Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6

Journal of Neurophysiology

Volumn 96, Issue 3, 2006, Pages 1347-1357

  Shirahata, Emi ^a   Iwasaki, Hirohide ^b,c,d   Takagi, Masahiro ^b,c   Lin, Changqing ^a   Bennett, Vann ^e   Okamura, Yasushi ^b,c,d   Hayasaka, Kiyoshi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; COMPLEMENTARY DNA; PROTEIN NAV1 6; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA CHAIN; CHANNEL GATING; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; MEMBRANE BINDING; MEMBRANE DEPOLARIZATION; MOUSE; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RANVIER NODE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM CURRENT;

ANKYRINS; CELL LINE; DNA PRIMERS; EVOKED POTENTIALS; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM CHANNELS; SPINAL CORD; TETRODOTOXIN;

EID: 33748525183     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01264.2005     Document Type: Article

References (31)

1. Bennett V. Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm. J Biol Chem 267: 8703-8706, 1992.
2. Bennett V and Baines AJ. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev 81: 1353-1392, 2001.
3. Bennett V and Gilligan DM. The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane. Annu Rev Cell Biol 9: 27-66, 1993.
4. Bouzidi M, Tricaud N, Giraud P, Kordeli E, Caillol G, Deleuze C, Couraud F, and Alcaraz G. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes. J Biol Chem 277: 28996-29004, 2002.
5. Burbidge SA, Dale TJ, Powell AJ, Whitaker WR, Xie XM, Romanos MA, and Clare JJ. Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brain. Brain Res Mol Brain Res 103: 80-90, 2002.
6. Caldwell JH, Schaller KL, Lasher RS, Peles E, and Levinson SR. Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc Natl Acad Sci USA 97: 5616-5620, 2000.
7. Chahine M, Ziane R, Vijayaragavan K, and Okamura Y. Regulation of Na v channels in sensory neurons. Trends Pharmacol Sci 26: 496-502, 2005.
8. 2+ exchanger. Proc Natl Acad Sci USA 101: 8168-8173, 2004.
9. Garrido JJ, Giraud P, Carlier E, Fernandes F, Moussif A, Fache MP, Debanne D, and Dargent B. A targeting motif involved in sodium channel clustering at the axonal initial segment. Science 300: 2091-2094, 2003.
10. Goldin AL. Diversity of mammalian voltage-gated sodium channels. Ann NY Acad Sci 868: 38-50, 1999.
11. Herzog RI, Cummins TR, Ghassemi F, Dib-Hajj SD, and Waxman SG. Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. J Physiol 551: 741-750, 2003.
12. Jenkins SM and Bennett V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol 155: 739-746, 2001.
13. Kay AR, Sugimori M, and Llinas R. Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells. J Neurophysiol 80: 1167-1179, 1998.
14. Kordeli E, Lambert S, and Bennett V. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 270: 2352-2359, 1995.
15. Kunimoto M, Otto E, and Bennett V. A new 440-kD isoform is the major ankyrin in neonatal rat brain. J Cell Biol 115: 1319-1331, 1991.
16. Kuzmenkin A, Jurkat-Rott K, Lehmann-Horn F, and Mitrovic N. Impaired slow inactivation due to a polymorphism and substitutions of Ser-906 in the II-III loop of the human Nav1.4 channel. Pfluegers 447: 71-77, 2003.
17. Lemaillet G, Walker B, and Lambert S. Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. J Biol Chem 278: 27333-27339, 2003.
18. Magistretti J and Alonso A. Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study. J Gen Physiol 114: 491-509, 1999.
19. + channel activity in dendritic processes of mammalian cortical neurones. J Physiol 521: 629-636, 1999.
20. Mohler PJ, Gramolini AO, and Bennett V. The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem 277: 10599-10607, 2002.
21. Mohler PJ, Hoffman JA, Davis JQ, Abdi KM, Kim CR, Jones SK, Davis LH, Roberts KF, and Bennett V. Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. J Biol Chem 279: 25798-25804, 2004a.
22. Mohler PJ, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori SG, and Bennett V. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci USA 101: 17533-17538, 2004b.
23. Patton DE, Isom LL, Catterall WA, and Goldin AL. The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. J Biol Chem 269: 17649-17655, 1994.
24. Raman IM, Sprunger LK, Meisler MH, and Bean BP. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19: 881-891, 1997.
25. Schwarz JR, Reid G, and Bostock H. Action potentials and membrane currents in the human node of Ranvier. Pfluegers 430: 283-292, 1995.
26. Shcherbatko A, Ono F, Mandel G, and Brehm P. Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophys J 77: 1945-1959, 1999.
27. Smith KJ and Hall SM. Factors directly affecting impulse transmission in inflammatory demyelinating disease: recent advances in our understanding. Curr Opin Neurol 14: 289-298, 2001.
28. Smith MR, Smith RD, Plummer NW, Meisler MH, and Goldin AL. Functional analysis of the mouse Scn8a sodium channel. J Neurosci 18: 6093-6102, 1998.
29. Sommer C. Painful neuropathies. Curr Opin Neurol 16: 623-628, 2003.
30. Wallner M, Weigl L, Meera P, and Lotan I. Modulation of the skeletal muscle sodium channel alpha-subunit by the beta 1-subunit. FEBS Lett 336: 535-539, 1993.
31. Zhou D, Lambert S, Malen PL, Carpenter S, Boland LM, and Bennett V. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol 143: 1295-1304, 1998.