Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 13, 2010, Pages 6022-6027

  Stankewich, Michael C ^a   Gwynn, Babette ^b   Ardito, Thomas ^a   Ji, Lan ^a   Kim, Jung ^a   Robledo, Raymond F ^b   Lux, Samuel E ^c   Peters, Luanne L ^b   Morrow, Jon S ^a,d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Cytoskeleton; Excitatory amino acid transporter 4; Membrane; Purkinje; Spinocerebellar ataxia type 5

Indexed keywords

BETAIII SPECTRIN; CALPAIN; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 3; EXCITATORY AMINO ACID TRANSPORTER 4; FODRIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR DELTA; NERVE CELL ADHESION MOLECULE; NEUROPEPTIDE Y; PROTEIN; UNCLASSIFIED DRUG; PRIMER DNA; SLC1A6 PROTEIN, MOUSE; SPECTRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM; CONTROLLED STUDY; DENDRITIC SPINE; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE TARGETING; GOLGI COMPLEX; MALE; MOUSE; MYOCLONUS SEIZURE; NERVE CELL DEGENERATION; NERVE CELL LESION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PURKINJE CELL; SOMATIC CELL; SYNAPSE; SYNAPTOGENESIS; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; NERVE DEGENERATION; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; SEIZURE; SPINOCEREBELLAR DEGENERATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALIA; MUS;

ANIMALS; ATAXIA; BASE SEQUENCE; BRAIN; DISEASE MODELS, ANIMAL; DNA PRIMERS; EXCITATORY AMINO ACID TRANSPORTER 4; FEMALE; GENE TARGETING; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE DEGENERATION; PHENOTYPE; SEIZURES; SPECTRIN; SPINOCEREBELLAR ATAXIAS; SYNAPSES;

EID: 77950526211     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001522107     Document Type: Article

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