Nonacute Coronary Syndrome Anginal Chest Pain

Medical Clinics of North America

Volumn 94, Issue 2, 2010, Pages 201-216

  Agarwal, Megha ^a   Mehta, Puja K ^a   Bairey Merz, C Noel ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Chest pain; Chronic stable angina; Microvascular angina; Stress testing

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; ADENOSINE; AMLODIPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; DOBUTAMINE; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RANOLAZINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANGIOCARDIOGRAPHY; ATRIOVENTRICULAR BLOCK; BLOOD VESSEL REACTIVITY; BRONCHOSPASM; CHOLESTEROL BLOOD LEVEL; CHRONIC DISEASE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY THROMBOSIS; DRUG EFFECT; ELECTROCARDIOGRAPHY; FLUSHING; HEADACHE; HEART MUSCLE ISCHEMIA; HUMAN; LOW DRUG DOSE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOSTATIC HYPOTENSION; PATHOPHYSIOLOGY; PERCUTANEOUS CORONARY INTERVENTION; POSITRON EMISSION TOMOGRAPHY; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; RISK FACTOR; SIDE EFFECT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STABLE ANGINA PECTORIS; STRESS ECHOCARDIOGRAPHY; THORAX PAIN; THROMBOSIS PREVENTION; TREADMILL EXERCISE; TREATMENT CONTRAINDICATION; TREATMENT INDICATION;

AGE FACTORS; ANGINA PECTORIS; CARDIOVASCULAR AGENTS; CHEST PAIN; CORONARY DISEASE; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC IMAGING; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; HUMANS; MALE; MYOCARDIAL REVASCULARIZATION; RISK FACTORS; SEX FACTORS; SYNDROME;

EID: 77950306802     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcna.2010.01.008     Document Type: Review

References (87)

