A novel method for quantitative measurement of a therapeutic monoclonal antibody in the presence of its target protein using enzymatic digestion

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 565-570

  Doucet, Julie ^a   Avrameas, Alexandre ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

ELISA; Enzymatic digestion; Monoclonal antibody; Pharmacokinetic; Target interference

Indexed keywords

MONOCLONAL ANTIBODY; PEPSIN A; RECOMBINANT PROTEIN;

ACCURACY; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOASSAY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; WESTERN BLOTTING; ANIMAL; ANTIBODY COMBINING SITE; BLOOD; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG SCREENING; MACACA FASCICULARIS; METABOLISM; PROCEDURES;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MACACA FASCICULARIS; RATS; RECOMBINANT PROTEINS;

EID: 77950369761     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.01.033     Document Type: Article

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