Reactivity assays - Dealing with substances and samples in an in vitro world - The solution and the real problem

Contact Dermatitis

Volumn 62, Issue 4, 2010, Pages 256-257

  Pease, Camilla ^a   Thain, Emma ^a   Zazzeroni, Raniero ^a  

^a UNILEVER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGRANCE;

ASSAY; CHEMICAL LABELING; CHEMICAL REACTION; IN VITRO STUDY; LETTER; MASS SPECTROMETRY; PRODUCT DEVELOPMENT; PROTEIN DEPLETION; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SKIN SENSITIZATION;

ALLERGENS; CONSUMER PRODUCT SAFETY; DERMATITIS, CONTACT; DRUG CONTAMINATION; HUMANS; MASS SPECTROMETRY; PATCH TESTS; PEPTIDES;

EID: 77950486755     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2010.01704.x     Document Type: Letter

References (4)

1. Gerberick F, Aleksic M, Basketter D et al. Chemical reactivity measurement and the predictive identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64. Altern Lab Anim 2008 : 36 : 215 242.
2. Natsch A, Gfeller H. LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential. Toxicol Sci 2008 : 106 : 464 478.
3. Aleksic M, Thain E, Roger D, Saib O, Davies M, Li J, Aptula A, Zazzeroni R. Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment. Toxicol Sci 2009 : 108 : 401 411.
4. Natsch A, Gfeller H, Emter R, Ellis G. Use of in vitro testing to identify an unexpected skin sensitizing impurity in a commercial product: a case study. Toxicol In Vitro 2009 : October [epub ahead of print]. PMID: 19883749 (Pubmed).