1. Pepine C.J., and Nichols W.W. The pathophysiology of chronic ischemic heart disease. Clin Cardiol 30 S1 (2007) I4-I9
2. Rubio R., and Berne R.M. Regulation of coronary blood flow. Prog Cardiovasc Dis 18 2 (1975) 105-122
3. Tune J.D., Gorman M.W., and Feigl E.O. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97 1 (2004) 404-415
4. Foreman R.D. Mechanisms of visceral pain: from nociception to targets. Drug Discov Today Dis Mech 1 4 (2004) 457-463
5. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348 9038 (1996) 1329-1339
6. Libby P. Inflammation in atherosclerosis. Nature 420 6917 (2002) 868-874
7. Libby P., and Theroux P. Pathophysiology of coronary artery disease. Circulation 111 25 (2005) 3481-3488
8. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 6423 (1993) 801-809
9. Traub O., and Berk B.C. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 18 5 (1998) 677-685
10. Bruschke A.V., Kramer Jr. J.R., Bal E.T., et al. The dynamics of progression of coronary atherosclerosis studied in 168 medically treated patients who underwent coronary arteriography three times. Am Heart J 117 2 (1989) 296-305
11. Glagov S., Weisenberg E., Zarins C.K., et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316 22 (1987) 1371-1375
12. Mosseri M., Yarom R., Gotsman M.S., et al. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation 74 5 (1986) 964-972
13. Cannon III R.O., Watson R.M., Rosing D.R., et al. Angina caused by reduced vasodilator reserve of the small coronary arteries. J Am Coll Cardiol 1 6 (1983) 1359-1373
14. Egashira K., Inou T., Hirooka Y., et al. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med 328 23 (1993) 1659-1664
15. Opherk D., Zebe H., Weihe E., et al. Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms. Circulation 63 4 (1981) 817-825
16. Sakr S.A., Abbas T.M., Amer M.Z., et al. Microvascular angina. The possible role of inflammation, uric acid, and endothelial dysfunction. Int Heart J 50 4 (2009) 407-419
17. Kaski J.C. Cardiac syndrome X in women: the role of oestrogen deficiency. Heart 92 Suppl 3 (2006) iii5-iii9
18. Mohri M., Koyanagi M., Egashira K., et al. Angina pectoris caused by coronary microvascular spasm. Lancet 351 9110 (1998) 1165-1169
19. Hodgson J.M., and Marshall J.J. Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries. Circulation 79 5 (1989) 1043-1051
20. Okumura K., Yasue H., Horio Y., et al. Multivessel coronary spasm in patients with variant angina: a study with intracoronary injection of acetylcholine. Circulation 77 3 (1988) 535-542
21. Prinzmetal M., Kennamer R., Merliss R., et al. Angina pectoris I. A variant form of angina pectoris; preliminary report. Am J Med 27 (1959) 375-388
22. Hung M.J., Cherng W.J., Yang N.I., et al. Relation of high-sensitivity C-reactive protein level with coronary vasospastic angina pectoris in patients without hemodynamically significant coronary artery disease. Am J Cardiol 96 11 (2005) 1484-1490
23. Li J.J., Zhang Y.P., Yang P., et al. Increased peripheral circulating inflammatory cells and plasma inflammatory markers in patients with variant angina. Coron Artery Dis 19 5 (2008) 293-297
24. Kawano H., and Ogawa H. Endothelial function and coronary spastic angina. Intern Med 44 2 (2005) 91-99
25. Miyao Y., Kugiyama K., Kawano H., et al. Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 36 2 (2000) 432-437
26. Julius B.K., Spillmann M., Vassalli G., et al. Angina pectoris in patients with aortic stenosis and normal coronary arteries. Mechanisms and pathophysiological concepts. Circulation 95 4 (1997) 892-898
27. Gould K.L. Why angina pectoris in aortic stenosis. Circulation 95 4 (1997) 790-792
28. Hittinger L., Mirsky I., Shen Y.-T., et al. Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy. Circulation 92 4 (1995) 978-986
29. Masuyama T., Uematsu M., Doi Y., et al. Abnormal coronary flow dynamics at rest and during tachycardia associated with impaired left ventricular relaxation in humans: implication for tachycardia-induced myocardial ischemia. J Am Coll Cardiol 24 7 (1994) 1625-1632
30. Gould K.L., and Carabello B.A. Why angina in aortic stenosis with normal coronary arteriograms?. Circulation 107 25 (2003) 3121-3123
31. Weidemann F., Herrmann S., Stork S., et al. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation 120 7 (2009) 577-584
32. Angelini P., Velasco J.A., and Flamm S. Coronary anomalies: incidence, pathophysiology, and clinical relevance. Circulation 105 20 (2002) 2449-2454
33. Angelini P. Functionally significant versus intriguingly different coronary artery anatomy: anatomo-clinical correlations in coronary anomalies. G Ital Cardiol 29 6 (1999) 607-615
