메뉴 건너뛰기




Volumn 67, Issue 9, 2010, Pages 840-845

The Role of Acetaldehyde in Human Psychomotor Function: A Double-Blind Placebo-Controlled Crossover Study

Author keywords

Acetaldehyde; alcohol; aldehyde dehydrogenase; ALDH2; car driving; psychomotor function

Indexed keywords

ACETALDEHYDE; ALCOHOL; PLACEBO;

EID: 77950367918     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.10.005     Document Type: Article
Times cited : (21)

References (40)
  • 1
    • 0029964474 scopus 로고    scopus 로고
    • Role of acetaldehyde in the actions of ethanol on the brain-a review
    • Hunt W.A. Role of acetaldehyde in the actions of ethanol on the brain-a review. Alcohol 13 (1996) 147-151
    • (1996) Alcohol , vol.13 , pp. 147-151
    • Hunt, W.A.1
  • 2
    • 0023130467 scopus 로고
    • Polymorphism of aldehyde dehydrogenase and alcohol sensitivity
    • Goedde H.W., and Agarwal D.P. Polymorphism of aldehyde dehydrogenase and alcohol sensitivity. Enzyme 37 (1987) 29-44
    • (1987) Enzyme , vol.37 , pp. 29-44
    • Goedde, H.W.1    Agarwal, D.P.2
  • 3
    • 34347252306 scopus 로고    scopus 로고
    • Overview: How is alcohol metabolized by the body?
    • Zakhari S. Overview: How is alcohol metabolized by the body?. Alcohol Res Health 29 (2006) 245-254
    • (2006) Alcohol Res Health , vol.29 , pp. 245-254
    • Zakhari, S.1
  • 4
    • 0020544348 scopus 로고
    • Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity
    • Goedde H.W., Agarwal D.P., Harada S., Meier-Tackmann D., Ruofu D., Bienzle U., et al. Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am J Hum Genet 35 (1983) 769-772
    • (1983) Am J Hum Genet , vol.35 , pp. 769-772
    • Goedde, H.W.1    Agarwal, D.P.2    Harada, S.3    Meier-Tackmann, D.4    Ruofu, D.5    Bienzle, U.6
  • 5
    • 0026907527 scopus 로고
    • Molecular genetics of human aldehyde dehydrogenase
    • Yoshida A. Molecular genetics of human aldehyde dehydrogenase. Pharmacogenetics 2 (1992) 139-147
    • (1992) Pharmacogenetics , vol.2 , pp. 139-147
    • Yoshida, A.1
  • 6
    • 0030851067 scopus 로고    scopus 로고
    • Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism
    • Shen Y.C., Fan J.H., Edenberg H.J., Li T.K., Cui Y.H., Wang Y.F., et al. Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 21 (1997) 1272-1277
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 1272-1277
    • Shen, Y.C.1    Fan, J.H.2    Edenberg, H.J.3    Li, T.K.4    Cui, Y.H.5    Wang, Y.F.6
  • 7
    • 1242293691 scopus 로고    scopus 로고
    • Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population
    • Kim J.M., Stewart R., Shin I.S., Jung J.S., and Yoon J.S. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. Neurobiol Aging 25 (2004) 295-301
    • (2004) Neurobiol Aging , vol.25 , pp. 295-301
    • Kim, J.M.1    Stewart, R.2    Shin, I.S.3    Jung, J.S.4    Yoon, J.S.5
  • 9
    • 33645994477 scopus 로고    scopus 로고
    • ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American College students
    • Luczak S.E., Shea S.H., Hsueh A.C., Chang J., Carr L.G., and Wall T.L. ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American College students. J Stud Alcohol 67 (2006) 349-353
    • (2006) J Stud Alcohol , vol.67 , pp. 349-353
    • Luczak, S.E.1    Shea, S.H.2    Hsueh, A.C.3    Chang, J.4    Carr, L.G.5    Wall, T.L.6
  • 10
    • 40549085694 scopus 로고    scopus 로고
    • Major genetic components underlying alcoholism in Korean population
    • Kim D.J., Choi I.G., Park B.L., Lee B.C., Ham B.J., Yoon S., et al. Major genetic components underlying alcoholism in Korean population. Hum Mol Genet 17 (2008) 854-858
    • (2008) Hum Mol Genet , vol.17 , pp. 854-858
    • Kim, D.J.1    Choi, I.G.2    Park, B.L.3    Lee, B.C.4    Ham, B.J.5    Yoon, S.6
  • 11
    • 0018736738 scopus 로고
    • Acetaldehyde in cerebrospinal fluid: Its near-absence in ethanol-intoxicated alcoholics
    • Lindros K.O., and Hillbom M.E. Acetaldehyde in cerebrospinal fluid: Its near-absence in ethanol-intoxicated alcoholics. Med Biol 57 (1979) 246-247
    • (1979) Med Biol , vol.57 , pp. 246-247
    • Lindros, K.O.1    Hillbom, M.E.2
  • 12
    • 0018815814 scopus 로고
    • Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods
    • Stowell A., Hillbom M., Salaspuro M., and Lindros K.O. Low acetaldehyde levels in blood, breath and cerebrospinal fluid of intoxicated humans as assayed by improved methods. Adv Exp Med Biol 132 (1980) 635-645
