Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior

Journal of Biological Chemistry

Volumn 285, Issue 6, 2010, Pages 3664-3675

  Mashanov, Gregory I ^a   Nobles, Muriel ^b   Harmer, Stephen C ^b   Molloy, Justin E ^a   Tinker, Andrew ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN CYTOSKELETON; ADENOSINE RECEPTOR; C-TERMINAL REGIONS; CELL TYPES; DIFFUSIVE BEHAVIOR; DIRECT OBSERVATION; DUAL COLOR; G-PROTEIN COUPLED RECEPTORS; HEK293 CELLS; IN-CELL; INDIVIDUAL ION CHANNELS; ION CHANNEL; JASPLAKINOLIDE; LONG QT SYNDROME; LOW LEVEL; MAMMALIAN CELLS; MEAN SQUARED DISPLACEMENT; MICROTUBULES; PLASMA MEMBRANES; POTASSIUM CHANNELS; RED FLUORESCENT PROTEINS; TIME INTERVAL; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; VESICLE TRAFFICKING; WILD TYPES;

CELL MEMBRANES; COMPLEXATION; CYTOLOGY; FLUORESCENCE; FLUORESCENCE MICROSCOPY; IONS; MAMMALS; MOLECULES; REFRACTIVE INDEX;

PROTEINS;

ADENOSINE A1 RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; JASPAMIDE; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 2A; UNCLASSIFIED DRUG; ABC TRANSPORTER; DEPSIPEPTIDE; DRUG RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNE1 PROTEIN, HUMAN; KCNQ1 PROTEIN, HUMAN; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HUMAN; HUMAN CELL; LONG QT SYNDROME; MEMBRANE VESICLE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HEART MUSCLE CELL; KINETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT;

MAMMALIA;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CELL MEMBRANE; DEPSIPEPTIDES; GREEN FLUORESCENT PROTEINS; HUMANS; KCNQ1 POTASSIUM CHANNEL; KINETICS; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MUTATION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 77950468071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.039974     Document Type: Article

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