34. Levin D.C., Fellows K.E., and Abrams H.L. Hemodynamically significant primary anomalies of the coronary arteries. Angiographic aspects. Circulation 58 1 (1978) 25-34
35. Freed L.A., Levy D., Levine R.A., et al. Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med 341 1 (1999) 1-7
36. Vavuranakis M., Kolibash A.J., Wooley C.F., et al. Mitral valve prolapse: left ventricular hemodynamics in patients with chest pain, dyspnea or both. J Heart Valve Dis 2 5 (1993) 544-549
37. Alpert M.A., Mukerji V., Sabeti M., et al. Mitral valve prolapse, panic disorder, and chest pain. Med Clin North Am 75 5 (1991) 1119-1133
38. Cannon III R., Quyyumi A., Schenke W., et al. Abnormal cardiac sensitivity in patients with chest pain and normal coronary arteries. J Am Coll Cardiol 16 6 (1990) 1359-1366
39. Chauhan A., Mullins P., Thuraisingham S., et al. Abnormal cardiac pain perception in syndrome X. J Am Coll Cardiol 24 2 (1994) 329-335
40. Shapiro L.M., Crake T., and Poole-Wilson P.A. Is altered cardiac sensation responsible for chest pain in patients with normal coronary arteries? Clinical observation during cardiac catheterisation. Br Med J (Clin Res Ed) 296 6616 (1988) 170-171
41. Rosen S.D., Paulesu E., Wise R.J., et al. Central neural contribution to the perception of chest pain in cardiac syndrome X. Heart 87 6 (2002) 513-519
42. Valeriani M., Sestito A., Pera D.L., et al. Abnormal cortical pain processing in patients with cardiac syndrome X. Eur Heart J 26 10 (2005) 975-982
43. Snow V., Barry P., Fihn S.D., et al. Evaluation of primary care patients with chronic stable angina: guidelines from the American College of Physicians. Ann Intern Med 141 1 (2004) 57-64
44. Bugiardini R., and Bairey Merz C.N. Angina with "normal" coronary arteries: a changing philosophy. JAMA 293 4 (2005) 477-484
45. Fraker Jr. T.D., Fihn S.D., Gibbons R.J., et al. 2007 chronic angina focused update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina. J Am Coll Cardiol 50 23 (2007) 2264-2274
46. Fraker Jr. T.D., Fihn S.D., Gibbons R.J., et al. 2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation 116 23 (2007) 2762-2772
47. Gibbons R.J., Balady G.J., Bricker J.T., et al. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation 106 14 (2002) 1883-1892
48. Williams S.V., Fihn S.D., and Gibbons R.J. Guidelines for the management of patients with chronic stable angina: diagnosis and risk stratification. Ann Intern Med 135 7 (2001) 530-547
49. Fox K., Garcia M.A., Ardissino D., et al. Guidelines on the management of stable angina pectoris: executive summary: the Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 27 11 (2006) 1341-1381
50. Connolly D.C., Elveback L.R., and Oxman H.A. Coronary heart disease in residents of Rochester, Minnesota IV. Prognostic value of the resting electrocardiogram at the time of initial diagnosis of angina pectoris. Mayo Clin Proc 59 4 (1984) 247-250
51. Kannel W.B., Dawber T.R., Kagan A., et al. Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann Intern Med 55 (1961) 33-50
52. Daly C., Norrie J., Murdoch D.L., et al. The value of routine non-invasive tests to predict clinical outcome in stable angina. Eur Heart J 24 6 (2003) 532-540
53. Kannel W.B., Anderson K., McGee D.L., et al. Nonspecific electrocardiographic abnormality as a predictor of coronary heart disease: the Framingham study. Am Heart J 113 2 Pt 1 (1987) 370-376
54. De Bacquer D., De Backer G., Kornitzer M., et al. Prognostic value of ECG findings for total, cardiovascular disease, and coronary heart disease death in men and women. Heart 80 6 (1998) 570-577
55. Nasir K., Redberg R.F., Budoff M.J., et al. Utility of stress testing and coronary calcification measurement for detection of coronary artery disease in women. Arch Intern Med 164 15 (2004) 1610-1620
56. Sharples L., Hughes V., Crean A., et al. Cost-effectiveness of functional cardiac testing in the diagnosis and management of coronary artery disease: a randomised controlled trial. The CECaT trial. Health Technol Assess 11 49 (2007) iii-iv ix-115
57. Lewis J.F., McGorray S., Lin L., et al. Exercise treadmill testing using a modified exercise protocol in women with suspected myocardial ischemia: findings from the National Heart, Lung and Blood Institute-sponsored women's ischemia syndrome evaluation (WISE). Am Heart J 149 3 (2005) 527-533
58. Travain M.I., and Wexler J.P. Pharmacological stress testing. Semin Nucl Med 29 4 (1999) 298-318
59. Leppo J.A. Comparison of pharmacologic stress agents. J Nucl Cardiol 3 6 Pt 2 (1996) S22-S26
