Ultrafast dynamics show that the theophylline and 3-methylxanthine aptamers employ a conformational capture mechanism for binding their ligands

Biochemistry

Volumn 49, Issue 13, 2010, Pages 2943-2951

  Lee, Sang Won ^a   Zhao, Liang ^a   Pardi, Arthur ^b   Xia, Tianbing ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMERS; BASE STACKING; BOUND STATE; CONFORMATIONAL DYNAMICS; CONFORMATIONAL HETEROGENEITY; CONFORMATIONAL STATE; ENERGY LANDSCAPE; FLUORESCENCE DECAYS; INTERNAL LOOPS; LIGAND BINDING; MULTIPLE CONFORMATIONS; NMR STRUCTURES; PICOSECOND DYNAMICS; PICOSECONDS; RNA APTAMER; TIME-RESOLVED FLUORESCENCE; ULTRA-FAST; ULTRA-FAST DYNAMICS;

BINDING ENERGY; COMPLEXATION; FLUORESCENCE; LIGANDS; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; POLYMORPHISM; RNA;

DYNAMICS;

3 METHYLXANTHINE; APTAMER; RNA; THEOPHYLLINE;

ANISOTROPY; ARTICLE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE SPECTROSCOPY; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANISOTROPY; APTAMERS, NUCLEOTIDE; KINETICS; NUCLEIC ACID CONFORMATION; SPECTROMETRY, FLUORESCENCE; THEOPHYLLINE; XANTHINES;

EID: 77950423140     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100106c     Document Type: Article

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