A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers

Dermatologic Surgery

Volumn 36, Issue 4, 2010, Pages 453-460

  Chen, Tim Mo ^a   Tsai, Jui Che ^b   Burnouf, Thierry ^c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c HUMAN PROTEIN PROCESS SCIENCES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN GLUE; POLYPROPYLENE; WOUND HEALING PROMOTING AGENT;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEBRIDEMENT; DRUG EFFICACY; DRUG SAFETY; FEMALE; GEL; HUMAN; IMMOBILIZATION; LEG ULCER; MALE; PRIORITY JOURNAL; SKIN GRAFT; SKIN ULCER; SPLINT; THROMBOCYTE RICH PLASMA; TREATMENT OUTCOME; WOUND DRESSING; WOUND HEALING;

AGED; AGED, 80 AND OVER; CHRONIC DISEASE; FEMALE; FIBRIN TISSUE ADHESIVE; GELS; GRAFT SURVIVAL; HUMANS; LEG ULCER; MALE; MIDDLE AGED; PILOT PROJECTS; PLATELET TRANSFUSION; PLATELET-RICH PLASMA; PROSPECTIVE STUDIES; RECONSTRUCTIVE SURGICAL PROCEDURES; SKIN; SKIN TRANSPLANTATION; WOUND HEALING;

EID: 77950500872     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2010.01480.x     Document Type: Article

References (32)

1. Mazzucco L, Medici D, Serra M, et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004 44 : 1013 1018.
2. Caloprisco G, Borean A. Chronic skin ulcers: a regenerative simulation by topical hemotherapy. Int J Artif Organs 2004 27 : 816 817.
3. Crovetti G, Martinelli G, Issi M, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apheresis Sci 2004 30 : 145 151.
4. Han SK, Kim DW, Jeong SH, et al. Potential use of blood bank platelet concentrates to accelerate wound healing of diabetic ulcers. Ann Plast Surg 2007 59 : 532 537.
5. Anitua E, Andia I, Ardanza B, et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004 91 : 4 15. (Pubitemid 38111215)
6. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998 85 : 638 646.
7. Everts PA, Knape JT, Weibrich G, et al. Platelet-rich plasma and platelet gel: a review. J Extra Corpor Technol 2006 38 : 174 187.
8. Atri SC, Misra J, Bisht D, Misra K. Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers. Surgery 1990 108 : 508 512.
9. Margolis DJ, Kantor J, Santanna J, et al. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001 24 : 483 488. (Pubitemid 32198417)
10. Valbonesi M, Giannini G, Migliori F, et al. The role of autologous fibrin-platelet glue in plastic surgery: a preliminary report. Int J Artif Organs 2002 25 : 334 338.
11. Bolander ME. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med 1992 200 : 165 170.
12. Henderson JL, Cupp CL, Ross EV, et al. The effects of autologous platelet gel on wound healing. Ear Nose Throat J 2003 82 : 598 602.
13. Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg 2006 117 (7 Suppl) : 143S 9S discussion 50S-51S.
14. Smiell JM, Wieman TJ, Steed DL, et al. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen 1999 7 : 335 346.
15. Kantor J, Margolis DJ. Treatment options for diabetic neuropathic foot ulcers: a cost-effectiveness analysis. Dermatol Surg 2001 27 : 347 351. (Pubitemid 32290859)
16. Harrison-Balestra C, Eaglstein WH, Falabela AF, Kirsner RS. Recombinant human platelet-derived growth factor for refractory nondiabetic ulcers: a retrospective series. Dermatol Surg 2002 28 : 755 759 discussion 9-60.
17. Radosevich M, Goubran HA, Burnouf T. Fibrin sealant: scientific rationale, production methods, properties, and current clinical use. Vox Sang 1997 72 : 133 143.
18. Vedung S, Hedlung A. Fibrin glue: its use for skin grafting of contaminated burn wounds in areas difficult to immobilize. J Burn Care Rehabil 1993 14 : 356 358.
19. Saltz R, Dimick A, Harris C, et al. Application of autologous fibrin glue in burn wounds. J Burn Care Rehabil 1989 10 : 504 507.
20. Chen TM, Tsai JC, Burnouf T. Cranioplasty using osteoconductive scaffold and platelet glue. J Trauma 2008 65 : 1321 1327.
21. Stacey MC, Mata SD, Trengove NJ, Mather CA. Randomised double-blind placebo controlled trial of topical autologous platelet lysate in venous ulcer healing. Eur J Vasc Endovasc Surg 2000 20 : 296 301.
22. Senet P, Bon FX, Benbunan M, et al. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J Vasc Surg 2003 38 : 1342 1348.
23. Anonymous. Guide to the preparation, use and quality assurance of blood components 10th ed.
24. Zimmermann R, Jakubietz R, Jakubietz M, et al. Different preparation methods to obtain platelet components as a source of growth factors for local application. Transfusion 2001 41 : 1217 1224.
25. Everts PA, Brown Mahoney C, Hoffmann JJ, et al. Platelet-rich plasma preparation using three devices: implications for platelet activation and platelet growth factor release. Growth Factors 2006 24 : 165 171.
26. Lacoste E, Martineau I, Gagnon G. Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release. J Periodontol 2003 74 : 1498 1507.
27. Leitner GC, Gruber R, Neumuller J, et al. Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems. Vox Sang 2006 91 : 135 139.
28. Weibrich G, Kleis WK, Hafner G, Hitzler WE. Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Craniomaxillofac Surg 2002 30 : 97 102.
29. Okuda K, Kawase T, Momose M, et al. Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol 2003 74 : 849 857.
30. Weibrich G, Kleis WK, Hitzler WE, Hafner G. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: a technical report. Int J Oral Maxillofac Implants 2005 20 : 118 123.
31. Su CY, Kuo YP, Nieh HL, et al. Quantitative assessment of the kinetics of growth factors release from platelet gel. Transfusion 2008 48 : 2414 2420.
32. Burnouf T, Tseng YH, Kuo YP, Su CY. Solvent/ detergent treatment of platelet concentrates enhances the release of growth factors. Transfusion 2008 48 : 1090 1098.