60. Leppo J.A., O'Brien J., Rothendler J.A., et al. Dipyridamole-thallium-201 scintigraphy in the prediction of future cardiac events after acute myocardial infarction. N Engl J Med 310 16 (1984) 1014-1018
61. Mahmarian J.J., Mahmarian A.C., Marks G.F., et al. Role of adenosine thallium-201 tomography for defining long-term risk in patients after acute myocardial infarction. J Am Coll Cardiol 25 6 (1995) 1333-1340
62. Schwitter J., Nanz D., Kneifel S., et al. Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography. Circulation 103 18 (2001) 2230-2235
63. Gershlick A.H., de Belder M., Chambers J., et al. Role of non-invasive imaging in the management of coronary artery disease: an assessment of likely change over the next 10 years. A report from the British Cardiovascular Society Working Group. Heart 93 4 (2007) 423-431
64. Bengel F.M., Higuchi T., Javadi M.S., et al. Cardiac positron emission tomography. J Am Coll Cardiol 54 1 (2009) 1-15
65. Knuuti J., and Bengel F.M. Positron emission tomography and molecular imaging. Heart 94 3 (2008) 360-367
66. Dendukuri N., Chiu K., and Brophy J. Validity of electron beam computed tomography for coronary artery disease: a systematic review and meta-analysis. BMC Med 5 1 (2007) 35
67. Redberg R.F., and Shaw L.J. A review of electron beam computed tomography: implications for coronary artery disease screening. Prev Cardiol 5 2 (2002) 71-78
68. Achenbach S., Hoffmann U., Ferencik M., et al. Tomographic coronary angiography by EBCT and MDCT. Prog Cardiovasc Dis 46 2 (2003) 185-195
69. Garcia M.J. Non-invasive tests in coronary artery disease: are we facing a fork in the road?. Heart 93 4 (2007) 413-414
70. Lerman A., and Sopko G. Women and cardiovascular heart disease: clinical implications from the women's ischemia syndrome evaluation (WISE) study: are we smarter?. J Am Coll Cardiol 47 3 Suppl 1 (2006) S59-S62
71. Phan A., Shufelt C., and Merz C.N. Persistent chest pain and no obstructive coronary artery disease. JAMA 301 14 (2009) 1468-1474
72. Boden W.E., O'Rourke R.A., Teo K.K., et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 356 15 (2007) 1503-1516
73. Katritsis D.G., and Ioannidis J.P. Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation 111 22 (2005) 2906-2912
74. Baigent C., Sudlow C., Collins R., et al. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324 7329 (2002) 71-86
75. Grundy S.M., Cleeman J.I., Bairey Merz C.N., et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol 44 3 (2004) 720-732
76. Pepine C., Cohn P., Deedwania P., et al. Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life. The Atenolol silent ischemia study (ASIST). Circulation 90 2 (1994) 762-768
77. Yusuf S., Wittes J., and Friedman L. Overview of results of randomized clinical trials in heart disease I. Treatments following myocardial infarction. JAMA 260 14 (1988) 2088-2093
78. Nissen S.E., Tuzcu E.M., Libby P., et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: The CAMELOT study: a randomized controlled trial. JAMA 292 18 (2004) 2217-2225
79. Chaitman B.R. Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions. Circulation 113 20 (2006) 2462-2472
80. Chaitman B.R., Pepine C.J., Parker J.O., et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA 291 3 (2004) 309-316
81. Chaitman B.R., Skettino S.L., Parker J.O., et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol 43 8 (2004) 1375-1382
82. Stone P.H., Gratsiansky N.A., Blokhin A., et al. Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (efficacy of ranolazine in chronic angina) trial. J Am Coll Cardiol 48 3 (2006) 566-575
83. Melloni C., and Newby L.K. Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study. Expert Rev Cardiovasc Ther 6 1 (2008) 9-16
84. Morrow D.A., Scirica B.M., Karwatowska-Prokopczuk E., et al. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA 297 16 (2007) 1775-1783
85. Wilson S.R., Scirica B.M., Braunwald E., et al. Efficacy of ranolazine in patients with chronic angina: observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (metabolic efficiency with ranolazine for less ischemia in non-ST-segment elevation acute coronary syndromes) 36 trial. J Am Coll Cardiol 53 17 (2009) 1510-1516
86. Jones R.H., Kesler K., Phillips III H.R., et al. Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease. J Thorac Cardiovasc Surg 111 5 (1996) 1013-1025
87. Rihal C.S., Raco D.L., Gersh B.J., et al. Indications for coronary artery bypass surgery and percutaneous coronary intervention in chronic stable angina: review of the evidence and methodological considerations. Circulation 108 20 (2003) 2439-2445