A little 'help' from IL-21 during persistent viral infection

Journal of Molecular Cell Biology

Volumn 2, Issue 1, 2010, Pages 8-10

  McGavern, Dorian B ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN DERIVATIVE;

ANIMAL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MOUSE MUTANT; PHYSIOLOGY; VIROLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKINS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, KNOCKOUT;

EID: 77950346880     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjp021     Document Type: Article

References (15)

1. Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M., and Oldstone, M. B. (1984). Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521-540. (Pubitemid 14052514)
2. Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., and Ahmed, R. (2006). Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687. (Pubitemid 43237609)
3. Bergthaler, A., Flatz, L., Verschoor, A., Hegazy, A. N., Holdener, M., Fink, K., Eschli, B., Merkler, D., Sommerstein, R., Horvath, E., et al. (2009). Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol. 7, e1000080.
4. + T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29-37.
5. Brooks, D. G., Teyton, L., Oldstone, M. B., and McGavern, D. B. (2005). Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. J. Virol. 79, 10514-10527. (Pubitemid 41098591)
6. Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., and Oldstone, M. B. (2006). Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 12, 1301-1309. (Pubitemid 44706933)
7. Elsaesser, H., Sauer, K., and Brooks, D. G. (2009). IL-21 is required to control chronic viral infection. Science 324, 1569-1572.
8. Frohlich, A., Kisielow, J., Schmitz, I., Freigang, S., Shamshiev, A. T., Weber, J., Marsland, B. J., Oxenius, A., and Kopf, M. (2009). IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science 324, 1576-1580.
9. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68, 8056-8063. (Pubitemid 24362694)
10. Pfau, C. J., Valenti, J. K., Pevear, D. C., and Hunt, K. D. (1982). Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections. J. Exp. Med. 156, 79-89. (Pubitemid 12082489)
11. Spolski, R., and Leonard, W. J. (2008). Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26, 57-79. (Pubitemid 351600371)
12. Velu, V., Titanji, K., Zhu, B., Husain, S., Pladevega, A., Lai, L., Vanderford, T. H., Chennareddi, L., Silvestri, G., Freeman, G. J., et al. (2009). Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458, 206-210.
13. Virgin, H. W., Wherry, E. J., and Ahmed, R. (2009). Redefining chronic viral infection. Cell 138, 30-50.
14. Yi, J. S., Du, M., and Zajac, A. J. (2009). A vital role for interleukin-21 in the control of a chronic viral infection. Science 324, 1572-1576.
15. Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J., Suresh, M., Altman, J. D., and Ahmed, R. (1998). Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205-2213. (Pubitemid 29028493)