Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2836-2848

  Malancona, Savina ^a   Donghi, Monica ^a   Ferrara, Marco ^a   Martin Hernando, Josè I ^a   Pompei, Marco ^a   Pesci, Silvia ^a   Ontoria, Jesus M ^a   Koch, Uwe ^a   Rowley, Michael ^a   Summa, Vincenzo ^a  

^a IRBM   (Italy)

Author keywords

HCV; Non nucleoside inhibitors; NS5B polymerase

Indexed keywords

8 [(1 BENZYLPIPERIDIN 4 YL)AMINO] 2 (3 CHLOROPHENYL) 6,7 DIHYDRO 1H,5H PYRIDO[3,2,1 IJ]QUINAZOLINE 1,3(2H) DIONE; ANTIVIRUS AGENT; ENZYME INHIBITOR; HEPATITIS C VIRUS RNA POLYMERASE NS5B; NONSTRUCTURAL PROTEIN 5B; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ALLOSTERISM; ARTICLE; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITOR COMPLEX; HEPATITIS C VIRUS; NONHUMAN; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANTIVIRAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 77950518509     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.024     Document Type: Article

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