Repression of cAMP-induced expression of the mouse P450 17α- hydroxylase/C17-20 lyase gene (Cyp17) by androgens

Molecular Endocrinology

Volumn 11, Issue 1, 1997, Pages 87-96

  Burgos Trinidad, María ^a,b,d   Youngblood, Geri L ^a,e   Maroto, Medardo R ^a   Scheller, Arno ^a   Robins, Diane M ^a,b   Payne, Anita H ^a,b,c,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CYCLIC AMP; CYTOCHROME P450; DEOXYRIBONUCLEASE I; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; DNA BINDING; DNA FLANKING REGION; DNA FOOTPRINTING; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LEYDIG CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; CYCLIC AMP; CYTOCHROME P-450 ENZYME SYSTEM; DIHYDROTESTOSTERONE; DNA FOOTPRINTING; ENZYME INDUCTION; GENES, REPORTER; HUMANS; LEYDIG CELL TUMOR; LEYDIG CELLS; MALE; MICE; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, ANDROGEN; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; SECOND MESSENGER SYSTEMS; STEROID 17-ALPHA-HYDROXYLASE; TESTICULAR NEOPLASMS; TESTOSTERONE; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; FELIS CATUS;

EID: 0031036101     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.1.87     Document Type: Article

References (46)

1. 17 20 lyase in Leydig cells. Biol Reprod 42:399-404
2. Malaska T, Payne AH 1984 Luteinizing hormone and cyclic AMP-mediated induction of microsomal cytochrome P-450 enzymes in cultured mouse Leydig cells. J Biol Chem 259:11654-11657
3. Anakwe OO, Payne AH 1987 Noncoordinate regulation of de novo synthesis of cytochrome P-450 17α-hydroxylase/C17-20 lyase in mouse Leydig cell cultures: relation to steroid production. Mol Endocrinol 1:595-603
4. 17α by an androgen receptor-mediated mechanism. J Biol Chem 262:11200-11206
5. 17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells. Endocrinology 129:1429-1435
6. 17-20 lyase activities in cultured mouse Leydig cells is enhanced by inhibition of steroid biosynthesis. Endocrinology 118:1222-1228
7. 17-20 lyase. Genomics 10:270-275
8. 17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3′,5′-monophosphate in MA-10 Leydig cells. Mol Endocrinol 6:927-934
9. Payne AH, Youngblood GL 1995 Regulation of expression of steroidogenic enzymes in Leydig cells. Biol Reprod 52:217-225
10. Payne AH, Youngblood GL, Burgos-Trinidad M, Bain PA 1994 Characterization, regulation, and tissue specific expression of steroidogenic enzymes. In: Bartke A (ed) Function of Somatic Cells in the Testis. Springer-Verlag, New York, pp 109-125
11. Quigley CA, Evans BA, Simental JA, Marschke KB, Sar M, Lubahn DB, Davies P, Hughes IA, Wilson EM, French FS 1992 Complete androgen insensitivity due to deletion of exon C of the androgen receptor gene highlights the functional importance of the second zinc finger of the androgen receptor in vivo. Mol Endocrinol 6:1103-1112
12. Kemppainen JA, Lane MV, Sar M, Wilson EM 1992 Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. J Biol Chem 267:968-974
13. Beato M 1989 Gene regulation by steroid hormones. Cell 56:335-344
14. Adler AJ, Scheller A, Hoffman Y, Robins DM 1991 Multiple components of a complex androgen-dependent enhancer. Mol Endocrinol 5:1587-1596
15. Scarlett CO, Robins DM 1995 In vivo footprinting of an androgen-dependent enhancer reveals an accessory element integral to hormonal response. Mol Endocrinol 9:413-423
16. Adler AJ, Scheller A, Robins DM 1993 The stringency and magnitude of androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences. Mol Cell Biol 13:6326-6335
17. Gulizia S, D'Agata R, Sanborn BM, Steinberger E 1983 Evidence for the presence of androgen receptors in purified rat Leydig cells. J Androl 4:248-252
18. Lindzey J, Grossman M, Kumar MV, Tindall DJ 1993 Regulation of the mouse 5′-flanking region of the mouse androgen receptor gene by cAMP and androgen. Mol Endocrinol 7:1530-1540
19. Clay CM, Keri RA, Finicle AB, Heckert LL, Hamernik DL, Marschke KM, Wilson EM, French FS, Nilson JH 1993 Transcriptional repression of the glycoprotein hormone a subunit gene by androgen may involve direct binding of androgen receptor to the proximal promoter. J Biol Chem 268:13556-13564
