Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model

Arthritis and Rheumatism

Volumn 62, Issue 4, 2010, Pages 1108-1118

  Salisbury Palomares, Kristy T ^a   Gerstenfeld, Louis C ^a   Wigner, Nathan A ^a   Lenburg, Marc E ^a   Einhorn, Thomas A ^a   Morgan, Elise F ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE DEVELOPMENT; CELL ADHESION; CHEMICAL ANALYSIS; CHONDROGENESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMUR OSTEOTOMY; FRACTURE HEALING; GENE EXPRESSION; IN VIVO STUDY; MALE; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; STIMULATION; TISSUE DIFFERENTIATION; UPREGULATION;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROGENESIS; FEMUR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MODELS, ANIMAL; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOTOMY; POSTURE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 77950546712     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27343     Document Type: Article

References (51)

1. Asik M, Ciftci F, Sen C, Erdil M, Atalar A. The microfracture technique for the treatment of full-thickness articular cartilage lesions of the knee: midterm results. Arthroscopy 2008;24:1214-1220
2. Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, et al. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy 2005;21:1066-1075
3. Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, et al. A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am 2007;89:2105-2112
4. Kreuz PC, Erggelet C, Steinwachs MR, Krause SJ, Lahm A, Niemeyer P, et al. Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger? Arthroscopy 2006;22:1180-1186
5. Revell CM, Athanasiou KA. Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects. Tissue Eng Part B Rev 2009;15:1-15.
6. Dowthwaite GP, Edwards JC, Pitsillides AA. An essential role for the interaction between hyaluronan and hyaluronan binding proteins during joint development. J Histochem Cytochem 1998;46:641-651
7. Bland YS, Ashhurst DE. Development and ageing of the articular cartilage of the rabbit knee joint: distribution of the fibrillar collagens. Anat Embryol (Berl) 1996;194:607-619
8. Morrison EH, Ferguson MW, Bayliss MT, Archer CW. The development of articular cartilage: I. The spatial and temporal patterns of collagen types. J Anat 1996;189( Pt 1):9-22.
9. Gepstein A, Shapiro S, Arbel G, Lahat N, Livne E. Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging. Arthritis Rheum 2002;46:3240-3250
10. Kavanagh E, Ashhurst DE. Development and aging of the articular cartilage of the rabbit knee joint: distribution of biglycan, decorin, and matrilin-1. J Histochem Cytochem 1999;47:1603-1616
11. Murphy JM, Heinegard R, McIntosh A, Sterchi D, Barry FP. Distribution of cartilage molecules in the developing mouse joint. Matrix Biol 1999;18:487-497
12. Archer CW, Dowthwaite GP, Francis-West P. Development of synovial joints. Birth Defects Res C Embryo Today 2003;69:144-155
13. Mikic B, Isenstein AL, Chhabra A. Mechanical modulation of cartilage structure and function during embryogenesis in the chick. Ann Biomed Eng 2004;32:18-25.
14. Osborne AC, Lamb KJ, Lewthwaite JC, Dowthwaite GP, Pitsillides AA. Short-term rigid and flaccid paralyses diminish growth of embryonic chick limbs and abrogate joint cavity formation but differentially preserve pre-cavitated joints. J Musculoskelet Neuronal Interact 2002;2:448-456
15. Fell HB, Canti RG. Experiments on the development in vitro of the avian knee joint. Proc R Soc Lond 1934;B116:316-351
16. Drachman DB, Sokoloff L. The role of movement in embryonic joint development. Dev Biol 1966;14:401-420
17. Vanwanseele B, Lucchinetti E, Stussi E. The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions. Osteoarthritis Cartilage 2002;10:408-419
18. Dowthwaite GP, Ward AC, Flannely J, Suswillo RF, Flannery CR, Archer CW, et al. The effect of mechanical strain on hyaluronan metabolism in embryonic fibrocartilage cells. Matrix Biol 1999;18:523-532
19. Smith RL, Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, et al. In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. J Orthop Res 1996;14:53-60.
20. Quinn TM, Grodzinsky AJ, Buschmann MD, Kim YJ, Hunziker EB. Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants. J Cell Sci 1998;111(Pt 5):573-583
21. Takahashi I, Nuckolls GH, Takahashi K, Tanaka O, Semba I, Dashner R, et al. Compressive force promotes Sox9, type II collagen and aggrecan and inhibits IL-1β expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells. J Cell Sci 1998;111(Pt 14):2067-2076
