Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis

PLoS Pathogens

Volumn 6, Issue 3, 2010, Pages

  Gadjeva, Mihaela ^a   Nagashima, Jill ^a   Zaidi, Tanweer ^a   Mitchell, Robert A ^b   Pier, Gerald B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR ALPHA; 4 IODO 6 PHENYLPYRIMIDINE; 4-IODO-6-PHENYLPYRIMIDINE; ISOMERASE; MIF PROTEIN, MOUSE; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CELL INVASION; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE MODEL; EPITHELIUM CELL; IMMUNE RESPONSE; INFECTION RESISTANCE; INFECTION SENSITIVITY; INFLAMMATION; INHIBITION KINETICS; INNATE IMMUNITY; KERATITIS; KNOCKOUT MOUSE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN DEFICIENCY; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; WILD TYPE; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; FEMALE; GENETICS; IMMUNOLOGY; MALE; MICROBIOLOGY; MOUSE MUTANT; PATHOLOGY; PSEUDOMONAS INFECTION;

BACTERIA (MICROORGANISMS); MUS; PSEUDOMONAS AERUGINOSA;

ANIMALS; DISEASE MODELS, ANIMAL; EPITHELIUM, CORNEAL; FEMALE; INTRAMOLECULAR OXIDOREDUCTASES; KERATITIS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PYRIMIDINES; RNA, SMALL INTERFERING;

EID: 77950444852     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000826     Document Type: Article

References (32)

1. Robertson DM, Petroll WM, Jester JV, Cavanagh HD (2007) The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview. Eye Contact Lens 33: 394-398; discussion 399-400.
2. Robertson DM, Petroll WM, Jester JV, Cavanagh HD (2007) Current concepts: contact lens related Pseudomonas keratitis. Cont Lens Anterior Eye 30: 94-107.
3. Fleiszig SM, Evans DJ (2002) The pathogenesis of bacterial keratitis: studies with Pseudomonas aeruginosa. Clin Exp Optom 85: 271-278.
4. Fleiszig SM (2006) The Glenn A. Fry award lecture 2005. The pathogenesis of contact lens-related keratitis. Optom Vis Sci 83: 866-873.
5. O'Brien TP, Maguire MG, Fink NE, Alfonso E, McDonnell P (1995) Efficacy of ofloxacin vs cefazolin and tobramycin in the therapy for bacterial keratitis. Report from the Bacterial Keratitis Study Research Group. Arch Ophthalmol 113: 1257-1265.
6. Calandra T, Roger T (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3: 791-800. (Pubitemid 37328657)
7. Flaster H, Bernhagen J, Calandra T, Bucala R (2007) The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol 21: 1267-1280. (Pubitemid 46984737)
8. Calandra T, Bernhagen J, Metz CN, Spiegel LA, Bacher M, et al. (1995) MIF as a glucocorticoid-induced modulator of cytokine production. Nature 377: 68-71.
9. Bernhagen J, Calandra T, Cerami A, Bucala R (1994) Macrophage migration inhibitory factor is a neuroendocrine mediator of endotoxaemia. Trends Microbiol 2: 198-201. (Pubitemid 24171988)
10. Calandra T, Bucala R (1995) Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock. J Inflamm 47: 39-51. (Pubitemid 26376200)
11. Bozza M, Satoskar AR, Lin G, Lu B, Humbles AA, et al. (1999) Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med 189: 341-346. (Pubitemid 29063255)
12. Assuncao-Miranda I, Amaral FA, Bozza FA, Fagundes CT, Sousa LP, et al. (2009) Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection. FASEB J.
13. Sevketoglu E, Yilmaz A, Gedikbasi A, Karyagar S, Kiyak A, et al. (2009) Urinary macrophage migration inhibitory factor in children with urinary tract infection. Pediatr Nephrol.
14. Hou XQ, Gao YW, Yang ST, Wang CY, Ma ZY, et al. (2009) Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. Acta Virol 53: 225-231.
15. Matsuda A, Tagawa Y, Yoshida K, Matsuda H, Nishihira J (1997) Expression of macrophage migration inhibitory factor in rat retina and its immunohistochemical localization. J Neuroimmunol 77: 85-90. (Pubitemid 27286380)
16. Matsuda A, Tagawa Y, Matsuda H, Nishihira J (1997) Expression of macrophage migration inhibitory factor in corneal wound healing in rats. Invest Ophthalmol Vis Sci 38: 1555-1562. (Pubitemid 27317851)
17. Matsuda A, Tagawa Y, Matsuda H, Nishihira J (1996) Identification and immunohistochemical localization of macrophage migration inhibitory factor in human cornea. FEBS Lett 385: 225-228. (Pubitemid 26167462)
18. Apte RS, Sinha D, Mayhew E, Wistow GJ, Niederkorn JY (1998) Cutting edge: role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege. J Immunol 160: 5693-5696. (Pubitemid 28298023)
19. Hazlett LD (2005) Inflammatory response to Pseudomonas aeruginosa keratitis. Ocul Surf 3: S139-141.
20. Zhang J, Wu XY, Yu FS (2005) Inflammatory responses of corneal epithelial cells to Pseudomonas aeruginosa infection. Curr Eye Res 30: 527-534. (Pubitemid 41113554)
21. Zhu H, Conibear TC, Thuruthyil SJ, Willcox MD (2008) Pseudomonas aeruginosa quorum-sensing signal molecules induce IL-8 production by human corneal epithelial cells. Eye Contact Lens 34: 179-181.
22. Miyazaki D, Inoue Y, Araki-Sasaki K, Shimomura Y, Tano Y, et al. (1998) Neutrophil chemotaxis induced by corneal epithelial cells after herpes simplex virus type 1 infection. Curr Eye Res 17: 687-693. (Pubitemid 28367779)
23. Winner M, Meier J, Zierow S, Rendon BE, Crichlow GV, et al. (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res 68: 7253-7257.
24. Liao H, Bucala R, Mitchell RA (2003) Adhesion-dependent signaling by macrophage migration inhibitory factor (MIF). J Biol Chem 278: 76-81. (Pubitemid 36043546)
25. Lue H, Thiele M, Franz J, Dahl E, Speckgens S, et al. (2007) Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene 26: 5046-5059. (Pubitemid 47206949)
26. Hazlett LD (2002) Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T cells, Langerhans cells, PMN, and cytokines. DNA Cell Biol 21: 383-390.
27. Thakur A, Xue M, Stapleton F, Lloyd AR, Wakefield D, et al. (2002) Balance of pro- and anti-inflammatory cytokines correlates with outcome of acute experimental Pseudomonas aeruginosa keratitis. Infect Immun 70: 2187-2197. (Pubitemid 34242222)
28. Xue ML, Thakur A, Willcox MD, Zhu H, Lloyd AR, et al. (2003) Role and regulation of CXC-chemokines in acute experimental keratitis. Exp Eye Res 76: 221-231. (Pubitemid 36263348)
29. Preston MJ, Fleiszig SM, Zaidi TS, Goldberg JB, Shortridge VD, et al. (1995) Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Infect Immun 63: 3497-3501.
30. Gadjeva M, Wang Y, Horwitz BH (2007) NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol 37: 2509-2517. (Pubitemid 47423620)
31. Zaidi TS, Lyczak J, Preston M, Pier GB (1999) Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Infect Immun 67: 1481-1492. (Pubitemid 29108532)
32. Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, et al. (2008) Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem 80: 4741-4751.