    • (1980) Adv Exp Med Biol , vol.132 , pp. 635-645
    • Stowell, A.1    Hillbom, M.2    Salaspuro, M.3    Lindros, K.O.4
  • 13
    • 1342306772 scopus 로고    scopus 로고
    • Is ethanol a pro-drug?. Role of acetaldehyde in the central effects of ethanol
    • Quertemont E., and Tambour S. Is ethanol a pro-drug?. Role of acetaldehyde in the central effects of ethanol. Trends Pharmacol Sci 25 (2004) 130-134
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 130-134
    • Quertemont, E.1    Tambour, S.2
  • 14
    • 0031789210 scopus 로고    scopus 로고
    • Distribution and kinetics of ethanol metabolism in rat brain
    • Zimatkin S.M., Liopo A.V., and Deitrich R.A. Distribution and kinetics of ethanol metabolism in rat brain. Alcohol Clin Exp Res 22 (1998) 1623-1627
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1623-1627
    • Zimatkin, S.M.1    Liopo, A.V.2    Deitrich, R.A.3
  • 15
    • 12144261894 scopus 로고    scopus 로고
    • Behavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic, anxiolytic and amnesic effects
    • Quertemont E., Tambour S., Bernaerts P., Zimatkin S.M., and Tirelli E. Behavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic, anxiolytic and amnesic effects. Psychopharmacology 177 (2004) 84-92
    • (2004) Psychopharmacology , vol.177 , pp. 84-92
    • Quertemont, E.1    Tambour, S.2    Bernaerts, P.3    Zimatkin, S.M.4    Tirelli, E.5
  • 17
    • 40849112815 scopus 로고    scopus 로고
    • Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation
    • McLaughlin P.J., Chuck T.L., Arizzi-LaFrance M.N., Salamone J.D., and Correa M. Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation. Pharmacol Biochem Behav 89 (2008) 304-313
    • (2008) Pharmacol Biochem Behav , vol.89 , pp. 304-313
    • McLaughlin, P.J.1    Chuck, T.L.2    Arizzi-LaFrance, M.N.3    Salamone, J.D.4    Correa, M.5
  • 18
    • 0027296650 scopus 로고
    • Effects of alcohol on the EEG in Asian men with genetic variations of ALDH2
    • Wall T.L., Gallen C.C., and Ehlers C.L. Effects of alcohol on the EEG in Asian men with genetic variations of ALDH2. Biol Psychiatry 34 (1993) 91-99
    • (1993) Biol Psychiatry , vol.34 , pp. 91-99
    • Wall, T.L.1    Gallen, C.C.2    Ehlers, C.L.3
  • 19
    • 0029069175 scopus 로고
    • Acute effects of alcohol on P300 in Asians with different ALDH2 genotypes
    • Wall T.L., and Ehlers C.L. Acute effects of alcohol on P300 in Asians with different ALDH2 genotypes. Alcohol Clin Exp Res 19 (1995) 617-622
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 617-622
    • Wall, T.L.1    Ehlers, C.L.2
  • 20
    • 33646348718 scopus 로고    scopus 로고
    • ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: A double-blind placebo-controlled crossover study
    • Shin H.Y., Shin I.S., and Yoon J.S. ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: A double-blind placebo-controlled crossover study. Hum Psychopharmacol 21 (2006) 159-166
    • (2006) Hum Psychopharmacol , vol.21 , pp. 159-166
    • Shin, H.Y.1    Shin, I.S.2    Yoon, J.S.3
  • 24
    • 14944349126 scopus 로고    scopus 로고
    • A preliminary study on the Korean translation of composite scale. (KtCS) to measure morningness-eveningness
    • Yoon J.S., Shin S.M., Kook S.H., and Lee H.Y. A preliminary study on the Korean translation of composite scale. (KtCS) to measure morningness-eveningness. J Korean Neuropsychiatr Assoc 36 (1997) 122-134
    • (1997) J Korean Neuropsychiatr Assoc , vol.36 , pp. 122-134
    • Yoon, J.S.1    Shin, S.M.2    Kook, S.H.3    Lee, H.Y.4
  • 25
    • 0021199110 scopus 로고
    • Detecting alcoholism: The CAGE questionnaire
    • Ewing J.A. Detecting alcoholism: The CAGE questionnaire. JAMA 252 (1984) 1905-1907
    • (1984) JAMA , vol.252 , pp. 1905-1907
    • Ewing, J.A.1
  • 26
    • 0027154845 scopus 로고
    • Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption II
    • Saunders J.B., Aasland O.G., Babor T.F., Delafuente J.R., and Grant M. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption II. Addiction 88 (1993) 791-804
    • (1993) Addiction , vol.88 , pp. 791-804
    • Saunders, J.B.1    Aasland, O.G.2    Babor, T.F.3    Delafuente, J.R.4    Grant, M.5
  • 27
    • 34547130059 scopus 로고    scopus 로고
    • Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men
    • Yokoyama A., Tsutsumi E., Imazeki H., Suwa Y., Nakamura C., and Yokoyama T. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer 121 (2007) 1047-1054
