Simultaneous determination of β2-agonists in human urine by fast-gas chromatography/mass spectrometry: Method validation and clinical application

Biomedical Chromatography

Volumn 24, Issue 4, 2010, Pages 358-366

  Di Corcia, Daniele ^a   Morra, Veronica ^a   Pazzi, Marco ^b   Vincenti, Marco ^a,b  

^a Regione Gonzole 10 1   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Asthma; Fast GC MS; Urine screening; Validation

Indexed keywords

BODY FLUIDS; DRUG PRODUCTS; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SOLVENT EXTRACTION;

ASTHMA; FAST GAS CHROMATOGRAPHY; FAST GC/MS; HUMAN URINE; METHOD VALIDATIONS; SAMPLE PROCESSING; SHORT COLUMN; SIMULTANEOUS DETERMINATIONS; URINE SCREENING; VALIDATION;

SIGNAL TO NOISE RATIO;

BAMBUTEROL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CIMBUTEROL; FENOTEROL; FORMOTEROL; ISOPRENALINE; MAPENTEROL; ORCIPRENALINE; PROCATEROL; RACTOPAMINE; RITODRINE; SALBUTAMOL; SALMETEROL; TERBUTALINE; TRIMETHYLSILYL DERIVATIVE; TULOBUTEROL; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE;

ARTICLE; CASE REPORT; CONTROLLED STUDY; HUMAN; HYDROLYSIS; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; ASTHMA; CHEMISTRY; DRUG POTENTIATION; METHODOLOGY; REGRESSION ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; URINE;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ASTHMA; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LEAST-SQUARES ANALYSIS; RECEPTORS, ADRENERGIC, BETA-2; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 77950288893     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1300     Document Type: Article

References (21)

1. Amendola L, Colamonici C, Rossi F and Botrè F. Determination of clenbuterol in human urine by GC-MS-MS-MS: confirmation analysis in antidoping control. Journal of Chromatography B 2002; 773: 7-16.
2. Brunelli C, Bicchi C, Di Stilo A, Salomone A and Vincenti M. High-speed gas chromatography in doping control: Fast-GC and fast-GC/MS determination of β-adrenoceptor ligands and diuretics. Journal of Separation Science 2006; 29: 2765-2771.
3. 2-agonists by gas chromatographic/mass spectrometric analysis. Journal of Mass Spectrometry 2000; 35: 1285-1294.
4. Damasceno L, Ventura R, Cardoso J and Segura J. Diagnostic evidence for the presence of β-agonists using two consecutive derivatization procedures and gas chromatography-mass spectrometric analysis. Journal of Chromatography B 2002; 780: 61-71.
5. 2-Agonist extraction procedures for chromatographic analysis. Journal of Chromatography A 2000; 880: 69-83.
6. García I, Sarabia L, Ortiz MC and Aldama JM. Three-way models and detection capability of a gas chromatography-mass spectrometry method for the determination of clenbuterol in several biological matrices: the 2002/657/EC European Decision. Analytica Chimica Acta 2004; 515: 55-63.
7. Gunnar T, Ariniemi K and Lillsunde P. Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry. Journal of Mass Spectrometry 2005; 40: 739-753.
8. Henze MK, Opfermann G, Spahn-Langguth H and Schänzer W. Screening of β-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives. Journal of Chromatography B: Biomedical Sciences and Applications 2001; 751: 93-105.
9. Hubert Ph, Chiap P, Crommen J, Boulanger B, Chapuzet E, Mercier N, Bervoas-Martin S, Chevalier P, Grandjean D, Lagorce P, Lallier M, Laparra MC, Laurentie M and Nivet JC. The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory. Analytica Chimica Acta 1999; 391: 135-148.
10. Jiménez C, Ventura R and Segura J. Validation of qualitative chromatographic methods: strategy in antidoping control laboratories. Journal of Chromatography B 2002; 767: 341-351.
11. Kolmonen M, Leinonen A, Pelander A and Ojanpera I. A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry. Analytica Chimica Acta 2007; 585: 94-102.
12. Marcos J, Pascual JA, de la Torre X and Segura J. Fast screening of anabolic steroids and other banned doping substances in human urine by gas chromatography/tandem mass spectrometry. Journal of Mass Spectrometry 2002; 37: 1059-1073.
13. Maštovská K and Lehotay SJ. Practical approaches to fast gas chromatography-mass spectrometry. Journal of Chromatography A 2003; 1000: 153-180.
14. Matisová, E and Dömötörová M. Fast gas chromatography and its use in trace analysis. Journal of Chromatography A 2003; 1000: 199-221.
15. Mazzarino M, Orengia M and Botrè F. Application of fast gas chromatography/ mass spectrometry for the rapid screening of synthetic anabolic steroids and other drugs in anti-doping analysis. Rapid Communications in Mass Spectrometry 2007; 21: 4117-4124.
16. Morra V, Davit P, Capra P, Vincenti M, Di Stilo A and Botrè F. Fast gas chromatographic/ mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis. Journal of Chromatography A 2006; 1135: 219-229.
17. 2-agonists by hyphenated chromatographic and mass spectrometric techniques. Journal of Chromatography B: Biomedical Sciences and Applications 1996; 687: 27-42.
18. 2-Adrenergic agonist residues: simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography-mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 1998; 716: 366-370.
19. 2-agonists in human or equine urine. Journal of Mass Spectrometry 2003; 38: 1197-1206.
20. Ventura R, González G, Smeyers MT, de la Torre R and Segura J. Screening Procedure for β-Adrenergic Drugs in Sports Drug Testing by Immunological Methods. Journal of Analytical Toxicology 1998; 22: 127-134.
21. 2-agonists in urine by gas chromatography-mass spectrometry for application in doping control. Analytica Chimica Acta 2000; 418: 79-92.