The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells

Toxicology and Applied Pharmacology

Volumn 244, Issue 3, 2010, Pages 374-384

  Liu, Qi bing ^a   Liu, Lu lu ^a   Lu, Ying mei ^b   Tao, Rong rong ^a   Huang, Ji yun ^a   Shioda, Norifumi ^b   Moriguchi, Shigeki ^b   Fukunaga, Kohji ^b   Han, Feng ^a   Lou, Yi jia ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Eendothelial cells; Mitochondria; Peroxynitrite, Omi HtrA2; S nitrosoglutathione

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; 5 CARBOXY 2',7' DICHLOROFLUORESCEIN DIACETATE; 6 CARBOXY 2',7' DICHLOROFLUORESCEIN DIACETATE; DEATH RECEPTOR; FLUORESCENT DYE; NITRIC OXIDE; PEROXYNITRITE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; S NITROSOGLUTATHIONE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; AMINE OXIDE; APOCYNIN; CYTOTOXIN; MITOCHONDRIAL PROTEIN; PEROXYNITROUS ACID; PYRIMIDINONE DERIVATIVE; SERINE PROTEINASE; TEMPOL; THIOKETONE; UCF 101;

APOPTOSIS; ARTICLE; CELL LINE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; SPIN LABELING;

ACETOPHENONES; APOPTOSIS; CELL LINE; CELL SURVIVAL; CYCLIC N-OXIDES; CYTOTOXINS; ENDOTHELIAL CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NADPH OXIDASE; NITRIC OXIDE; OXIDATIVE STRESS; PEROXYNITROUS ACID; PYRIMIDINONES; REACTIVE OXYGEN SPECIES; S-NITROSOGLUTATHIONE; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SPIN LABELS; THIONES;

EID: 77950473752     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.02.004     Document Type: Article

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