Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas

Biochemical and Biophysical Research Communications

Volumn 394, Issue 3, 2010, Pages 639-645

  Suzuki, Kotaro ^a   Kobayashi, Tomomi ^a   Funatsu, Osamu ^a   Morita, Akinori ^a   Ikekita, Masahiko ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Activin A; ALK4; Neuronal differentiation; Neuroprotective effect; SMAD pathway

Indexed keywords

ACTIVIN A; ACTIVIN RECEPTOR; ACTIVIN RECEPTOR LIKE KINASE 4; DOPAMINE BETA MONOOXYGENASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTIVIN RECEPTORS, TYPE I; ACTIVINS; ADULT; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; HUMANS; MALE; NEUROGENESIS; NEURONS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SMAD PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 77950517650     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.039     Document Type: Article

References (20)

1. Xia Y., and Schneyer A.L. The biology of activin: recent advances in structure, regulation and function. J. Endocrinol. 202 (2009) 1-12
2. Andreasson K., and Worley P.F. Induction of beta-A activin expression by synaptic activity and during neocortical development. Neuroscience 69 (1995) 781-796
3. Cameron V.A., Nishimura E., Mathews L.S., et al. Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis. Endocrinology 134 (1994) 799-808
4. Kupershmidt L., Amit T., Bar-Am O., et al. The neuroprotective effect of activin A and B: implication for neurodegenerative diseases. J. Neurochem. 103 (2007) 962-971
5. Tretter Y.P., Hertel M., Munz B., et al. Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nat. Med. 6 (2000) 812-815
6. Florio P., Gazzolo D., Luisi S., and Petraglia F. Activin A in brain injury. Adv. Clin. Chem. 43 (2007) 117-130
7. Hashimoto M., Kondo S., Sakurai T., et al. Activin/EDF as an inhibitor of neural differentiation. Biochem. Biophys. Res. Commun. 173 (1990) 193-200
8. Verrecchia F., and Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J. Invest. Dermatol. 118 (2002) 211-215
9. Ogihara T., Watada H., Kanno R., et al. P38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells. J. Biol. Chem. 278 (2003) 21693-21700
10. Biedler J.L., Helson L., and Spengler B.A. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res. 33 (1973) 2643-2652
11. Biedler J.L., Roffler-Tarlov S., Schachner M., and Freedman L.S. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38 (1978) 3751-3757
12. Morita A., Zhu J., Suzuki N., et al. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ. 13 (2006) 499-511
13. Tsuchida K., Nakatani M., Hitachi K., et al. Activin signaling as an emerging target for therapeutic interventions. Cell Commun. Signal. 7 (2009) 15
14. Moustakas A., and Heldin C.H. The regulation of TGFbeta signal transduction. Development 136 (2009) 3699-3714
15. Chen W., Woodruff T.K., and Mayo K.E. Activin A-induced HepG2 liver cell apoptosis: involvement of activin receptors and smad proteins. Endocrinology 141 (2000) 1263-1272
16. Satoh M., Sugino H., and Yoshida T. Activin promotes astrocytic differentiation of a multipotent neural stem cell line and an astrocyte progenitor cell line from murine central nervous system. Neurosci. Lett. 284 (2000) 143-146
17. Bao Y.L., Tsuchida K., Liu B., et al. Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways. J. Endocrinol. 184 (2005) 493-504
18. Heldin C.H., and Moustakas A. A new twist in Smad signaling. Dev. Cell 10 (2006) 685-686
19. Dow A.L., Russell D.S., and Duman R.S. Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models. J. Neurosci. 25 (2005) 4908-4916
20. Ageta H., Murayama A., Migishima R., et al. Activin in the brain modulates anxiety-related behavior and adult neurogenesis. PLoS One 3 (2008) e1869