Association between APOE ε4 allele and vascular dementia: The cache county study

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 3, 2010, Pages 248-253

  Chuang, Yi Fang ^a   Hayden, Kathleen M ^b   Norton, Maria C ^c   Tschanz, Joann ^c   Breitner, John C S ^d   Welsh Bohmer, Kathleen A ^b   Zandi, Peter P ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UTAH STATE UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

APOE; Vascular dementia

Indexed keywords

APOLIPOPROTEIN E4;

AGED; AGING; ALLELE; ARTICLE; COGNITIVE DEFECT; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTIINFARCT DEMENTIA; PRIORITY JOURNAL; QUESTIONNAIRE; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE; COGNITION; GENE DOSAGE; GENETICS; KAPLAN MEIER METHOD; LONGITUDINAL STUDY; MIDDLE AGED; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGICAL RATING SCALE; SURVIVAL; UNITED STATES; VASCULAR DISEASE;

AGED; APOLIPOPROTEIN E4; COGNITION; DEMENTIA, VASCULAR; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENOTYPE; HUMANS; KAPLAN-MEIERS ESTIMATE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; SURVIVAL ANALYSIS; UTAH; VASCULAR DISEASES;

EID: 77950303632     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000285166     Document Type: Article

References (40)

1. Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, Burke JR, Hurd MD, Potter GG, Rodgers WL, Steffens DC, Willis RJ, Wallace RB: Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology 2007; 29: 125-132.
2. Hill J, Fillit H, Shah SN, del Valle MC, Futterman R: Patterns of healthcare utilization and costs for vascular dementia in a community- dwelling population. J Alzheimers Dis 2005; 8: 43-50. (Pubitemid 41267322)
3. Kamboh MI: Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet 2004; 68: 381-404. (Pubitemid 39162750)
4. Williamson J, Goldman J, Marder KS: Genetic aspects of Alzheimer disease. Neurologist 2009; 15: 80-86.
5. Mahley RW: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240: 622-630.
6. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak- Vance MA, Risch N, van Duijn CM: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. APOE and Alzheimer Disease Meta-Analysis Consortium. JAMA 1997; 278: 1349-1356.
7. Davidson Y, Gibbons L, Purandare N, Byrne J, Hardicre J, Wren J, Payton A, Pendleton N, Horan M, Burns A, Mann DM: Apolipoprotein Eε 4 allele frequency in vascular dementia. Dement Geriatr Cogn Disord 2006; 22: 15-19. (Pubitemid 43909823)
8. Baum L, Lam LC, Kwok T, Lee J, Chiu HF, Mok VC, Wong A, Chen X, Cheung WS, Pang CP, Ma SL, Tang NL, Wong KS, Ng HK: Apolipoprotein Eε 4 allele is associated with vascular dementia. Dement Geriatr Cogn Disord 2006; 22: 301-305. (Pubitemid 44651443)
9. Yang J, Feng G, Zhang J, Hui Z, Breen G, St Clair D, He L: Is APOE gene a risk factor for vascular dementia in Han Chinese? Int J Mol Med 2001; 7: 217-219.
10. Katzman R, Zhang MY, Chen PJ, Gu N, Jiang S, Saitoh T, Chen X, Klauber M, Thomas RG, Liu WT, Yu ES: Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia. Neurology 1997; 49: 779-785. (Pubitemid 27428022)
11. Slooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R: Apolipoprotein Eε 4 and the risk of dementia with stroke: a population-based investigation. JAMA 1997; 277: 818-821. (Pubitemid 27111318)
12. Kálmán J, Juhász A, Császár A, Kanka A, Rimanóczy A, Janka Z, Raskó I: Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population. Acta Neurol Scand 1998; 98: 166-168. (Pubitemid 28435309)
13. Kim KW, Youn JC, Han MK, Paik NJ, Lee TJ, Park JH, Lee SB, Choo IH, Lee DY, Jhoo JH, Woo JI: Lack of association between apolipoprotein E polymorphism and vascular dementia in Koreans. J Geriatr Psychiatry Neurol 2008; 21: 12-17.
14. Engelborghs S, Dermaut B, Goeman J, Saerens J, Mariën P, Pickut BA, van den Broeck M, Serneels S, Cruts M, van Broeckhoven C, de Deyn PP: Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects. J Neurol Neurosurg Psychiatry 2003; 74: 1148-1151. (Pubitemid 36936404)
15. Lin HF, Lai CL, Tai CT, Lin RT, Liu CK: Apolipoprotein E polymorphism in ischemic cerebrovascular diseases and vascular dementia patients in Taiwan. Neuroepidemiology 2004; 23: 129-134. (Pubitemid 38490223)