22. Mauck RL, Byers BA, Yuan X, Tuan RS. Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol 2007;6:113-125
23. Angele P, Schumann D, Angele M, Kinner B, Englert C, Hente R, et al. Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds. Biorheology 2004;41:335-346
24. Le AX, Miclau T, Hu D, Helms JA. Molecular aspects of healing in stabilized and non-stabilized fractures. J Orthop Res 2001;19:78-84.
25. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg Br 1985;67:650-655
26. Cullinane DM, Salisbury KT, Alkhiary Y, Eisenberg S, Gerstenfeld L, Einhorn TA. Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development? J Exp Biol 2003;206(Pt 14):2459-2471
27. Claes L, Eckert-Hubner K, Augat P. The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 2002;20:1099-1105
28. Epari DR, Schell H, Bail HJ, Duda GN. Instability prolongs the chondral phase during bone healing in sheep. Bone 2006;38:864-870
29. Salisbury Palomares KT, Gleason RE, Mason ZD, Cullinane DM, Einhorn TA, Gerstenfeld LC, et al. Mechanical stimulation alters tissue differentiation and molecular expression during bone healing. J Orthop Res 2009;27:1123-1132
30. Ferguson C, Alpern E, Miclau T, Helms JA. Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 1999;87:57-66.
31. Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 2003;88:873-884
32. Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, et al. Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One 2009;4:e5393.
33. 't Hoen PA, de Kort F, van Ommen GJ, den Dunnen JT. Fluorescent labelling of cRNA for microarray applications. Nucleic Acids Res 2003;31:e20.
34. Kerr MK, Churchill GA. Experimental design for gene expression microarrays. Biostatistics 2001;2:183-201.
35. Yang YH, Dudoit S, Luu P, Speed TP. Normalization for cDNA microarray data. In: Bittner ML, Chen Y, Dorsel AN, editors. SPIE BiOS; 2001 Jan 21; San Jose, CA. Bellingham (WA): SPIE.
36. Kerr MK, Martin M, Churchill GA. Analysis of variance for gene expression microarray data. J Comput Biol 2000;7:819-837
37. Nakata K, Ono K, Miyazaki J, Olsen BR, Muragaki Y, Adachi E, et al. Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing α1(IX) collagen chains with a central deletion. Proc Natl Acad Sci U S A 1993;90:2870-2874
38. Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL, Sah RL. Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum 2007;56:882-891
39. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-1534
40. Scott IC, Blitz IL, Pappano WN, Imamura Y, Clark TG, Steiglitz BM, et al. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. Dev Biol 1999;213:283-300.
41. Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res 2003;21:872-880
42. Wong M, Ponticiello M, Kovanen V, Jurvelin JS. Volumetric changes of articular cartilage during stress relaxation in unconfined compression. J Biomech 2000;33:1049-1054
43. Bak B, Andreassen TT. The effect of aging on fracture healing in the rat. Calcif Tissue Int 1989;45:292-297
44. Kou I, Ikegawa S. SOX9-dependent and-independent transcriptional regulation of human cartilage link protein. J Biol Chem 2004;279:50942-50948
45. Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, et al. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem 2000;275:10738-10744
46. Zhang P, Jimenez SA, Stokes DG. Regulation of human COL9A1 gene expression: activation of the proximal promoter region by SOX9. J Biol Chem 2003;278:117-123
47. Stokes DG, Liu G, Coimbra IB, Piera-Velazquez S, Crowl RM, Jimenez SA. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum 2002;46:404-419
48. Matsusaki T, Aoyama T, Nishijo K, Okamoto T, Nakayama T, Nakamura T, et al. Expression of the cadherin-11 gene is a discriminative factor between articular and growth plate chondrocytes. Osteoarthritis Cartilage 2006;14:353-366
49. Grogan SP, Barbero A, Diaz-Romero J, Cleton-Jansen AM, Soeder S, Whiteside R, et al. Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum 2007;56:586-595
50. Ochi K, Daigo Y, Katagiri T, Saito-Hisaminato A, Tsunoda T, Toyama Y, et al. Expression profiles of two types of human knee-joint cartilage. J Hum Genet 2003;48:177-182
51. Sampson HW, Dearman AC, Akintola AD, Zimmer WE, Parrish AR. Immunohistochemical localization of cadherin and catenin adhesion molecules in the murine growth plate. J Histochem Cytochem 2007;55:845-852