DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9583-9593

  Novakovic, Boris ^a,b   Wong, Nick C ^a   Sibson, Mandy ^a   Ng, Hong Kiat ^a   Morley, Ruth ^a   Manuelpillai, Ursula ^c   Down, Thomas ^d   Rakyan, Vardhman K ^e   Beck, Stephan ^f   Hiendleder, Stefan ^g   Roberts, Claire T ^h   Craig, Jeffrey M ^a,b   Saffery, Richard ^a,b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF ADELAIDE   (Australia)

^h UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLATION; DNA METHYLTRANSFERASES; DNA SEQUENCING; DOWN-REGULATION; EPIGENETIC REGULATION; EPIGENOMES; GENE FAMILIES; HUMAN PLACENTA; HYPERMETHYLATION; HYPOMETHYLATION; IN-VITRO; METHYLTRANSFERASES; PROMOTER METHYLATION; SOMATIC TISSUES; TRANSCRIPTIONAL ACTIVITY;

DNA; DNA SEQUENCES; GENES; HISTOLOGY; MAINTENANCE; MAMMALS; METHYLATION; STEM CELLS; TISSUE;

ALKYLATION;

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; DNA METHYLTRANSFERASE 3L; UNCLASSIFIED DRUG; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1;

ARTICLE; CONTROLLED STUDY; CYTOTROPHOBLAST; DNA METHYLATION; DNA SEQUENCE; DOWN REGULATION; ENZYME ACTIVITY; EPIGENETICS; GENE FUNCTION; GENE IDENTIFICATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PLACENTA; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STRUCTURAL GENOMICS; TROPHOBLAST; CELL DIFFERENTIATION; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PREGNANCY; STEM CELL;

MAMMALIA; PRIMATES;

BASE SEQUENCE; CELL DIFFERENTIATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MOLECULAR SEQUENCE DATA; PLACENTA; PREGNANCY; SEQUENCE ANALYSIS, DNA; STEM CELLS; TROPHOBLASTS;

EID: 77950368485     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064956     Document Type: Article

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