Adenovirus-mediated gene transfer of hIGF-IB in mouse lungs induced prolonged inflammation but no fibroproliferation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 4, 2010, Pages

  Léger, Caroline ^a   Ni, Ai ^b   Andonegui, Graciela ^a   Wong, Josée ^a,b   Mowat, Connie ^b   Winston, Brent W ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cytokines; Growth factors; Mouse model; Pulmonary fibrosis

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HUMAN INSULIN LIKE GROWTH FACTOR IB; MESSENGER RNA; SOMATOMEDIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY INFILTRATE; LUNG FIBROBLAST; LUNG FIBROSIS; MACROPHAGE; MALE; MESENCHYME CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TISSUE REPAIR; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN TYPE I; COLLAGEN TYPE III; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; LUNG; MALE; MICE; MICE, INBRED C57BL; PROTEIN ISOFORMS; PULMONARY FIBROSIS; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 77950303586     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00310.2009     Document Type: Article

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