A case-control association analysis of CABIN1 with schizophrenia in a Japanese population

Journal of Human Genetics

Volumn 55, Issue 3, 2010, Pages 179-181

  Watanabe, Yuichiro ^a,b   Nunokawa, Ayako ^a   Kaneko, Naoshi ^a   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

CABIN1; Case control study; Schizophrenia; Tagging SNP

Indexed keywords

BINDING PROTEIN; CALCINEURIN BINDING PROTEIN 1; UNCLASSIFIED DRUG; CABIN1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION; GENETICS; JAPAN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; JAPAN; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 77950293732     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1038/jhg.2009.136     Document Type: Article

References (20)

1. Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, P. R., Sotnikova, T. D., Zeng, H. et al. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc. Natl Acad. Sci. USA 100, 8987-8992 (2003).
2. Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D. et al. Genomewide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl Acad. Sci. USA 98, 4746-4751 (2001).
3. Eastwood, S. L., Burnet, P. W. & Harrison, P. J. Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Biol. Psychiatry 57, 702-710 (2005).
4. Kozlovsky, N., Scarr, E., Dean, B. & Agam, G. Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls. Schizophr. Res. 83, 173-177 (2006).
5. Gerber, D. J., Hall, D., Miyakawa, T., Demars, S., Gogos, J. A., Karayiorgou, M. et al. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc. Natl Acad. Sci. USA 100, 8993-8998 (2003).
6. Horiuchi, Y., Ishiguro, H., Koga, M., Inada, T., Iwata, N., Ozaki, N. et al. Support for association of the PPP3CC gene with schizophrenia. Mol. Psychiatry 12, 891-893 (2007).
7. Liu, Y. L., Fann, C. S., Liu, C. M., Chang, C. C., Yang, W. C., Hung, S. I. et al. More evidence supports the association of PPP3CC with schizophrenia. Mol. Psychiatry 12, 966-974 (2007).
8. Yamada, K., Gerber, D. J., Iwayama, Y., Ohnishi, T., Ohba, H., Toyota, T. et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl Acad. Sci. USA 104, 2815-2820 (2007).
9. Ruano, D., Aulchenko, Y. S., Macedo, A., Soares, M. J., Valente, J., Azevedo, M. H. et al. Association of the gene encoding neurogranin with schizophrenia in males. J. Psychiatr. Res. 42, 125-133 (2008).
10. Fallin, M. D., Lasseter, V. K., Avramopoulos, D., Nicodemus, K. K., Wolyniec, P. S., McGrath, J. A. et al. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am. J. Hum. Genet. 77, 918-936 (2005).
11. Kinoshita, Y., Suzuki, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Inada, T. et al. No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia. J. Neural. Transm. 112, 1255-1262 (2005).
12. Xi, Z., Yu, L., Shi, Y., Zhang, J., Zheng, Y., He, G. et al. No association between PPP3CC and schizophrenia in the Chinese population. Schizophr. Res. 90, 357-359 (2007).
13. Sanders, A. R., Duan, J., Levinson, D. F., Shi, J., He, D., Hou, C. et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am. J. Psychiatry 165, 497-506 (2008).
14. Betcheva, E. T., Mushiroda, T., Takahashi, A., Kubo, M., Karachanak, S. K., Zaharieva, I. T. et al. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957 T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J. Hum. Genet. 54, 98-107 (2009).
15. Badner, J. A. & Gershon, E. S. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol. Psychiatry 7, 405-411 (2002).
16. Lewis, C. M., Levinson, D. F., Wise, L. H., DeLisi, L. E., Straub, R. E., Hovatta, I. et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am. J. Hum. Genet. 73, 34-48 (2003).
17. Watanabe, Y., Muratake, T., Kaneko, N., Nunokawa, A. & Someya, T. No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Schizophr. Res. 84, 29-35 (2006).
18. Barrett, J. C., Fry, B., Maller, J. & Daly, M. J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
19. Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225-2229 (2002).
20. Purcell, S., Cherny, S. S. & Sham, P. C. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19, 149-150 (2003).