20. Fuller PJ 1991 The steroid receptor superfamily: mechanisms of diversity. FASEB J 5:3092-3099
21. Levine M, Manley JL 1989 Transcriptional repression of eukaryotic promoters. Cell 59:405-408
22. Sakai DD, Helms S, Carlstedt-Duke J, Gustafsson J-A, Rottman FM, Yamamoto KR 1988 Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev 2:1144-1154
23. Drouin J, Charron J, Gagner J-P, Jeannotte L, Nemer M, Plante RK, Wrange Ö 1987 Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids. J Cell Biochem 35:293-304
24. Cairns C, Cairns W, Okret S 1993 Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/antiprogestin RU486. DNA Cell Biol 12:695-702
25. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL 1988 Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241:350-353
26. Oro AE, Hollenberg SM, Evans RM 1988 Transcriptional inhibition by a glucocorticoid receptor-β-galactosidase fusion protein. Cell 55:1109-1114
27. Adler S, Waterman ML, He X, Rosenfeld MG 1988 Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 52:685-695
28. Krishna V, Chatterjee K, Madison LD, Mayo S, Jameson JL 1991 Repression of the human glycoprotein hormone a subunit by glucocorticoids: evidence for receptor interactions with limiting transcriptional activators. Mol Endocrinol 5:100-110
29. Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P 1990 Antitumor promotion and antiinflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62:1189-1204
30. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M 1990 Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215
31. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR 1990 Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272
32. Montepit ML, Lawlep KR, Tenniswood MP 1986 Androgen-repressed messages in the rat ventral prostate. Prostate 8:25-36
33. Leger JG, Montepit ML 1987 Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate. Biochem Biophys Res Commun 147:196-203
34. Kyprianou N, Isaacs J 1989 Expression of transforming growth factor-beta in the rat ventral prostate during castration-induced programmed cell death. Mol Endocrinol 3:1515-1522
35. Quarmby VE, Yarbrough WG, Lubahn DB, French FS, Wilson EM 1990 Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol 4:22-28
36. Kallio PJ, Poukka H, Moilanen A, Jänne OA, Palvimo JJ 1995 Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element. Mol Endocrinol 9:1017-1028
37. Rennie PS, Bruchovsky N, Leco KJ, Sheppard PC, McQueen SA, Cheng H, Snoek R, Hamel A, Bock ME, MacDonald BS, Nickel, BE, Chang, C, Liao, S, Cattini, PA, Matusik, RJ 1993 Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene. Mol Endocrinol 7:23-26
38. Payne AH, Youngblood GL, Sha L, Burgos-Trinidad M, Hammond SH 1992 Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells. J Steroid Biochem Mol Biol 43:895-906
39. Allgood VE, Oakley RH, Cidlowski JA 1993 Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor. J Biol Chem 268:20870-20876
40. He WW, Fischer LM, Sun S, Bilhartz DL, Zhu X, Young CY-F, Kelley DB, Tindall DJ 1990 Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog. Biochem Biophys Res Commun 171:697-704
41. Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM 1989 Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240:327-330
42. Xie Y-B, Sui Y-P, Shan L-X, Palvimo JJ, Phillips DM, Jänne OA 1992 Expression of androgen receptor in insect cells. Purification of the receptor protein and renaturation of its steroid- and DNA-binding functions. J Biol Chem 267:4939-4948
43. Kallio PJ, Palvimo JJ, Mehto M, Jänne OA 1994 Analysis of androgen receptor-DNA interactions with receptor proteins produced in insect cells. J Biol Chem 269:11514-11522
44. Chen C, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
45. Yarbrough WG, Quarmby VE, Simental JA, Joseph DR, Sar M, Lubahn DB, Olsen KL, Fench FS, Wilson EM 1990 A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem 265:8893-8900
46. Maxam AM, Gilbert W 1980 Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol 65:499-560