONIZATION; SUSTAINED DRUG RELEASE;

EID: 77950600435     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(10)50016-9     Document Type: Article

References (28)

1. Bechgaard H., Nielsen G.H. - Controlled-release multiple-units and single-unit doses. A literature review. - Drug Dev. Ind.. Pharm., 4, 53-67, 1978.
2. Vervaet C., Baert L., Remon J.P. - Extrusion-spheronisation A literature review. - Int. J. Pharm., 116, 131-146, 1995
3. Rainsford K.D., Stetsko P. J., Sirko S.P., Debski S. - Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. - J. Pharm. Pharmacol., 55, 661-668, 2003.
4. Avgerinos A., Malamataris S. - Bioavailability of controlled release indomethacin microspheres and pellets. - Int. J. Pharm., 63, 77-80, 1990.
5. Rowe J.S., Carless J.E. - Comparison of the in vitro dissolution behaviour of various indomethacin formulations with their in vivo bioavailability. - J. Pham Phamarcol., 33, 561-1464, 1981.
6. Chatlapalli R., Rohera B.D. - Study of effect of excipient source variation on rheological behavior of diltiazem HCI-HPMC wet masses using a mixer torque rheometer. -Int. J. Pharm., 238, 139-151, 2002.
7. Luukkonen P., Schæfer T., Podczeck F., Newton M., Hellen L., Yliruusi J. - Characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a powder rheometer. - Eur. J. Pharm. Sci., 13, 143-149, 2001.
8. Soh J.L.P., Liew C.V., Heng P.W.S. -Torque rheological parameters to predict pellet quality in extrusion-spheronization. - Int. J. Pharm., 315, 99-109, 2006.
9. Kristensen J., Schaefer T., Kleinebudde P. - Direct peptization in a rotary processor controlled by torque measurements. I. Influence of process variables. - Pharm Dev Technol., 5, 247-256, 2000.
10. Paul K.E., Fridrun P., Michael N.J. - The rheological properties of modified microcrystalline cellulose containing high levels of model drugs. - J. Pharm. Sci., 98, 2160-2169, 2009.
11. Yaginuma Y., Kijima T. - Effect of pH on rheological properties of microcrystalline cellulose dispersions. - J. Disp. Sci. Technol., 27, 365-370, 2006.
12. Luukkonen P., Schæfer T., Hellén L., Juppo A.M., Yliruusi J. - Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer. - Int. J. Pharm., 188, 181-192, 1999.
13. Chambliss W.G. - In: Pharmaceutical Palletization Technology, Ghebre-Sellassie I. Ed., Marcel Dekker, 1989, pp. 15-38.
14. Robinson R.L., Hollenbeck R.G. - Manufacture of spherical acetaminophen pellets: comparison of rotary processing with multi-step extrusion and spheronization. - Pharm Technol., 15, 48-56, 1991.
15. Parker M.D., Rowe R.C., Upjohn N.G. - Mixer torque rheometry: A method for quantifying the consistency of wet granulations. - Pharm. Tech. Int., 2, 50-64, 1990.
16. Luukkonen P., Schæfer T., Hellén L. Juppo A.M., Yliruusi J. - Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer. - Int. J. Pharm., 188, 181-192, 1999.
17. Ford J.L., Rubinstein M.H. - Phase equilibria and dissolution rate of indomethacin-polyethylene glycol 6000 solid dispersions. - Pharm. Acta Helv., 53, 93-98, 1978.
18. Fini A., Moyano J.R., Gines J.M., Perez-Martinez J.I., Rabasco A.M. - Diclofenac salts. II. Solid dispersions in PEG6000 and Gelucire 50/13. - Eur. J. Pharm. Biopharm., 60, 99-111, 2005.
19. Law M.F.L., Deasy P.B. - Use of canonical and other analyses for the optimization of an extrusion-spheronization process for indomethacin. - Int. J. Pharm., 146, 1-9, 1997.
20. Heng P.W., Wan L.S., Tan Y.T. - Optimization of spheroid production by centrifugal rotary processing. - Int. J. Pharm., 143, 107-112, 1996.
21. Pinto J.F., Buckton G., Newton J.M. - The influence of four selected processing and formulation factors on the production of spheres by extrusion and spheronisation. - Int. J. Pharm., 83, 187-196, 1992.
22. O'Brien M., McCauley J., Cohen E. - Indomethacin. - In: Analytical Profiles of Drug Substances, Florey K. Ed., Academic Press, London, 13, 1984, pp. 211-238.
23. Ahuja N., Katare O. P., Singh B. - Studies on dissolution enhancement and mathematical modelling of drug release of a poorly water-soluble drug using water soluble carriers. - Eur. J. Pharm. Biopharm., 65, 26-38, 2007.
24. Higuchi T. - Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drug dispersed in solid matrices. - J. Pharm. Sci., 52, 1145-1149, 1963.
25. Korsmeyer R.W., Peppas N.A. - Macromolecular and modeling aspects of swelling-controlled systems. - In: Controlled Release Delivery Systems, Roseman T.J., Mansdorf S.Z. Eds., Dekker, New York, 1983, pp. 77-101.
26. Ritger P.L., Peppas N.A. - A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. - J. Control. Release, 5, 37-42, 1987.
27. Mehata A.K., Kislalioglu M.S., Phuapardit W., Malick A. W., Shah N.H. - Release performance of a poorly soluble drug from a novel Eudragit-based multi-unit erosion matrix. - Int. J. Pharm., 213, 7-12, 2001.
28. Ahmed I., Roni M.A., Kibria G., Islam M.R., Jalil R. - In vitro release kinetics study of ambroxol hydrochloride pellets developed by extrusion spheronization technique followed by acrylic polymer coating. - J. Pharm. Sci., 7, 75-81, 2008.