Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-β and modulates the proliferation of periodontally related cells in vitro

Journal of Periodontology

Volumn 74, Issue 6, 2003, Pages 849-857

  Okuda, Kazuhiro ^a   Kawase, Tomoyuki ^a   Momose, Manabu ^a   Murata, Masashi ^a   Saito, Yoshinori ^a   Suzuki, Hironobu ^a   Wolff, Larry F ^b   Yoshie, Hiromasa ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Growth factors; Growth factors, transforming; Osteoblasts; Periodontal ligament anatomy and histology; Plasma, platelet rich; Platelet derived

Indexed keywords

ALKALINE PHOSPHATASE; BROXURIDINE; DNA; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELL ACTIVITY; CELL COUNT; CELL DIVISION; CELL PROLIFERATION; CELL TYPE; CENTRIFUGATION; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; EPITHELIUM; EPITHELIUM CELL; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOGENESIS; OSTEOBLAST; PERIODONTAL LIGAMENT; PERIODONTIUM; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; THROMBOCYTE COUNT; THROMBOCYTE RICH PLASMA; TISSUE REGENERATION; UPREGULATION;

EID: 0037586421     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2003.74.6.849     Document Type: Article

References (34)

1. Lynch SE, Williams RC, Polson AM, et al. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16:545-548.
2. Wang H-L, Pappert TD, Castelli WA, Chiego DJ Jr, Shyr Y, Smith BA. The effect of platelet-derived growth factor on the cellular response of the periodontium: An autoradiographic study on dogs. J Periodontol 1994;65: 429-436.
3. Okuda K, Nakajima Y, Irie K, et al. Transforming growth factor-β1 coated β-tricalcium phosphate pellets stimulate healing of experimental bone defects of rat calvariae. Oral Dis 1995;1:92-97.
4. 1) on wound healing, with or without barrier membranes, in a class II furcation defect in sheep. J Periodont Res 1998;33:335-344.
5. Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res 2001;80:2075-2079.
6. Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). J Periodont Res 1994;29:439-445.
7. Bowers G, Felton F, Middleton C, et al. Histologic comparison of regeneration in human intrabony defects when osteogenin is combined with demineralized freeze-dried bone allograft and with purified bovine collagen. J Periodontol 1991;62:690-702.
8. Giannobile WV, Ryan S, Shih M-S, Su DL, Kaplan PL, Chan TCK. Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects. J Periodontol 1998;69:129-137.
9. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjö UME. Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995; 66:131-138.
10. Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile WV, Lynch SE. A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 1997;68:1186-1193.
11. Zhang L, Leeman E, Carnes DC, Graves DT. Human osteoblasts synthesize and respond to platelet-derived growth factor. Am J Physiol 1991;261:C348-C354.
12. Rydziel S, Ladd C, McCarthy TL, Centrella M, Canalis E. Determination and expression of platelet-derived growth factor-AA in bone cell cultures. Endocrinology 1992;130: 1916-1922.
13. Canalis E, McCarthy TL, Centrella M. Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol 1989;140:530-537.
14. Cochran DL, Rouse CA, Lynch SE, Graves DT. Effects of platelet-derived growth factor isoforms on calcium release from neonatal mouse calvariae. Bone 1993; 14:53-58.
15. Gilardetti RS, Chaibi MS, Stroumza J, et al. High-affinity binding of PDGF-AA and PDGF-BB to normal human osteoblastic cells and modulation by interleukin-1. Am J Physiol 1991;261:C980-C985.
16. Hughes FJ, Aubin JE, Heersche JNM. Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor β. Bone Miner 1992;19: 63-74.
17. Sporn MB, Roberts AB. Transforming growth factor-β: Recent progress and new challenges. J Cell Biol 1992; 119:1017-1021.
18. Okuda K, Murata M, Sugimoto M, et al. TGF-β1 influences early gingival wound healing in rats: an immunohistochemical evaluation of stromal remodelling by extracellular matrix molecules and PCNA. J Oral Pathol Med 1998;27:463-469.
19. Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 1984; 309:804-806.
20. Kawase T, Okuda K, Yoshie H, Burns DM. Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodont Res 2000;35:291-300.
21. Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM. Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodont Res 2001; 36:367-376.
22. Landesberg R, Roy M, Glickman RS. Quantification of growth factor levels using simplified method of platelet-rich plasma gel preparation. J Oral Maxillofac Surg 2000; 58:297-300.
23. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646.
24. Weibrich G, Kleis WKG, Hafner G. Growth factor levels in the platelet-rich plasma produced by 2 different methods: Curasan-type PRP kit versus PCCS PRP system. Int J Oral Maxillofac Implants 2002;17:184-190.
25. Marx RE. Platelet-rich plasma: A source of multiple autologous growth factors for bone grafts. In: Lynch SE, Genco RJ, Marx RE, eds. Tissue Engineering. Applications in Maxillofacial Surgery and Periodontics. Chicago: Quintessence Publishing Co., Inc.; 1999:71-82.
26. Bowen-Pope DF, Vogel A, Ross R. Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents. Proc Natl Acad Sci (USA) 1984;81:2396-2400.
27. Alvares O, Klebe R, Grant G, Cochran DL. Growth factor effects on the expression of collagenase and TIMP-1 in periodontal ligament cells. J Periodontol 1995;66: 552-558.
28. Arnaud E, Morieux C, Wybier M, de Vernejoul MC. Potentiation of transforming growth factor (TGF-β1) by natural coral and fibrin in a rabbit cranioplasty model. Calcif Tissue Int 1994;54:493-498.
29. Piché JE, Graves DT. Study of the growth factor requirements of human bone-derived cells: A comparison with human fibroblasts. Bone 1989;10:131-138.
30. Shipley GD, Pittelkow MR, Wille JJ Jr, Scott RE, Moses HL. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum free medium. Cancer Res 1986;46:2068-2071.
31. Tucker RF, Shipley GD, Moses HL, Holley RW. Growth inhibitor from BSC-1 cells closely related to platelet type β transforming growth factor. Science 1984;226:705-707.
32. WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation. J Periodont Res 2002;37:255-262.
33. Dennison DK, Vallone DR, Pinero GJ, Rittman B, Caffesse RG. Differential effect of TGF-β1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts. J Periodontol 1994;65:641-648.
34. Kawase T, Okuda K, Wolff LF, Yoshie H. Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol 2003;74:858-864.