16. Nakayama S, Kuzuhara S: Apolipoprotein E phenotypes in healthy normal controls and demented subjects with Alzheimer's disease and vascular dementia in Mie Prefecture of Japan. Psychiatry Clin Neurosci 1999; 53: 643-648.
17. Stengard JH, Pekkanen J, Sulkava R, Ehnholm C, Erkinjuntti T, Nissinen A: Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men. Acta Neurol Scand 1995; 92: 297-298.
18. Miech RA, Breitner JC, Zandi PP, Khachaturian AS, Anthony JC, Mayer L: Incidence of AD may decline in the early 90s for men, later for women: the Cache County Study. Neurology 2002; 58: 209-218. (Pubitemid 34084209)
19. Breitner JC, Wyse BW, Anthony JC, Welsh- Bohmer KA, Steffens DC, Norton MC, Tschanz JT, Plassman BL, Meyer MR, Skoog I, Khachaturian A: APOEε 4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology 1999; 53: 321-331. (Pubitemid 29344354)
20. Tschanz JT, Welsh-Bohmer KA, Plassman BL, Norton MC, Wyse BW, Breitner JC: An adaptation of the modified Mini-Mental State Examination: analysis of demographic influences and normative data - the Cache County Study. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15: 28-38.
21. Teng EL, Chui HC: The Modified Mini- Mental State (3MS) examination. J Clin Psychiatry 1987; 48: 314-318.
22. Jorm AF, Jacomb PA: The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med 1989; 19: 1015-1022.
23. Silverman JM, Breitner JC, Mohs RC, Davis KL: Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias. Am J Psychiatry 1986; 143: 1279-1282.
24. Cummings JL, Mega M, Gray K, Rosenberg- Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994; 44: 2308-2314. (Pubitemid 24382728)
25. Clark CM, Ewbank DC: Performance of the Dementia Severity Rating Scale: a caregiver questionnaire for rating severity in Alzheimer disease. Alzheimer Dis Assoc Disord 1996; 10: 31-39.
26. Tschanz JT, Welsh-Bohmer KA, Skoog I, West N, Norton MC, Wyse BW, Nickles R, Breitner JC: Dementia diagnoses from clinical and neuropsychological data compared: the Cache County Study. Neurology 2000; 54: 1290-1296. (Pubitemid 30174049)
27. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3, rev (DSM-III-R). Washington, American Psychiatric Association, 1987.
28. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944. (Pubitemid 14076461)
29. Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, et al: Vascular dementia: diagnostic criteria for research studies. Report of the NINDSAIREN International Workshop. Neurology 1993; 43: 250-260.
30. Tatemichi TK, Sacktor N, Mayeux R: Dementia associated with cerebrovascular disease, other degenerative diseases, and metabolic disorders; in Terry RD, Katzman R, Bick KL (eds): Alzheimer Disease. New York, Raven, 1994, pp 123-166.
31. Hayden KM, Khachaturian AS, Tschanz JT, Corcoran C, Nortond M, Breitner JC: Characteristics of a two-stage screen for incident dementia. J Clin Epidemiol 2003; 56: 1038-1045. (Pubitemid 37386330)
32. Richards B, Skoletsky J, Shuber AP, Balfour R, Stern RC, Dorkin HL, Parad RB, Witt D, Klinger KW: Multiplex PCR amplification from the CFTR gene using DNA prepared from buccal brushes/swabs. Hum Mol Genet 1993; 2: 159-163. (Pubitemid 23075654)
33. Saunders AM, Roses AD: Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease. Stroke 1993; 24: 1416-1417. (Pubitemid 23254651)
34. Rockhill B, Newman B, Weinberg C: Use and misuse of population attributable fractions. Am J Public Health 1998; 88: 15-19.
35. Holmes C, Cairns N, Lantos P, Mann A: Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies. Br J Psychiatry 1999; 174: 45-50. (Pubitemid 29037883)
36. Luchsinger JA, Mayeux R: Cardiovascular risk factors and Alzheimer's disease. Curr Atheroscler Rep 2004; 6: 261-266. (Pubitemid 39359464)
37. Davignon J, Gregg RE, Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988; 8: 1-21. (Pubitemid 18049171)
38. Notkola IL, Sulkava R, Pekkanen J, Erkinjuntti T, Ehnholm C, Kivinen P, Tuomilehto J, Nissinen A: Serum total cholesterol, apolipoprotein Eε 4 allele, and Alzheimer's disease. Neuroepidemiology 1998; 17: 14-20. (Pubitemid 28153361)
39. Sparks DL: Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann NY Acad Sci 1997; 826: 128-146. (Pubitemid 27478036)
40. Prince M, Lovestone S, Cervilla J, Joels S, Powell J, Russ C, Mann A: The association between APOE and dementia does not seem to be mediated by vascular factors. Neurology 2000; 54: 397-402. (Pubitemid 30078071)