    • (2007) Int J Cancer , vol.121 , pp. 1047-1054
    • Yokoyama, A.1    Tsutsumi, E.2    Imazeki, H.3    Suwa, Y.4    Nakamura, C.5    Yokoyama, T.6
  • 28
    • 0026588940 scopus 로고
    • The effects of alcohol on the cognitive function of males and females and on skills related to car driving
    • Hindmarch I., Starmer G.A., Mascord D.J., Kerr J.S., and Sherwood N. The effects of alcohol on the cognitive function of males and females and on skills related to car driving. Hum Psychopharmacol 7 (1992) 105-114
    • (1992) Hum Psychopharmacol , vol.7 , pp. 105-114
    • Hindmarch, I.1    Starmer, G.A.2    Mascord, D.J.3    Kerr, J.S.4    Sherwood, N.5
  • 29
    • 0035090020 scopus 로고    scopus 로고
    • Effects of tianeptine and mianserin on car driving skills
    • Ridout F., and Hindmarch I. Effects of tianeptine and mianserin on car driving skills. Psychopharmacology 154 (2001) 356-361
    • (2001) Psychopharmacology , vol.154 , pp. 356-361
    • Ridout, F.1    Hindmarch, I.2
  • 30
    • 0037701635 scopus 로고    scopus 로고
    • A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance
    • Ridout F., Meadows R., Johnsen S., and Hindmarch I. A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance. Hum Psychopharmacol 18 (2003) 261-269
    • (2003) Hum Psychopharmacol , vol.18 , pp. 261-269
    • Ridout, F.1    Meadows, R.2    Johnsen, S.3    Hindmarch, I.4
  • 31
    • 27744546313 scopus 로고    scopus 로고
    • A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers
    • Hindmarch I., Trick L., and Ridout F. A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers. Psychopharmacology 183 (2005) 133-143
    • (2005) Psychopharmacology , vol.183 , pp. 133-143
    • Hindmarch, I.1    Trick, L.2    Ridout, F.3
  • 32
    • 0002035231 scopus 로고
    • Critical flicker fusion frequency (CFF): The effects of psychotropic compounds
    • Hindmarch I. Critical flicker fusion frequency (CFF): The effects of psychotropic compounds. Pharmacopsychiatrica 15 suppl 1 (1982) S44-S48
    • (1982) Pharmacopsychiatrica , vol.15 , Issue.SUPPL. 1
    • Hindmarch, I.1
  • 33
    • 0017758176 scopus 로고
    • Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance
    • Hindmarch I., and Parrott A.C. Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. Br J Clin Pharmacol 4 suppl 2 (1977) S167-S173
    • (1977) Br J Clin Pharmacol , vol.4 , Issue.SUPPL. 2
    • Hindmarch, I.1    Parrott, A.C.2
  • 34
    • 84995202150 scopus 로고
    • The effects of simeldine and amitriptyline on car driving and psychomotor performance
    • Hindmarch I., Subhan S., and Stoker M.J. The effects of simeldine and amitriptyline on car driving and psychomotor performance. Acta Psychiatr Scand 68 (1983) 141-146
    • (1983) Acta Psychiatr Scand , vol.68 , pp. 141-146
    • Hindmarch, I.1    Subhan, S.2    Stoker, M.J.3
  • 38
    • 0029920630 scopus 로고    scopus 로고
    • Inhibitory mechanism of intestinal ethanol absorption induced by high acetaldehyde concentrations: Effect of intestinal blood flow and substance specificity
    • Kinoshita H., Ijiri I., Ameno S., Fuke C., Fujisawa Y., and Ameno K. Inhibitory mechanism of intestinal ethanol absorption induced by high acetaldehyde concentrations: Effect of intestinal blood flow and substance specificity. Alcohol Clin Exp Res 20 (1996) 510-513
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 510-513
    • Kinoshita, H.1    Ijiri, I.2    Ameno, S.3    Fuke, C.4    Fujisawa, Y.5    Ameno, K.6
  • 39
    • 18844448134 scopus 로고    scopus 로고
    • The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies
    • Quertemont E., Tambour S., and Tirelli E. The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies. Prog Neurobiol 75 (2005) 247-274
    • (2005) Prog Neurobiol , vol.75 , pp. 247-274
    • Quertemont, E.1    Tambour, S.2    Tirelli, E.3
  • 40
    • 40849112815 scopus 로고    scopus 로고
    • Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation
    • McLaughlin P.J., Chuck T.L., Arizzi-LaFrance M.N., Salamone J.D., and Correa M. Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation. Pharmacol Biochem Behav 89 (2008) 304-313
    • (2008) Pharmacol Biochem Behav , vol.89 , pp. 304-313
    • McLaughlin, P.J.1    Chuck, T.L.2    Arizzi-LaFrance, M.N.3    Salamone, J.D.4    Correa, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.